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Il1rl1 interleukin 1 receptor-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25556, updated on 2-Nov-2024

Summary

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Official Symbol
Il1rl1provided by RGD
Official Full Name
interleukin 1 receptor-like 1provided by RGD
Primary source
RGD:2894
See related
EnsemblRapid:ENSRNOG00000014835 AllianceGenome:RGD:2894
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
St2; FIT1; Fit-1
Summary
Predicted to enable interleukin-33 binding activity and interleukin-33 receptor activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to peptide; and negative regulation of cell population proliferation. Located in external side of plasma membrane and extracellular space. Biomarker of acute myocardial infarction and bacterial pneumonia. Human ortholog(s) of this gene implicated in asthma and coronary artery disease. Orthologous to human IL1RL1 (interleukin 1 receptor like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 50.7), Lung (RPKM 21.2) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Il1rl1 in Genome Data Viewer
Location:
9q22
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (50157326..50222888)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (42661694..42727266)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (47133483..47184316)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor type 1 Neighboring gene interleukin 1 receptor-like 2 Neighboring gene interleukin 18 receptor 1 Neighboring gene interleukin 18 receptor accessory protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inhibition of T1/ST2 during respiratory syncytial virus infection prevents T helper cell type 2 (Th2)- but not Th1-driven immunopathology. Walzl G, et al. J Exp Med, 2001 Apr 2. PMID 11283151, Free PMC Article
  2. Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation. Oshikawa K, et al. Am J Respir Crit Care Med, 2001 Jul 15. PMID 11463601
  3. The increase in serum soluble ST2 protein upon acute exacerbation of idiopathic pulmonary fibrosis. Tajima S, et al. Chest, 2003 Oct. PMID 14555548
  4. The IL-33/ST2 Axis in Immune Responses Against Parasitic Disease: Potential Therapeutic Applications. Ryan N, et al. Front Cell Infect Microbiol, 2020. PMID 32363166, Free PMC Article
  5. Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway. Kearley J, et al. Am J Respir Crit Care Med, 2009 May 1. PMID 19179489, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence.
    Title: Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence.
  2. Electroacupuncture prevents the development or establishment of chronic pain via IL-33/ST2 signaling in hyperalgesic priming model rats.
    Title: Electroacupuncture prevents the development or establishment of chronic pain via IL-33/ST2 signaling in hyperalgesic priming model rats.
  3. Unveiling IL-33/ST2 Pathway Unbalance in Cardiac Remodeling Due to Obesity in Zucker Fatty Rats.
    Title: Unveiling IL-33/ST2 Pathway Unbalance in Cardiac Remodeling Due to Obesity in Zucker Fatty Rats.
  4. ST2 silencing aggravates ventricular remodeling and chronic heart failure in rats by mediating the IL-33/ST2 axis.
    Title: ST2 silencing aggravates ventricular remodeling and chronic heart failure in rats by mediating the IL-33/ST2 axis.
  5. MicroRNA-547-5p-mediated interleukin-33/suppressor of tumorigenicity 2 signaling underlies the genesis and maintenance of neuropathic pain and is targeted by the therapy with bone marrow stromal cells.
    Title: MicroRNA-547-5p-mediated interleukin-33/suppressor of tumorigenicity 2 signaling underlies the genesis and maintenance of neuropathic pain and is targeted by the therapy with bone marrow stromal cells.
  6. he transcription factor Yy1 regulates sST2 expression, and repression of Yy1 by metformin results in lower levels of sST2 that are associated with favorable myocardial remodeling. The manipulation of YY1 or its co-repressor HDAC4 emerge as new targets to modulate ST2/IL33 signaling and prevent adverse cardiac remodeling.
    Title: Yin-Yang 1 transcription factor modulates ST2 expression during adverse cardiac remodeling post-myocardial infarction.
  7. Calycosin treatment markedly improved the aforementioned makers of renal injury and dysfunction, modulated IL33/ST2 signaling.
    Title: Renoprotective effect of calycosin in high fat diet-fed/STZ injected rats: Effect on IL-33/ST2 signaling, oxidative stress and fibrosis suppression.
  8. The lungs are a relevant source of sST2 in heart failure, shich may have implications for disease progression.
    Title: Pulmonary Production of Soluble ST2 in Heart Failure.
  9. ST2/IL-33 signaling plays an important role in the development of radicular pain in lumbar disk herniation.
    Title: IL-33/ST2 signaling contributes to radicular pain by modulating MAPK and NF-κB activation and inflammatory mediator expression in the spinal cord in rat models of noncompressive lumber disk herniation.
  10. administration of sST2 significantly attenuated the severity of severe acute pancreatitis and associated cardiac damage, and the cardioprotective effect is associated with its anti-inflammatory action
    Title: Adenovirus-mediated overexpression of sST2 attenuates cardiac injury in the rat with severe acute pancreatitis.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1 receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-33 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-33 binding IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-33 binding ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-33 receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-33 receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to peptide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in interleukin-33-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-33-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-33-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in macrophage differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in macrophage differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in macrophage differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of T-helper 1 type immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of T-helper 1 type immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of type II interferon production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chemokine production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-5 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-5 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of macrophage activation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of macrophage activation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interleukin-1 receptor-like 1
Names
fos-responsive gene 1 protein
NP_001121161.1
NP_037169.1
XP_006244801.1
XP_006244802.1
XP_008765214.1
XP_017451779.1
XP_038938998.1
XP_038938999.1
XP_038939000.1
XP_038939001.1
XP_063122776.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127689.1 → NP_001121161.1  interleukin-1 receptor-like 1 isoform Fit-1M precursor

    See identical proteins and their annotated locations for NP_001121161.1

    Status: PROVISIONAL

    Source sequence(s)
    U04317
    UniProtKB/Swiss-Prot
    Q62611, Q62612
    UniProtKB/TrEMBL
    F1LR63
    Conserved Domains (4) summary
    cd05757
    Location:123 → 210
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00410
    Location:31 → 110
    IG_like; Immunoglobulin like
    pfam01582
    Location:384 → 539
    TIR; TIR domain
    cl11960
    Location:28 → 110
    Ig; Immunoglobulin domain

  2. NM_013037.1 → NP_037169.1  interleukin-1 receptor-like 1 isoform Fit-1S precursor

    See identical proteins and their annotated locations for NP_037169.1

    Status: PROVISIONAL

    Source sequence(s)
    U04319
    UniProtKB/Swiss-Prot
    Q62611
    Related
    ENSRNOP00000103721.1, ENSRNOT00000136818.1
    Conserved Domains (3) summary
    cd05757
    Location:123 → 210
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00410
    Location:31 → 110
    IG_like; Immunoglobulin like
    cl11960
    Location:28 → 110
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    50157326..50222888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083070.2 → XP_038938998.1  interleukin-1 receptor-like 1 isoform X1

    UniProtKB/TrEMBL
    F1LR63
    Conserved Domains (4) summary
    pfam01582
    Location:384 → 539
    TIR; TIR domain
    cd00096
    Location:37 → 42
    Ig; Ig strand B [structural motif]
    cd05757
    Location:123 → 210
    Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:33 → 110
    Ig; Immunoglobulin domain

  2. XM_039083072.2 → XP_038939000.1  interleukin-1 receptor-like 1 isoform X1

    UniProtKB/TrEMBL
    F1LR63
    Related
    ENSRNOP00000020108.5, ENSRNOT00000020108.7
    Conserved Domains (4) summary
    pfam01582
    Location:384 → 539
    TIR; TIR domain
    cd00096
    Location:37 → 42
    Ig; Ig strand B [structural motif]
    cd05757
    Location:123 → 210
    Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:33 → 110
    Ig; Immunoglobulin domain

  3. XM_008766992.4 → XP_008765214.1  interleukin-1 receptor-like 1 isoform X1

    See identical proteins and their annotated locations for XP_008765214.1

    UniProtKB/TrEMBL
    F1LR63
    Conserved Domains (4) summary
    pfam01582
    Location:384 → 539
    TIR; TIR domain
    cd00096
    Location:37 → 42
    Ig; Ig strand B [structural motif]
    cd05757
    Location:123 → 210
    Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:33 → 110
    Ig; Immunoglobulin domain

  4. XM_006244740.5 → XP_006244802.1  interleukin-1 receptor-like 1 isoform X1

    See identical proteins and their annotated locations for XP_006244802.1

    UniProtKB/TrEMBL
    F1LR63
    Conserved Domains (4) summary
    pfam01582
    Location:384 → 539
    TIR; TIR domain
    cd00096
    Location:37 → 42
    Ig; Ig strand B [structural motif]
    cd05757
    Location:123 → 210
    Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:33 → 110
    Ig; Immunoglobulin domain

  5. XM_063266706.1 → XP_063122776.1  interleukin-1 receptor-like 1 isoform X1

  6. XM_006244739.5 → XP_006244801.1  interleukin-1 receptor-like 1 isoform X1

    See identical proteins and their annotated locations for XP_006244801.1

    UniProtKB/TrEMBL
    F1LR63
    Conserved Domains (4) summary
    pfam01582
    Location:384 → 539
    TIR; TIR domain
    cd00096
    Location:37 → 42
    Ig; Ig strand B [structural motif]
    cd05757
    Location:123 → 210
    Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:33 → 110
    Ig; Immunoglobulin domain

  7. XM_039083071.2 → XP_038938999.1  interleukin-1 receptor-like 1 isoform X1

    UniProtKB/TrEMBL
    F1LR63
    Conserved Domains (4) summary
    pfam01582
    Location:384 → 539
    TIR; TIR domain
    cd00096
    Location:37 → 42
    Ig; Ig strand B [structural motif]
    cd05757
    Location:123 → 210
    Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:33 → 110
    Ig; Immunoglobulin domain

  8. XM_017596290.3 → XP_017451779.1  interleukin-1 receptor-like 1 isoform X1

    UniProtKB/TrEMBL
    F1LR63
    Conserved Domains (4) summary
    pfam01582
    Location:384 → 539
    TIR; TIR domain
    cd00096
    Location:37 → 42
    Ig; Ig strand B [structural motif]
    cd05757
    Location:123 → 210
    Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:33 → 110
    Ig; Immunoglobulin domain

  9. XM_039083073.2 → XP_038939001.1  interleukin-1 receptor-like 1 isoform X1

    UniProtKB/TrEMBL
    F1LR63
    Conserved Domains (4) summary
    pfam01582
    Location:384 → 539
    TIR; TIR domain
    cd00096
    Location:37 → 42
    Ig; Ig strand B [structural motif]
    cd05757
    Location:123 → 210
    Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:33 → 110
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62611.1 GenPept UniProtKB/Swiss-Prot:Q62611

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