pad-2 GDP-fucose protein O-fucosyltransferase 2 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: pad-2
Official Full Name: GDP-fucose protein O-fucosyltransferase 2
Primary source: WormBase:WBGene00010757
Locus tag: CELE_K10G9.3
See related: AllianceGenome:WB:WBGene00010757
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables peptide-O-fucosyltransferase activity. Involved in protein O-linked fucosylation. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including excretory cell; hermaphrodite gonad; intestine; nervous system; and rectal gland cell. Used to study Down syndrome. Orthologous to human POFUT2 (protein O-fucosyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

pad-2 is required for normal development
Title: The Caenorhabditis elegans ortholog of C21orf80, a potential new protein O-fucosyltransferase, is required for normal development.

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Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables peptide-O-fucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide-O-fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide-O-fucosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables peptide-O-fucosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein O-linked fucosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein O-linked fucosylation	IEA Inferred from Electronic Annotation more info
involved_in protein O-linked fucosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in cellular_component	ND No biological Data available more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

NP_001255069.1

NP_001255070.1

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The following sections contain reference sequences that belong to a specific genome build. Explain