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caska calcium/calmodulin-dependent serine protein kinase a [ Danio rerio (zebrafish) ]

Gene ID: 259195, updated on 14-Nov-2024

Summary

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Official Symbol
caskaprovided by ZNC
Official Full Name
calcium/calmodulin-dependent serine protein kinase aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020802-4
See related
Ensembl:ENSDARG00000059809 AllianceGenome:ZFIN:ZDB-GENE-020802-4
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cask; wu:fb70g06
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in protein localization and regulation of neurotransmitter secretion. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane and cell-cell junction. Is expressed in nervous system; notochord; optic vesicle; and yolk syncytial layer. Human ortholog(s) of this gene implicated in FG syndrome and syndromic X-linked intellectual disability Najm type. Orthologous to human CASK (calcium/calmodulin dependent serine protein kinase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See caska in Genome Data Viewer
Location:
chromosome: 9
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (33365307..33608967, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (33555139..33799816, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 3 X-linked a Neighboring gene si:dkey-216e24.9 Neighboring gene nyctalopin Neighboring gene G protein-coupled receptor 34b Neighboring gene uncharacterized LOC137496483 Neighboring gene monoamine oxidase Neighboring gene norrin cystine knot growth factor NDP

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Novel CASK mutations in cases with syndromic microcephaly. Cristofoli F, et al. Hum Mutat, 2018 Jul. PMID 29691940, Free PMC Article
  2. Progesterone alters global transcription profiles at environmental concentrations in brain and ovary of female zebrafish (Danio rerio). Zucchi S, et al. Environ Sci Technol, 2013. PMID 24083816
  3. Drosophila Varicose, a member of a new subgroup of basolateral MAGUKs, is required for septate junctions and tracheal morphogenesis. Wu VM, et al. Development, 2007 Mar. PMID 17267446, Free PMC Article
  4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peripheral plasma membrane protein CASK
NP_001410498.1
XP_017213110.1
XP_017213111.1
XP_017213113.1
XP_017213114.1
XP_017213115.1
XP_017213116.1
XP_017213118.1
XP_017213119.1
XP_017213120.1
XP_017213121.1
XP_017213122.1
XP_017213123.1
XP_017213124.1
XP_017213125.1
XP_017213126.1
XP_017213127.1
XP_017213128.1
XP_017213129.1
XP_017213130.1
XP_017213131.1
XP_017213132.1
XP_017213133.1
XP_068079380.1
XP_068079381.1
XP_068079382.1
XP_068079383.1
XP_068079384.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001423569.1 → NP_001410498.1  peripheral plasma membrane protein CASK

    Status: VALIDATED

    Source sequence(s)
    BX545856, CABZ01004692, CR752653
    UniProtKB/TrEMBL
    A0A8M9QJH6

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    33365307..33608967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017357643.3 → XP_017213132.1  peripheral plasma membrane protein CASK isoform X26

    UniProtKB/TrEMBL
    A0A8M6Z0U6, Q910A4

  2. XM_017357641.3 → XP_017213130.1  peripheral plasma membrane protein CASK isoform X24

    UniProtKB/TrEMBL
    A0A8M6Z064, B3DH78, F1QK58, Q910A4
    Related
    ENSDARP00000091622.5, ENSDART00000100849.5
    Conserved Domains (8) summary
    smart00569
    Location:342 → 395
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12035
    Location:610 → 671
    SH3_MPP1-like; Src Homology 3 domain of Membrane Protein, Palmitoylated 1 (or MAGUK p55 subfamily member 1)-like proteins
    smart00072
    Location:742 → 905
    GuKc; Guanylate kinase homologues
    smart00220
    Location:12 → 276
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:482 → 562
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd14094
    Location:8 → 307
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
    pfam00625
    Location:732 → 905
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:400 → 446
    L27; L27 domain

  3. XM_068223282.1 → XP_068079383.1  peripheral plasma membrane protein CASK isoform X18

  4. XM_017357644.3 → XP_017213133.1  peripheral plasma membrane protein CASK isoform X27

    UniProtKB/TrEMBL
    A0A8M6Z2H6, Q910A4

  5. XM_017357634.3 → XP_017213123.1  peripheral plasma membrane protein CASK isoform X14

    UniProtKB/TrEMBL
    A0A8M6Z2G8, Q910A4

  6. XM_017357626.3 → XP_017213115.1  peripheral plasma membrane protein CASK isoform X5

    UniProtKB/TrEMBL
    A0A8M6Z7Y8, Q910A4

  7. XM_017357642.3 → XP_017213131.1  peripheral plasma membrane protein CASK isoform X25

    UniProtKB/TrEMBL
    A0A8M6Z7Z6, Q910A4

  8. XM_017357640.3 → XP_017213129.1  peripheral plasma membrane protein CASK isoform X23

    UniProtKB/TrEMBL
    A0A8M6Z8D0, Q910A4

  9. XM_017357638.3 → XP_017213127.1  peripheral plasma membrane protein CASK isoform X21

    UniProtKB/TrEMBL
    A0A8M6Z0U1, Q910A4

  10. XM_017357636.3 → XP_017213125.1  peripheral plasma membrane protein CASK isoform X17

    UniProtKB/TrEMBL
    A0A8M6Z057, Q910A4

  11. XM_017357632.3 → XP_017213121.1  peripheral plasma membrane protein CASK isoform X11

    UniProtKB/TrEMBL
    A0A8M6Z7Z0, Q910A4

  12. XM_017357622.3 → XP_017213111.1  peripheral plasma membrane protein CASK isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z2G0, Q910A4

  13. XM_017357633.3 → XP_017213122.1  peripheral plasma membrane protein CASK isoform X13

    UniProtKB/TrEMBL
    A0A8M6Z0T7, Q910A4

  14. XM_017357625.3 → XP_017213114.1  peripheral plasma membrane protein CASK isoform X4

    UniProtKB/TrEMBL
    A0A8M6Z050, Q910A4

  15. XM_017357639.3 → XP_017213128.1  peripheral plasma membrane protein CASK isoform X22

    UniProtKB/TrEMBL
    A0A8M6Z2H1, Q910A4

  16. XM_068223283.1 → XP_068079384.1  peripheral plasma membrane protein CASK isoform X20

  17. XM_068223281.1 → XP_068079382.1  peripheral plasma membrane protein CASK isoform X16

  18. XM_017357631.3 → XP_017213120.1  peripheral plasma membrane protein CASK isoform X10

    UniProtKB/TrEMBL
    A0A8M6Z054, Q910A4

  19. XM_017357637.3 → XP_017213126.1  peripheral plasma membrane protein CASK isoform X19

    UniProtKB/TrEMBL
    A0A8M6Z7Z3, Q910A4

  20. XM_017357635.3 → XP_017213124.1  peripheral plasma membrane protein CASK isoform X15

    UniProtKB/TrEMBL
    A0A8M6Z8C8, Q910A4

  21. XM_068223280.1 → XP_068079381.1  peripheral plasma membrane protein CASK isoform X12

  22. XM_017357629.3 → XP_017213118.1  peripheral plasma membrane protein CASK isoform X8

    UniProtKB/TrEMBL
    A0A8M6Z2G4, Q910A4

  23. XM_017357630.3 → XP_017213119.1  peripheral plasma membrane protein CASK isoform X9

    UniProtKB/TrEMBL
    A0A8M6Z8C4, Q910A4

  24. XM_017357624.3 → XP_017213113.1  peripheral plasma membrane protein CASK isoform X3

    UniProtKB/TrEMBL
    A0A8M6Z8C0, Q910A4

  25. XM_017357627.3 → XP_017213116.1  peripheral plasma membrane protein CASK isoform X6

    UniProtKB/TrEMBL
    A0A8M6Z0T2, Q910A4

  26. XM_017357621.3 → XP_017213110.1  peripheral plasma membrane protein CASK isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z0S9, Q910A4

  27. XM_068223279.1 → XP_068079380.1  peripheral plasma membrane protein CASK isoform X7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152941.1: Suppressed sequence

    Description
    NM_152941.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein. Exon 9 splice donor site lacks transcript support. CDS also frameshifted from codons 647-658 due to a 1 nt gap and a 1 nt insert.
Nucleotide Protein Strain
Heading Accession and Version

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