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HSPA12A heat shock protein family A (Hsp70) member 12A [ Homo sapiens (human) ]

Gene ID: 259217, updated on 7-Apr-2024

Summary

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Official Symbol
HSPA12Aprovided by HGNC
Official Full Name
heat shock protein family A (Hsp70) member 12Aprovided by HGNC
Primary source
HGNC:HGNC:19022
See related
Ensembl:ENSG00000165868 MIM:610701; AllianceGenome:HGNC:19022
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ATP binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 23.0), fat (RPKM 11.2) and 16 other tissues See more
Orthologs
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Genomic context

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See HSPA12A in Genome Data Viewer
Location:
10q25.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (116671192..116850747, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (117565518..117745047, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (118430703..118609233, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:118393650-118394849 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118405699-118406228 Neighboring gene pancreatic lipase related protein 2 (gene/pseudogene) Neighboring gene Sharpr-MPRA regulatory region 10762 Neighboring gene HSPA12A antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118441833-118442334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118442335-118442834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118450610-118451348 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118453631-118454602 Neighboring gene sperm microtubule inner protein 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118501942-118502646 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118502647-118503350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118526330-118526895 Neighboring gene uncharacterized LOC105378498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118534387-118534886 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:118538206-118539405 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:118544309-118544475 Neighboring gene ribosomal protein L5 pseudogene 27 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:118595447-118596082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4095 Neighboring gene microRNA 9851 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:118665638-118666837 Neighboring gene enolase 4 Neighboring gene shootin 1 Neighboring gene Sharpr-MPRA regulatory region 1976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2857 Neighboring gene VISTA enhancer hs841 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118885664-118886164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118890627-118891154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118891155-118891681 Neighboring gene ventral anterior homeobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. HSPA12A was identified as a key driver in colorectal cancer GWAS loci 10q26.12 and modulated by an enhancer-promoter interaction. Lu Z, et al. Arch Toxicol, 2023 Jul. PMID 37245169
  2. Heat shock protein A12A activates migration of hepatocellular carcinoma cells in a monocarboxylate transporter 4-dependent manner. Min X, et al. Cell Stress Chaperones, 2022 Jan. PMID 35050463, Free PMC Article
  3. Heat-Shock protein A12A is a novel PCNA-binding protein and promotes hepatocellular carcinoma growth. Cheng H, et al. FEBS J, 2020 Dec. PMID 32128976
  4. Heat shock protein 12A shows reduced expression in the prefrontal cortex of subjects with schizophrenia. Pongrac JL, et al. Biol Psychiatry, 2004 Dec 15. PMID 15601604
  5. Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer. Pan YJ, et al. Clin Transl Med, 2022 Nov. PMID 36394206, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Heat-shock protein A12A attenuates oxygen-glucose deprivation/reoxygenation-induced human brain microvascular endothelial cell dysfunction via PGC-1alpha/SIRT3 pathway.
    Title: Heat-shock protein A12A attenuates oxygen-glucose deprivation/reoxygenation-induced human brain microvascular endothelial cell dysfunction via PGC-1α/SIRT3 pathway.
  2. HSPA12A was identified as a key driver in colorectal cancer GWAS loci 10q26.12 and modulated by an enhancer-promoter interaction.
    Title: HSPA12A was identified as a key driver in colorectal cancer GWAS loci 10q26.12 and modulated by an enhancer-promoter interaction.
  3. Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.
    Title: Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.
  4. Heat shock protein A12A activates migration of hepatocellular carcinoma cells in a monocarboxylate transporter 4-dependent manner.
    Title: Heat shock protein A12A activates migration of hepatocellular carcinoma cells in a monocarboxylate transporter 4-dependent manner.
  5. Heat-Shock protein A12A is a novel PCNA-binding protein and promotes hepatocellular carcinoma growth.
    Title: Heat-Shock protein A12A is a novel PCNA-binding protein and promotes hepatocellular carcinoma growth.
  6. HSPA12A unstabilizes CD147 to inhibit lactate export and migration in human renal cell carcinoma.
    Title: HSPA12A unstabilizes CD147 to inhibit lactate export and migration in human renal cell carcinoma.
  7. The genotype "A/G" of rs1665650 in HSPA12A gene was associated with a decreased risk of gastric cancer.
    Title: Polymorphisms of PRLHR and HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population.
  8. High BCLC staging scores, advanced cirrhosis and the overexpression of HSPA12A and HSP90B1 might be associated with poor survival from HCC, whereas high levels of HSPA4, HSPA5 and HSPA6 might be associated with earlier recurrence of HCC
    Title: Upregulation of heat shock proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in tumour tissues is associated with poor outcomes from HBV-related early-stage hepatocellular carcinoma.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.
  10. We found that HSPA12A is expressed in the human brain and shows a neuron- and region-specific transcript distribution, with strongest expression in the frontal and occipital cortical regions. HSPA12A Mrna was significantly reduced in schizophrenia.
    Title: Heat shock protein 12A shows reduced expression in the prefrontal cortex of subjects with schizophrenia.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes.
EBI GWAS Catalog
Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer.
EBI GWAS Catalog
Genome-wide association study of smoking behaviours in patients with COPD.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13874, KIAA0417

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heat shock 70 kDa protein 12A
Names
heat shock 70kD protein 12A
heat shock 70kDa protein 12A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330164.2 → NP_001317093.1  heat shock 70 kDa protein 12A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC016825, AC023283, AK294884, AL120441, BC041412, BM471679, DA416906, DC335324
    Consensus CDS
    CCDS81511.1
    UniProtKB/TrEMBL
    A0A1B0GTF3, A0A6I8PIW1
    Related
    ENSP00000489674.1, ENST00000635765.1
    Conserved Domains (1) summary
    cd11735
    Location:74 → 540
    HSPA12A_like_NBD; Nucleotide-binding domain of HSPA12A and similar proteins

  2. NM_025015.3 → NP_079291.2  heat shock 70 kDa protein 12A isoform 2

    See identical proteins and their annotated locations for NP_079291.2

    Status: VALIDATED

    Source sequence(s)
    AB007877, BU738372
    Consensus CDS
    CCDS41569.1
    UniProtKB/Swiss-Prot
    O43301
    UniProtKB/TrEMBL
    A0A6I8PIW1
    Related
    ENSP00000358211.3, ENST00000369209.8
    Conserved Domains (1) summary
    cd11735
    Location:57 → 523
    HSPA12A_like_NBD; Nucleotide-binding domain of HSPA12A and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    116671192..116850747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269673.6 → XP_005269730.1  heat shock 70 kDa protein 12A isoform X1

    See identical proteins and their annotated locations for XP_005269730.1

    UniProtKB/TrEMBL
    A0A6I8PIW1, A0A6I8PLB1
    Related
    ENSP00000501472.1, ENST00000674197.1
    Conserved Domains (1) summary
    cd11735
    Location:73 → 539
    HSPA12A_like_NBD; Nucleotide-binding domain of HSPA12A and similar proteins

  2. XM_011539579.3 → XP_011537881.1  heat shock 70 kDa protein 12A isoform X1

    See identical proteins and their annotated locations for XP_011537881.1

    UniProtKB/TrEMBL
    A0A6I8PIW1, A0A6I8PLB1
    Conserved Domains (1) summary
    cd11735
    Location:73 → 539
    HSPA12A_like_NBD; Nucleotide-binding domain of HSPA12A and similar proteins

  3. XM_047424971.1 → XP_047280927.1  heat shock 70 kDa protein 12A isoform X2

    UniProtKB/TrEMBL
    A0A6I8PIT5
    Related
    ENSP00000501414.1, ENST00000674401.1

  4. XM_047424972.1 → XP_047280928.1  heat shock 70 kDa protein 12A isoform X3

    Related
    ENSP00000501346.1, ENST00000674344.1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791790.1 Reference GRCh38.p14 PATCHES

    Range
    82188..153562 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    117565518..117745047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365431.1 → XP_054221406.1  heat shock 70 kDa protein 12A isoform X1

    UniProtKB/TrEMBL
    A0A6I8PLB1

  2. XM_054365432.1 → XP_054221407.1  heat shock 70 kDa protein 12A isoform X1

    UniProtKB/TrEMBL
    A0A6I8PLB1

  3. XM_054365433.1 → XP_054221408.1  heat shock 70 kDa protein 12A isoform X2

    UniProtKB/TrEMBL
    A0A6I8PIT5

  4. XM_054365434.1 → XP_054221409.1  heat shock 70 kDa protein 12A isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43301.2 GenPept UniProtKB/Swiss-Prot:O43301

Gene LinkOut

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