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Chrng cholinergic receptor nicotinic gamma subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 25753, updated on 17-Aug-2024

Summary

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Official Symbol
Chrngprovided by RGD
Official Full Name
cholinergic receptor nicotinic gamma subunitprovided by RGD
Primary source
RGD:2354
See related
EnsemblRapid:ENSRNOG00000077483 AllianceGenome:RGD:2354
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ACHRG
Summary
Enables acetylcholine-gated cation-selective channel activity. Involved in cation transport and skeletal muscle contraction. Part of acetylcholine-gated channel complex. Human ortholog(s) of this gene implicated in multiple pterygium syndrome. Orthologous to human CHRNG (cholinergic receptor nicotinic gamma subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 5.1), Muscle (RPKM 3.4) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Chrng in Genome Data Viewer
Location:
9q35
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (95325984..95332092)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (87878085..87884193)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (94302218..94308591)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene serine protease 56 Neighboring gene cholinergic receptor nicotinic delta subunit Neighboring gene eukaryotic translation initiation factor 4E family member 2 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Differential regulation of muscle acetylcholine receptor gamma- and epsilon-subunit mRNAs. Witzemann V, et al. FEBS Lett, 1987 Oct 19. PMID 3666131
  2. A novel mode-of-action mediated by the fetal muscle nicotinic acetylcholine receptor resulting in developmental toxicity in rats. Rasoulpour RJ, et al. Toxicol Sci, 2012 Jun. PMID 22461452
  3. The acetylcholine receptor gamma-to-epsilon switch occurs in individual endplates. Yumoto N, et al. Biochem Biophys Res Commun, 2005 Jun 17. PMID 15883046
  4. Primary structure and functional expression of the alpha-, beta-, gamma-, delta- and epsilon-subunits of the acetylcholine receptor from rat muscle. Witzemann V, et al. Eur J Biochem, 1990 Dec 12. PMID 1702709
  5. Involvement of the chaperone protein calnexin and the acetylcholine receptor beta-subunit in the assembly and cell surface expression of the receptor. Keller SH, et al. J Biol Chem, 1996 Sep 13. PMID 8798466

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetylcholine-gated monoatomic cation-selective channel activity IEA
Inferred from Electronic Annotation
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity ISO
Inferred from Sequence Orthology
more info
  
enables ligand-gated monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane depolarization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle contraction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic transmission, cholinergic IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of acetylcholine-gated channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of acetylcholine-gated channel complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
acetylcholine receptor subunit gamma
Names
AChR gamma subunit
cholinergic receptor, nicotinic gamma
cholinergic receptor, nicotinic, gamma (muscle)
cholinergic receptor, nicotinic, gamma polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019145.1 → NP_062018.1  acetylcholine receptor subunit gamma precursor

    See identical proteins and their annotated locations for NP_062018.1

    Status: PROVISIONAL

    Source sequence(s)
    X74834
    UniProtKB/Swiss-Prot
    P18916
    UniProtKB/TrEMBL
    A0A8I6A2R4, A6JWL3
    Related
    ENSRNOP00000085634.1, ENSRNOT00000106438.2
    Conserved Domains (2) summary
    cd19029
    Location:49 → 241
    LGIC_ECD_nAChR_G; extracellular domain of nicotinic acetylcholine receptor subunit gamma (CHRNG)
    pfam02932
    Location:248 → 494
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    95325984..95332092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18916.2 GenPept UniProtKB/Swiss-Prot:P18916

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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