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MXRA5 matrix remodeling associated 5 [ Homo sapiens (human) ]

Gene ID: 25878, updated on 5-Mar-2024

Summary

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Official Symbol
MXRA5provided by HGNC
Official Full Name
matrix remodeling associated 5provided by HGNC
Primary source
HGNC:HGNC:7539
See related
Ensembl:ENSG00000101825 MIM:300938; AllianceGenome:HGNC:7539
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes one of the matrix-remodelling associated proteins. This protein contains 7 leucine-rich repeats and 12 immunoglobulin-like C2-type domains related to perlecan. This gene has a pseudogene on chromosome Y. [provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in skin (RPKM 16.1), urinary bladder (RPKM 11.0) and 22 other tissues See more
Orthologs
all
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Genomic context

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Location:
Xp22.33
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (3308565..3346652, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (2922161..2960959, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (3226606..3264693, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S24 pseudogene 21 Neighboring gene MPRA-validated peak7351 silencer Neighboring gene NANOG hESC enhancer GRCh37_chrX:3102859-3103394 Neighboring gene long intergenic non-protein coding RNA 1546 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:3280933-3281483 Neighboring gene argininosuccinate synthetase 1 pseudogene 4 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:3445471-3446670 Neighboring gene small nucleolar RNA, H/ACA box 48B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MXRA5 Is a Novel Immune-Related Biomarker That Predicts Poor Prognosis in Glioma. Sun JZ, et al. Dis Markers, 2021. PMID 34211612, Free PMC Article
  2. Identification and functional activity of matrix-remodeling associated 5 (MXRA5) in benign hyperplastic prostate. Xiao H, et al. Aging (Albany NY), 2020 May 11. PMID 32392178, Free PMC Article
  3. MXRA5 is decreased in preeclampsia and affects trophoblast cell invasion through the MAPK pathway. Ding L, et al. Mol Cell Endocrinol, 2018 Feb 5. PMID 28919298
  4. MXRA5 is a TGF-β1-regulated human protein with anti-inflammatory and anti-fibrotic properties. Poveda J, et al. J Cell Mol Med, 2017 Jan. PMID 27599751, Free PMC Article
  5. Matrix-remodeling associated 5 as a novel tissue biomarker predicts poor prognosis in non-small cell lung cancers. He Y, et al. Cancer Biomark, 2015. PMID 26406953

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Public RNA-seq data-based identification and functional analyses reveal that MXRA5 retains proliferative and migratory abilities of dental pulp stem cells.
    Title: Public RNA-seq data-based identification and functional analyses reveal that MXRA5 retains proliferative and migratory abilities of dental pulp stem cells.
  2. MXRA5 Is a Novel Immune-Related Biomarker That Predicts Poor Prognosis in Glioma.
    Title: MXRA5 Is a Novel Immune-Related Biomarker That Predicts Poor Prognosis in Glioma.
  3. Identification and functional activity of matrix-remodeling associated 5 (MXRA5) in benign hyperplastic prostate.
    Title: Identification and functional activity of matrix-remodeling associated 5 (MXRA5) in benign hyperplastic prostate.
  4. MXRA5 is downregulated in preeclamptic cytotrophoblasts and can regulate trophoblast cell invasion via the MAPK pathway.
    Title: MXRA5 is decreased in preeclampsia and affects trophoblast cell invasion through the MAPK pathway.
  5. In clear cell renal cancer, von Hippel-Lindau (VHL) regulated MXRA5 expression.
    Title: MXRA5 is a TGF-β1-regulated human protein with anti-inflammatory and anti-fibrotic properties.
  6. These results indicated the potential value of MXRA5 as a novel therapeutic target for the treatment of non-small cell lung cancer.
    Title: Matrix-remodeling associated 5 as a novel tissue biomarker predicts poor prognosis in non-small cell lung cancers.
  7. screened one most frequently mutated novel gene, matrix-remodeling associated 5 (MXRA5), in an additional larger Chinese sample set of 52 patients with NSCLC and confirmed its high somatic mutation frequency
    Title: Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetically distinct subsets within ANCA-associated vasculitis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp564I1922

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables extracellular matrix structural constituent HDA PubMed 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to transforming growth factor beta IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to transforming growth factor beta IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
matrix-remodeling-associated protein 5
Names
adhesion protein with leucine-rich repeats and Immunoglobulin domains related to perlecan
adlican
matrix-remodelling associated 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021336.1 RefSeqGene

    Range
    4992..43079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015419.4 → NP_056234.2  matrix-remodeling-associated protein 5 precursor

    See identical proteins and their annotated locations for NP_056234.2

    Status: REVIEWED

    Source sequence(s)
    AC004616, AF245505, BC064986, CD626974
    Consensus CDS
    CCDS14124.1
    UniProtKB/Swiss-Prot
    Q6P1M7, Q9NR99, Q9Y3Y8
    Related
    ENSP00000217939.5, ENST00000217939.7
    Conserved Domains (10) summary
    cd00096
    Location:2751 → 2824
    Ig; Immunoglobulin domain
    smart00408
    Location:1965 → 2032
    IGc2; Immunoglobulin C-2 Type
    smart00082
    Location:217 → 263
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:2549 → 2633
    IG; Immunoglobulin
    smart00410
    Location:2356 → 2435
    IG_like; Immunoglobulin like
    pfam07679
    Location:1958 → 2042
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:38 → 55
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:128 → 168
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:102 → 163
    LRR_8; Leucine rich repeat
    cl11960
    Location:2361 → 2435
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    3308565..3346652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    2922161..2960959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NR99.3 GenPept UniProtKB/Swiss-Prot:Q9NR99

Gene LinkOut

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