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KANK2 KN motif and ankyrin repeat domains 2 [ Homo sapiens (human) ]

Gene ID: 25959, updated on 7-Apr-2024

Summary

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Official Symbol
KANK2provided by HGNC
Official Full Name
KN motif and ankyrin repeat domains 2provided by HGNC
Primary source
HGNC:HGNC:29300
See related
Ensembl:ENSG00000197256 MIM:614610; AllianceGenome:HGNC:29300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIP; MXRA3; PPKWH; NPHS16; ANKRD25
Summary
This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in endometrium (RPKM 77.8), ovary (RPKM 51.9) and 21 other tissues See more
Orthologs
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Genomic context

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Location:
19p13.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11164270..11197865, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11291296..11324866, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11274946..11308541, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor Neighboring gene microRNA 6886 Neighboring gene VISTA enhancer hs1754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10101 Neighboring gene SPC24 component of NDC80 kinetochore complex Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11276922-11277422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11300095-11300596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11300597-11301096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10103 Neighboring gene DOCK6 antisense RNA 1 Neighboring gene dedicator of cytokinesis 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11347000-11347810 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11347811-11348621 Neighboring gene angiopoietin like 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Steroid receptor co-activator interacting protein (SIP) mediates EGF-stimulated expression of the prostaglandin synthase COX2 and prostaglandin release in human myometrium. Hudson CA, et al. Mol Hum Reprod, 2016 Jul. PMID 27161844
  2. A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions. Rafiq NBM, et al. Nat Mater, 2019 Jun. PMID 31114072
  3. Mutation in KANK2, encoding a sequestering protein for steroid receptor coactivators, causes keratoderma and woolly hair. Ramot Y, et al. J Med Genet, 2014 Jun. PMID 24671081
  4. Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins. Guo Q, et al. J Biol Chem, 2018 Jan 12. PMID 29183992, Free PMC Article
  5. Association of liprin β-1 with kank proteins in melanoma. Luo M, et al. Exp Dermatol, 2016 Apr. PMID 26739330, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line.
    Title: Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line.
  2. KANK2 protein is required for targeting microtubules to focal adhesions.
    Title: A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions.
  3. liprin beta-1 is associated with expression of kank 1 and 2 proteins in melanoma
    Title: Association of liprin β-1 with kank proteins in melanoma.
  4. identified recessive mutations in kidney ankyrin repeat-containing protein 1 (KANK1), KANK2, and KANK4 in individuals with nephrotic syndrome.
    Title: KANK deficiency leads to podocyte dysfunction and nephrotic syndrome.
  5. Using whole-exome sequencing, authors identified a homozygous missense c.2009C>T mutation in KANK2
    Title: Mutation in KANK2, encoding a sequestering protein for steroid receptor coactivators, causes keratoderma and woolly hair.
  6. SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm.
    Title: SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Nephrotic syndrome 16
MedGen: C4540453 OMIM: 617783 GeneReviews: Not available
Compare labs
Wooly hair-palmoplantar keratoderma syndrome
MedGen: C4015202 OMIM: 616099 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20004, KIAA1518, MGC119707, DKFZp434N161

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in kidney epithelium development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of intracellular estrogen receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of intracellular estrogen receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of programmed cell death IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of vitamin D receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of vitamin D receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in podocyte cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
KN motif and ankyrin repeat domain-containing protein 2
Names
SRC-interacting protein
SRC1-interacting protein
ankyrin repeat domain-containing protein 25
kidney ankyrin repeat-containing protein 2
matrix-remodeling-associated protein 3
steroid receptor coactivator interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051186.2 RefSeqGene

    Range
    5320..38595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001136191.3 → NP_001129663.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001129663.1

    Status: REVIEWED

    Source sequence(s)
    AC009000, AC011485
    Consensus CDS
    CCDS12255.1
    UniProtKB/Swiss-Prot
    B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
    Related
    ENSP00000465650.1, ENST00000586659.6
    Conserved Domains (4) summary
    COG0666
    Location:651 → 806
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:739 → 769
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 69
    KN_motif; KN motif
    pfam12796
    Location:743 → 828
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_001329451.2 → NP_001316380.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009000, AC011485
    Consensus CDS
    CCDS12255.1
    UniProtKB/Swiss-Prot
    B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
    Conserved Domains (4) summary
    COG0666
    Location:651 → 806
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:739 → 769
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 69
    KN_motif; KN motif
    pfam12796
    Location:743 → 828
    Ank_2; Ankyrin repeats (3 copies)

  3. NM_001379548.1 → NP_001366477.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC009000, AC011485
    Consensus CDS
    CCDS54219.1
    Conserved Domains (5) summary
    COG0666
    Location:659 → 814
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    PRK13108
    Location:450 → 593
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    sd00045
    Location:747 → 777
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 69
    KN_motif; KN motif
    pfam12796
    Location:751 → 836
    Ank_2; Ankyrin repeats (3 copies)

  4. NM_001379549.1 → NP_001366478.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC009000, AC011485
    Consensus CDS
    CCDS54219.1
    Related
    ENSP00000468002.1, ENST00000589359.5
    Conserved Domains (5) summary
    COG0666
    Location:659 → 814
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    PRK13108
    Location:450 → 593
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    sd00045
    Location:747 → 777
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 69
    KN_motif; KN motif
    pfam12796
    Location:751 → 836
    Ank_2; Ankyrin repeats (3 copies)

  5. NM_001379550.1 → NP_001366479.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC009000, AC011485
    Consensus CDS
    CCDS54219.1
    Conserved Domains (5) summary
    COG0666
    Location:659 → 814
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    PRK13108
    Location:450 → 593
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    sd00045
    Location:747 → 777
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 69
    KN_motif; KN motif
    pfam12796
    Location:751 → 836
    Ank_2; Ankyrin repeats (3 copies)

  6. NM_001379551.1 → NP_001366480.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC009000, AC011485
    Consensus CDS
    CCDS54219.1
    Conserved Domains (5) summary
    COG0666
    Location:659 → 814
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    PRK13108
    Location:450 → 593
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    sd00045
    Location:747 → 777
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 69
    KN_motif; KN motif
    pfam12796
    Location:751 → 836
    Ank_2; Ankyrin repeats (3 copies)

  7. NM_001379552.1 → NP_001366481.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC009000, AC011485
    Consensus CDS
    CCDS54219.1
    Conserved Domains (5) summary
    COG0666
    Location:659 → 814
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    PRK13108
    Location:450 → 593
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    sd00045
    Location:747 → 777
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 69
    KN_motif; KN motif
    pfam12796
    Location:751 → 836
    Ank_2; Ankyrin repeats (3 copies)

  8. NM_001379553.1 → NP_001366482.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC009000, AC011485
    Consensus CDS
    CCDS54219.1
    Conserved Domains (5) summary
    COG0666
    Location:659 → 814
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    PRK13108
    Location:450 → 593
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    sd00045
    Location:747 → 777
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 69
    KN_motif; KN motif
    pfam12796
    Location:751 → 836
    Ank_2; Ankyrin repeats (3 copies)

  9. NM_001379554.1 → NP_001366483.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC009000, AC011485
    Consensus CDS
    CCDS54219.1
    Conserved Domains (5) summary
    COG0666
    Location:659 → 814
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    PRK13108
    Location:450 → 593
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    sd00045
    Location:747 → 777
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 69
    KN_motif; KN motif
    pfam12796
    Location:751 → 836
    Ank_2; Ankyrin repeats (3 copies)

  10. NM_001379555.1 → NP_001366484.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009000, AC011485
    Consensus CDS
    CCDS12255.1
    UniProtKB/Swiss-Prot
    B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
    Conserved Domains (4) summary
    COG0666
    Location:651 → 806
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:739 → 769
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 69
    KN_motif; KN motif
    pfam12796
    Location:743 → 828
    Ank_2; Ankyrin repeats (3 copies)

  11. NM_001379556.1 → NP_001366485.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009000, AC011485
    Consensus CDS
    CCDS12255.1
    UniProtKB/Swiss-Prot
    B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
    Conserved Domains (4) summary
    COG0666
    Location:651 → 806
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:739 → 769
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 69
    KN_motif; KN motif
    pfam12796
    Location:743 → 828
    Ank_2; Ankyrin repeats (3 copies)

  12. NM_001379557.1 → NP_001366486.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009000, AC011485
    Consensus CDS
    CCDS12255.1
    UniProtKB/Swiss-Prot
    B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
    Conserved Domains (4) summary
    COG0666
    Location:651 → 806
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:739 → 769
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 69
    KN_motif; KN motif
    pfam12796
    Location:743 → 828
    Ank_2; Ankyrin repeats (3 copies)

  13. NM_001379558.1 → NP_001366487.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009000, AC011485
    Consensus CDS
    CCDS12255.1
    UniProtKB/Swiss-Prot
    B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
    Conserved Domains (4) summary
    COG0666
    Location:651 → 806
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:739 → 769
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 69
    KN_motif; KN motif
    pfam12796
    Location:743 → 828
    Ank_2; Ankyrin repeats (3 copies)

  14. NM_001379559.1 → NP_001366488.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009000, AC011485
    Consensus CDS
    CCDS12255.1
    UniProtKB/Swiss-Prot
    B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
    Conserved Domains (4) summary
    COG0666
    Location:651 → 806
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:739 → 769
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 69
    KN_motif; KN motif
    pfam12796
    Location:743 → 828
    Ank_2; Ankyrin repeats (3 copies)

  15. NM_001379560.1 → NP_001366489.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009000, AC011485
    Consensus CDS
    CCDS12255.1
    UniProtKB/Swiss-Prot
    B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
    Conserved Domains (4) summary
    COG0666
    Location:651 → 806
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:739 → 769
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 69
    KN_motif; KN motif
    pfam12796
    Location:743 → 828
    Ank_2; Ankyrin repeats (3 copies)

  16. NM_001379561.1 → NP_001366490.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009000, AC011485
    Consensus CDS
    CCDS12255.1
    UniProtKB/Swiss-Prot
    B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
    Conserved Domains (4) summary
    COG0666
    Location:651 → 806
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:739 → 769
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 69
    KN_motif; KN motif
    pfam12796
    Location:743 → 828
    Ank_2; Ankyrin repeats (3 copies)

  17. NM_001379562.1 → NP_001366491.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009000, AC011485
    Consensus CDS
    CCDS12255.1
    UniProtKB/Swiss-Prot
    B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
    Conserved Domains (4) summary
    COG0666
    Location:651 → 806
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:739 → 769
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 69
    KN_motif; KN motif
    pfam12796
    Location:743 → 828
    Ank_2; Ankyrin repeats (3 copies)

  18. NM_001379563.1 → NP_001366492.1  KN motif and ankyrin repeat domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009000, AC011485
    Consensus CDS
    CCDS12255.1
    UniProtKB/Swiss-Prot
    B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
    Conserved Domains (4) summary
    COG0666
    Location:651 → 806
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:739 → 769
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 69
    KN_motif; KN motif
    pfam12796
    Location:743 → 828
    Ank_2; Ankyrin repeats (3 copies)

  19. NM_015493.7 → NP_056308.3  KN motif and ankyrin repeat domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_056308.3

    Status: REVIEWED

    Source sequence(s)
    AC009000, AC011485
    Consensus CDS
    CCDS54219.1
    UniProtKB/Swiss-Prot
    Q63ZY3
    Conserved Domains (5) summary
    COG0666
    Location:659 → 814
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    PRK13108
    Location:450 → 593
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    sd00045
    Location:747 → 777
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:31 → 69
    KN_motif; KN motif
    pfam12796
    Location:751 → 836
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    11164270..11197865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438576.1 → XP_047294532.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210

  2. XM_047438575.1 → XP_047294531.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210

  3. XM_047438572.1 → XP_047294528.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210

  4. XM_047438569.1 → XP_047294525.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X1

  5. XM_047438573.1 → XP_047294529.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210
    Related
    ENSP00000467029.1, ENST00000589894.1

  6. XM_047438574.1 → XP_047294530.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210

  7. XM_047438571.1 → XP_047294527.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X1

  8. XM_047438577.1 → XP_047294533.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    B0I1P4, Q3KQZ3, Q63ZY3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210

  9. XM_047438570.1 → XP_047294526.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    11291296..11324866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63ZY3.1 GenPept UniProtKB/Swiss-Prot:Q63ZY3

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