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C19orf38 chromosome 19 open reading frame 38 [ Homo sapiens (human) ]

Gene ID: 255809, updated on 5-Mar-2024

Summary

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Official Symbol
C19orf38provided by HGNC
Official Full Name
chromosome 19 open reading frame 38provided by HGNC
Primary source
HGNC:HGNC:34073
See related
Ensembl:ENSG00000214212 AllianceGenome:HGNC:34073
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIDE1
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bone marrow (RPKM 25.7), spleen (RPKM 5.5) and 5 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
19p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10836685..10869790)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10963557..10996802)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10959091..10980466)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene dynamin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10945386-10946023 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10946661-10947297 Neighboring gene microRNA 6793 Neighboring gene HIKESHI pseudogene 2 Neighboring gene transmembrane p24 trafficking protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10973529-10974377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10093 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13997 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10984976-10985476 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10985477-10985977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13999 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10989664-10990506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10991348-10992190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10992191-10993032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10993033-10993874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10993875-10994715 Neighboring gene coactivator associated arginine methyltransferase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11004683-11005484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11009921-11010538 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11015702-11015889 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11031708-11031887 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11037946-11038648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11038649-11039349 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10096 Neighboring gene Yip1 domain family member 2 Neighboring gene translocase of inner mitochondrial membrane 29

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High throughput RNAi screening identifies ID1 as a synthetic sick/lethal gene interacting with the common TP53 mutation R175H. Imai H, et al. Oncol Rep, 2014 Mar. PMID 24378760, Free PMC Article
  2. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824
  3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein HIDE1
Names
Highly expressed in immature dendritic cell transcript 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136482.3 → NP_001129954.1  protein HIDE1 precursor

    See identical proteins and their annotated locations for NP_001129954.1

    Status: VALIDATED

    Source sequence(s)
    AC007565
    Consensus CDS
    CCDS45970.1
    UniProtKB/Swiss-Prot
    A8MVS5, B2RXI3
    Related
    ENSP00000380920.3, ENST00000397820.5
    Conserved Domains (1) summary
    pfam13895
    Location:17 → 91
    Ig_2; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    10836685..10869790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259846.6 → XP_005259903.1  protein HIDE1 isoform X1

    See identical proteins and their annotated locations for XP_005259903.1

    UniProtKB/Swiss-Prot
    A8MVS5, B2RXI3
    Conserved Domains (1) summary
    pfam13895
    Location:17 → 91
    Ig_2; Immunoglobulin domain

  2. XM_005259847.6 → XP_005259904.1  protein HIDE1 isoform X1

    See identical proteins and their annotated locations for XP_005259904.1

    UniProtKB/Swiss-Prot
    A8MVS5, B2RXI3
    Related
    ENSP00000468568.1, ENST00000592854.5
    Conserved Domains (1) summary
    pfam13895
    Location:17 → 91
    Ig_2; Immunoglobulin domain

  3. XM_047438562.1 → XP_047294518.1  protein HIDE1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    10963557..10996802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320449.1 → XP_054176424.1  protein HIDE1 isoform X1

    UniProtKB/Swiss-Prot
    A8MVS5, B2RXI3

  2. XM_054320451.1 → XP_054176426.1  protein HIDE1 isoform X2

  3. XM_054320450.1 → XP_054176425.1  protein HIDE1 isoform X1

    UniProtKB/Swiss-Prot
    A8MVS5, B2RXI3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8MVS5.2 GenPept UniProtKB/Swiss-Prot:A8MVS5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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