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prc1a protein regulator of cytokinesis 1a [ Danio rerio (zebrafish) ]

Gene ID: 259194, updated on 2-Nov-2024

Summary

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Official Symbol
prc1aprovided by ZNC
Official Full Name
protein regulator of cytokinesis 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020801-3
See related
Ensembl:ENSDARG00000100918 AllianceGenome:ZFIN:ZDB-GENE-020801-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
prc1; cb212; prc1l; zgc:55982; zgc:86918
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in mitotic spindle midzone assembly. Predicted to be active in cytoplasm and mitotic spindle midzone. Is expressed in margin and proliferative region. Orthologous to human PRC1 (protein regulator of cytokinesis 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See prc1a in Genome Data Viewer
Location:
chromosome: 25
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (7435214..7459027)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (7261095..7285297)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene pseudopodium-enriched atypical kinase 1 Neighboring gene ubiquitin associated protein 1-like a Neighboring gene synaptotagmin XII Neighboring gene catalase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The midbody component Prc1-like is required for microtubule reorganization during cytokinesis and dorsal determinant segregation in the early zebrafish embryo. Nair S, et al. Development, 2023 Feb 15. PMID 36789950, Free PMC Article
  2. Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish. Chen J, et al. Sci China Life Sci, 2021 Dec. PMID 33751369
  3. Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. O'Hare EA, et al. Mol Endocrinol, 2016 Apr. PMID 26963759, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The midbody component Prc1-like is required for microtubule reorganization during cytokinesis and dorsal determinant segregation in the early zebrafish embryo.
    Title: The midbody component Prc1-like is required for microtubule reorganization during cytokinesis and dorsal determinant segregation in the early zebrafish embryo.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC55982

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle midzone assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein regulator of cytokinesis 1a
Names
protein regulator of cytokinesis 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004494.1 → NP_001004494.1  protein regulator of cytokinesis 1a

    See identical proteins and their annotated locations for NP_001004494.1

    Status: PROVISIONAL

    Source sequence(s)
    BC075789
    UniProtKB/TrEMBL
    A0A8M1N1Z4, Q6DI02
    Related
    ENSDARP00000139061.1, ENSDART00000172567.2
    Conserved Domains (2) summary
    pfam03999
    Location:37 → 578
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00278
    Location:19 → 71
    CCC1_like; CCC1-related family of proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    7435214..7459027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068217306.1 → XP_068073407.1  protein regulator of cytokinesis 1a isoform X3

  2. XM_009297767.3 → XP_009296042.1  protein regulator of cytokinesis 1a isoform X4

    UniProtKB/TrEMBL
    A0A0R4IC50, A0A8M3AWC0
    Related
    ENSDARP00000130445.1, ENSDART00000163017.2
    Conserved Domains (2) summary
    pfam03999
    Location:37 → 586
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00278
    Location:19 → 71
    CCC1_like; CCC1-related family of proteins

  3. XM_021470440.2 → XP_021326115.1  protein regulator of cytokinesis 1a isoform X1

    UniProtKB/TrEMBL
    A0A8M9PY83
    Conserved Domains (1) summary
    pfam03999
    Location:37 → 578
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

  4. XM_068217305.1 → XP_068073406.1  protein regulator of cytokinesis 1a isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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