Got2 glutamic-oxaloacetic transaminase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Got2provided by RGD
Official Full Name: glutamic-oxaloacetic transaminase 2provided by RGD
Primary source: RGD:2722
See related: EnsemblRapid:ENSRNOG00000011782 AllianceGenome:RGD:2722
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: mAAT; ASPATA
Summary: Enables several functions, including L-aspartate:2-oxoglutarate aminotransferase activity; anion binding activity; and identical protein binding activity. Involved in several processes, including dicarboxylic acid metabolic process; lactation; and response to insulin. Located in several cellular components, including T-tubule; mitochondrial inner membrane; and perikaryon. Part of protein-containing complex. Biomarker of acute kidney failure; neurodegenerative disease; obesity; and schizophrenia. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 82. Orthologous to human GOT2 (glutamic-oxaloacetic transaminase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 3056.2), Muscle (RPKM 2434.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (9180428..9206113)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (9174304..9199995)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (9587637..9613323)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Changes in glutamic oxaloacetic transaminase 2 during rat physiological and pathological cardiomyocyte hypertrophy.
Title: Changes in glutamic oxaloacetic transaminase 2 during rat physiological and pathological cardiomyocyte hypertrophy.
Ischemic Neuroprotectant PKCepsilon Restores Mitochondrial Glutamate Oxaloacetate Transaminase in the Neuronal NADH Shuttle after Ischemic Injury.
Title: Ischemic Neuroprotectant PKCε Restores Mitochondrial Glutamate Oxaloacetate Transaminase in the Neuronal NADH Shuttle after Ischemic Injury.
Contractions increase FABPpm protein content in skeletal muscle plasma membrane.
Title: Contractions but not AICAR increase FABPpm content in rat muscle sarcolemma.
Results suggest that downregulation of the endogenous SO(2)/GOT pathway is likely involved in the pathogenesis of ISO-induced myocardial injury.
Title: Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats.
unfolding of mitochondrial aspartate aminotransferase is a multi-step process which includes an intermediate containing bound PLP but lacking catalytic activity.
Title: Release of pyridoxal 5'-phosphate upon unfolding of mitochondrial aspartate aminotransferase.
study of the rate-limiting steps in the refolding of the cofactor-dependent protein aspartate aminotransferase
Title: The nature of the rate-limiting steps in the refolding of the cofactor-dependent protein aspartate aminotransferase.
Immunogold localization of mitochondrial aspartate aminotransferase in mitochondria and on the cell surface in normal rat tissues.
Title: Immunogold localization of mitochondrial aspartate aminotransferase in mitochondria and on the cell surface in normal rat tissues.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BI302995 (e-PCR)
- UniSTS:247897

RH94457 (e-PCR)
- UniSTS:119705

RH134496 (e-PCR)
- UniSTS:217776

UniSTS:235975 (e-PCR)
- UniSTS:235975

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-aspartate:2-oxoglutarate aminotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-aspartate:2-oxoglutarate aminotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-aspartate:2-oxoglutarate aminotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-aspartate:2-oxoglutarate aminotransferase activity	ISO Inferred from Sequence Orthology more info
enables L-aspartate:2-oxoglutarate aminotransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables amino acid binding	IDA Inferred from Direct Assay more info	PubMed
enables carboxylic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables kynurenine-oxoglutarate transaminase activity	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 2-oxoglutarate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-glutamate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in amino acid metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within aspartate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in aspartate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in aspartate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in aspartate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aspartate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dicarboxylic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in fatty acid transport	TAS Traceable Author Statement more info	PubMed
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within glutamate catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glutamate catabolic process to aspartate	ISO Inferred from Sequence Orthology more info
involved_in glutamate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lactation	IEP Inferred from Expression Pattern more info	PubMed
involved_in malate-aspartate shuttle	ISO Inferred from Sequence Orthology more info
involved_in oxaloacetate metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within oxaloacetate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	TAS Traceable Author Statement more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aspartate aminotransferase, mitochondrial

Names: FABP-1; FABPpm; Glutamate oxaloacetate transaminase 2, mitochondrial (aspartate aminotransferase 2); fatty acid-binding protein; glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); kynurenine aminotransferase 4; kynurenine aminotransferase IV; kynurenine--oxoglutarate transaminase 4; kynurenine--oxoglutarate transaminase IV; mAspAT; plasma membrane-associated fatty acid-binding protein; transaminase A

NP_037309.1

EC 2.6.1.1

EC 2.6.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.