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HINFP histone H4 transcription factor [ Homo sapiens (human) ]

Gene ID: 25988, updated on 5-Mar-2024

Summary

Official Symbol
HINFPprovided by HGNC
Official Full Name
histone H4 transcription factorprovided by HGNC
Primary source
HGNC:HGNC:17850
See related
Ensembl:ENSG00000172273 MIM:607099; AllianceGenome:HGNC:17850
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIZF; HiNF-P; ZNF743
Summary
This gene encodes a transcription factor that interacts with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in testis (RPKM 6.2), lymph node (RPKM 4.3) and 25 other tissues See more
Orthologs
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Genomic context

See HINFP in Genome Data Viewer
Location:
11q23.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (119121580..119136059)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (119141956..119156439)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118992290..119006769)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118965105-118965668 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118965669-118966232 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118966233-118966796 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:118966797-118967358 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:118972216-118973415 Neighboring gene dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 Neighboring gene H2A.X variant histone Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3969 Neighboring gene C2CD2 like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119027357-119027857 Neighboring gene ATP binding cassette subfamily G member 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119029281-119029780 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119039524-119040229 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119040230-119040934 Neighboring gene NLR family member X1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp434F162

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell cycle G1/S phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in in utero embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H4 transcription factor
Names
MBD2 (methyl-CpG-binding protein)-interacting zinc finger protein
MBD2-interacting zinc finger 1
MBD2-interacting zinc finger protein
histone H4 gene-specific protein HiNF-P
histone nuclear factor P
methyl-CpG-binding protein 2-interacting zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243259.2NP_001230188.1  histone H4 transcription factor isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AP002956, AP003391
    Consensus CDS
    CCDS58188.1
    UniProtKB/Swiss-Prot
    Q9BQA5
    Related
    ENSP00000436815.1, ENST00000527410.3
    Conserved Domains (2) summary
    COG5236
    Location:171303
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001351957.2NP_001338886.1  histone H4 transcription factor isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (3).
    Source sequence(s)
    AP002956, AP003391
    Conserved Domains (2) summary
    COG5236
    Location:194326
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:309329
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001351958.2NP_001338887.1  histone H4 transcription factor isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 2, 6, and 7, encodes isoform 1.
    Source sequence(s)
    AP002956, AP003391
    Consensus CDS
    CCDS8414.1
    UniProtKB/Swiss-Prot
    B3KPH6, B4DWB4, E9PQF4, Q96E65, Q9BQA5, Q9Y4M7
    Conserved Domains (2) summary
    COG5236
    Location:171303
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001351959.2NP_001338888.1  histone H4 transcription factor isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 2, 5, and 7, encodes isoform 1.
    Source sequence(s)
    AP002956, AP003391
    Consensus CDS
    CCDS8414.1
    UniProtKB/Swiss-Prot
    B3KPH6, B4DWB4, E9PQF4, Q96E65, Q9BQA5, Q9Y4M7
    Conserved Domains (2) summary
    COG5236
    Location:171303
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001351960.2NP_001338889.1  histone H4 transcription factor isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 1, 2, 5, and 6, encodes isoform 1.
    Source sequence(s)
    AP002956, AP003391
    Consensus CDS
    CCDS8414.1
    UniProtKB/Swiss-Prot
    B3KPH6, B4DWB4, E9PQF4, Q96E65, Q9BQA5, Q9Y4M7
    Conserved Domains (2) summary
    COG5236
    Location:171303
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001351961.2NP_001338890.1  histone H4 transcription factor isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variant 9, encodes isoform 4.
    Source sequence(s)
    AP002956, AP003391
    Conserved Domains (2) summary
    COG5236
    Location:171303
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. NM_001351962.2NP_001338891.1  histone H4 transcription factor isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variant 8, encodes isoform 4.
    Source sequence(s)
    AP002956, AP003391
    Conserved Domains (2) summary
    COG5236
    Location:171303
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. NM_001351963.2NP_001338892.1  histone H4 transcription factor isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variant 11, encodes isoform 5.
    Source sequence(s)
    AP002956, AP003391
    Conserved Domains (2) summary
    COG5236
    Location:2297
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:80100
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. NM_001351964.2NP_001338893.1  histone H4 transcription factor isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variant 10, encodes isoform 5.
    Source sequence(s)
    AP002956, AP003391
    Conserved Domains (2) summary
    COG5236
    Location:2297
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:80100
    ZF_C2H2; C2H2 Zn finger [structural motif]
  10. NM_001351965.2NP_001338894.1  histone H4 transcription factor isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 13, 14, 15, 16, and 17, encodes isoform 6.
    Source sequence(s)
    AP002956, AP003391
    Conserved Domains (2) summary
    sd00017
    Location:3959
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1031
    ZF_C2H2; C2H2 Zn finger [structural motif]
  11. NM_001351966.2NP_001338895.1  histone H4 transcription factor isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 12, 14, 15, 16, and 17, encodes isoform 6.
    Source sequence(s)
    AP002956, AP003391
    Conserved Domains (2) summary
    sd00017
    Location:3959
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1031
    ZF_C2H2; C2H2 Zn finger [structural motif]
  12. NM_001351969.2NP_001338898.1  histone H4 transcription factor isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 12, 13, 15, 16, and 17, encodes isoform 6.
    Source sequence(s)
    AP002956, AP003391
    Conserved Domains (2) summary
    sd00017
    Location:3959
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1031
    ZF_C2H2; C2H2 Zn finger [structural motif]
  13. NM_001351971.2NP_001338900.1  histone H4 transcription factor isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 12, 13, 14, 16, and 17, encodes isoform 6.
    Source sequence(s)
    AP002956, AP003391
    Conserved Domains (2) summary
    sd00017
    Location:3959
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1031
    ZF_C2H2; C2H2 Zn finger [structural motif]
  14. NM_001351972.2NP_001338901.1  histone H4 transcription factor isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 12, 13, 14, 15, and 17, encodes isoform 6.
    Source sequence(s)
    AP002956, AP003391
    Conserved Domains (2) summary
    sd00017
    Location:3959
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1031
    ZF_C2H2; C2H2 Zn finger [structural motif]
  15. NM_001351974.2NP_001338903.1  histone H4 transcription factor isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 12, 13, 14, 15, and 16, encodes isoform 6.
    Source sequence(s)
    AP002956, AP003391
    Conserved Domains (2) summary
    sd00017
    Location:3959
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1031
    ZF_C2H2; C2H2 Zn finger [structural motif]
  16. NM_015517.5NP_056332.2  histone H4 transcription factor isoform 1

    See identical proteins and their annotated locations for NP_056332.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variants 2, 5, 6, and 7, encodes isoform 1.
    Source sequence(s)
    AP002956, AP003391
    Consensus CDS
    CCDS8414.1
    UniProtKB/Swiss-Prot
    B3KPH6, B4DWB4, E9PQF4, Q96E65, Q9BQA5, Q9Y4M7
    Conserved Domains (2) summary
    COG5236
    Location:171303
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
  17. NM_198971.3NP_945322.1  histone H4 transcription factor isoform 1

    See identical proteins and their annotated locations for NP_945322.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 1, 5, 6, and 7, encodes isoform 1.
    Source sequence(s)
    AP002956, AP003391
    Consensus CDS
    CCDS8414.1
    UniProtKB/Swiss-Prot
    B3KPH6, B4DWB4, E9PQF4, Q96E65, Q9BQA5, Q9Y4M7
    Related
    ENSP00000318085.3, ENST00000350777.7
    Conserved Domains (2) summary
    COG5236
    Location:171303
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    119121580..119136059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542744.3XP_011541046.1  histone H4 transcription factor isoform X1

    Conserved Domains (2) summary
    COG5236
    Location:185317
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:300320
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_017017499.2XP_016872988.1  histone H4 transcription factor isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    119141956..119156439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368356.1XP_054224331.1  histone H4 transcription factor isoform X1

  2. XM_054368357.1XP_054224332.1  histone H4 transcription factor isoform X2