Npb neuropeptide B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Npbprovided by RGD
Official Full Name: neuropeptide Bprovided by RGD
Primary source: RGD:708513
See related: EnsemblRapid:ENSRNOG00000076694 AllianceGenome:RGD:708513
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables G protein-coupled receptor binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and feeding behavior. Predicted to be located in extracellular region. Orthologous to human NPB (neuropeptide B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 7.3), Spleen (RPKM 6.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (106382307..106385566)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (105883992..105887689)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (109786222..109786656)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of NPB, NPW and Their Receptor in the Rat Heart.
Title: Identification of NPB, NPW and Their Receptor in the Rat Heart.
The Neuropeptide B can affect glucose and lipid homeostasis, and food intake in rats.
Title: Neuropeptide B and W regulate leptin and resistin secretion, and stimulate lipolysis in isolated rat adipocytes.
RT-PCR technique revealed the presence of NPB mRNA, NPW mRNA, and NPBWR1 mRNA, but not similar to NPBWR2 mRNA in ROB cells.
Title: Neuropeptide B (NPB) and neuropeptide W (NPW) system in cultured rat calvarial osteoblast-like (ROB) cells: NPW and NPB inhibit proliferative activity of ROB cells.
NPB-immunoreactivity was enriched in many regions within the hypothalamus which also contained high levels of GPR7 mRNA.
Title: Immunofluorescent identification of neuropeptide B-containing nerve fibers and terminals in the rat hypothalamus.
demonstrates the expression patterns of GPR7, NPB, and NPW precursor messenger ribonucleic acid (mRNA) in the rat brain by using in situ hybridization and in situ binding experiments
Title: A study of the rat neuropeptide B/neuropeptide W system using in situ techniques.
neuropeptide B, a neuropeptide modified with bromine is an endogenous ligand for GPR7.
Title: Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuropeptide B

Names: preproneuropeptide B; preproprotein L7; rPPL7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.