U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dclre1c DNA cross-link repair 1C [ Rattus norvegicus (Norway rat) ]

Gene ID: 259171, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Dclre1cprovided by RGD
Official Full Name
DNA cross-link repair 1Cprovided by RGD
Primary source
RGD:708574
See related
EnsemblRapid:ENSRNOG00000015980 AllianceGenome:RGD:708574
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Snm1l
Summary
Predicted to enable 5'-3' DNA exonuclease activity; damaged DNA binding activity; and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in double-strand break repair via nonhomologous end joining; interstrand cross-link repair; and telomere maintenance. Predicted to act upstream of or within several processes, including B cell differentiation; DNA metabolic process; and response to ionizing radiation. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be part of nonhomologous end joining complex. Human ortholog(s) of this gene implicated in Omenn syndrome; common variable immunodeficiency; severe combined immunodeficiency; and severe combined immunodeficiency with sensitivity to ionizing radiation. Orthologous to human DCLRE1C (DNA cross-link repair 1C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 492.9), Spleen (RPKM 85.8) and 5 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dclre1c in Genome Data Viewer
Location:
17q12.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (79684988..79718399, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (74775828..74810089, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (78782512..78812140, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene Myb/SANT DNA binding domain containing 7 Neighboring gene heat shock protein family A (Hsp70) member 14 Neighboring gene uncharacterized LOC120097881 Neighboring gene SUV39H2 histone lysine methyltransferase Neighboring gene metallothionein 1, pseudogene 3 Neighboring gene meiosis/spermiogenesis associated 1 Neighboring gene uncharacterized LOC120097878

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. DCLRE1C (ARTEMIS) mutations causing phenotypes ranging from atypical severe combined immunodeficiency to mere antibody deficiency. Volk T, et al. Hum Mol Genet, 2015 Dec 20. PMID 26476407, Free PMC Article
  2. Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. Rooney S, et al. J Exp Med, 2003 Mar 3. PMID 12615897, Free PMC Article
  3. Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice. Rooney S, et al. Mol Cell, 2002 Dec. PMID 12504013
  4. Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. Moshous D, et al. Cell, 2001 Apr 20. PMID 11336668
  5. Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Ma Y, et al. Cell, 2002 Mar 22. PMID 11955432

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 5'-3' DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-3' exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables 5'-3' exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA endodeoxyribonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA endodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in B cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in V(D)J recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within V(D)J recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within chromosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of nonhomologous end joining complex IEA
Inferred from Electronic Annotation
more info
  
part_of nonhomologous end joining complex ISO
Inferred from Sequence Orthology
more info
  
part_of nonhomologous end joining complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein artemis
Names
DNA cross-link repair 1C protein
SNM1-like protein
NP_671486.2
XP_038951343.1
XP_063132185.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_147145.2 → NP_671486.2  protein artemis

    See identical proteins and their annotated locations for NP_671486.2

    Status: PROVISIONAL

    Source sequence(s)
    BC083546
    UniProtKB/Swiss-Prot
    Q5XIX3, Q8K4H7
    UniProtKB/TrEMBL
    A0A8L2QAU1
    Related
    ENSRNOP00000102035.1, ENSRNOT00000163213.1
    Conserved Domains (2) summary
    pfam07522
    Location:239 → 343
    DRMBL; DNA repair metallo-beta-lactamase
    cd16297
    Location:1 → 171
    artemis-SNM1C-like_MBL-fold; artemis-SNM1C and related proteins; MBL-fold metallo-hydrolase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    79684988..79718399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276115.1 → XP_063132185.1  protein artemis isoform X1

    UniProtKB/TrEMBL
    A6JM16

  2. XM_039095415.2 → XP_038951343.1  protein artemis isoform X1

    UniProtKB/TrEMBL
    A6JM16
    Conserved Domains (3) summary
    pfam07522
    Location:93 → 197
    DRMBL; DNA repair metallo-beta-lactamase
    NF033845
    Location:275 → 520
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    cl23716
    Location:1 → 25
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

RNA

  1. XR_010058810.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIX3.1 GenPept UniProtKB/Swiss-Prot:Q5XIX3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous