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ZDHHC23 zinc finger DHHC-type palmitoyltransferase 23 [ Homo sapiens (human) ]

Gene ID: 254887, updated on 3-Apr-2024

Summary

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Official Symbol
ZDHHC23provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 23provided by HGNC
Primary source
HGNC:HGNC:28654
See related
Ensembl:ENSG00000184307 MIM:617334; AllianceGenome:HGNC:28654
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIDD; DHHC-23
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in protein localization to plasma membrane and protein palmitoylation. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 5.9), colon (RPKM 3.9) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
3q13.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (113947901..113979508)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (116669165..116719588)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (113666748..113682220)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene GRAM domain containing 1C Neighboring gene CTDNEP1 pseudogene 1 Neighboring gene VPS26A pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:113666278-113666778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14613 Neighboring gene coiled-coil domain containing 191 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20265 Neighboring gene ATP5PB pseudogene 8 Neighboring gene uncharacterized LOC105374048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20267

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. Ellinghaus D, et al. Am J Hum Genet, 2012 Apr 6. PMID 22482804, Free PMC Article
  2. NIDD, a novel DHHC-containing protein, targets neuronal nitric-oxide synthase (nNOS) to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity. Saitoh F, et al. J Biol Chem, 2004 Jul 9. PMID 15105416
  3. Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels. Tian L, et al. J Biol Chem, 2012 Apr 27. PMID 22399288, Free PMC Article
  4. DHHC protein family targets different subsets of glioma stem cells in specific niches. Chen X, et al. J Exp Clin Cancer Res, 2019 Jan 18. PMID 30658672, Free PMC Article
  5. Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. Wistow G, et al. Mol Vis, 2002 Jun 15. PMID 12107410

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC42530

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein palmitoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC23
Names
zinc finger DHHC domain-containing protein 23
zinc finger DHHC-type containing 23
NP_001307395.1
NP_001307396.1
NP_001307397.1
NP_001350881.1
NP_775841.2
XP_005247326.1
XP_005247327.1
XP_006713625.1
XP_011510920.1
XP_011510921.1
XP_016861573.1
XP_016861575.1
XP_016861576.1
XP_047303838.1
XP_047303839.1
XP_047303841.1
XP_047303842.1
XP_047303843.1
XP_047303844.1
XP_047303846.1
XP_047303847.1
XP_047303848.1
XP_047303849.1
XP_047303850.1
XP_047303851.1
XP_054201962.1
XP_054201963.1
XP_054201964.1
XP_054201965.1
XP_054201966.1
XP_054201967.1
XP_054201968.1
XP_054201969.1
XP_054201970.1
XP_054201971.1
XP_054201972.1
XP_054201973.1
XP_054201974.1
XP_054201975.1
XP_054201976.1
XP_054201977.1
XP_054201978.1
XP_054201979.1
XP_054201980.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320466.2 → NP_001307395.1  palmitoyltransferase ZDHHC23 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC128687
    Consensus CDS
    CCDS93341.1
    UniProtKB/TrEMBL
    A0A1W2PRJ8, B3KXB3
    Related
    ENSP00000492287.2, ENST00000638807.2
    Conserved Domains (2) summary
    pfam01529
    Location:258 → 384
    zf-DHHC; DHHC palmitoyltransferase
    pfam03203
    Location:96 → 151
    MerC; MerC mercury resistance protein

  2. NM_001320467.2 → NP_001307396.1  palmitoyltransferase ZDHHC23 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC128687
    Consensus CDS
    CCDS93341.1
    UniProtKB/TrEMBL
    A0A1W2PRJ8, B3KXB3
    Conserved Domains (2) summary
    pfam01529
    Location:258 → 384
    zf-DHHC; DHHC palmitoyltransferase
    pfam03203
    Location:96 → 151
    MerC; MerC mercury resistance protein

  3. NM_001320468.2 → NP_001307397.1  palmitoyltransferase ZDHHC23 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC128687
    UniProtKB/TrEMBL
    B3KXB3
    Conserved Domains (2) summary
    pfam01529
    Location:258 → 381
    zf-DHHC; DHHC palmitoyltransferase
    pfam03203
    Location:96 → 151
    MerC; MerC mercury resistance protein

  4. NM_001363952.1 → NP_001350881.1  palmitoyltransferase ZDHHC23 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC128687
    Consensus CDS
    CCDS87122.1
    UniProtKB/TrEMBL
    B3KXB3, E9PAP7
    Conserved Domains (2) summary
    pfam01529
    Location:258 → 384
    zf-DHHC; DHHC palmitoyltransferase
    cl03934
    Location:96 → 151
    MerC; MerC mercury resistance protein

  5. NM_173570.5 → NP_775841.2  palmitoyltransferase ZDHHC23 isoform c

    See identical proteins and their annotated locations for NP_775841.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and the 3' structure, resulting in a distinct 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus, and is shorter, compared to isoform a.
    Source sequence(s)
    AC128687, AF131818, AK127996, BC035230, CA389626
    Consensus CDS
    CCDS33827.1
    UniProtKB/Swiss-Prot
    D3DN76, Q8IYP9
    UniProtKB/TrEMBL
    B3KXV3
    Related
    ENSP00000330485.3, ENST00000330212.7
    Conserved Domains (2) summary
    pfam01529
    Location:258 → 384
    zf-DHHC; DHHC palmitoyltransferase
    pfam03203
    Location:96 → 151
    MerC; MerC mercury resistance protein

RNA

  1. NR_135271.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has a different 3' structure compared to variant 1. This variant is represented as non-coding because the use of the 5' most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC128687, AK127025, BC035230, CA389626

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    113947901..113979508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447885.1 → XP_047303841.1  palmitoyltransferase ZDHHC23 isoform X3

  2. XM_006713562.4 → XP_006713625.1  palmitoyltransferase ZDHHC23 isoform X3

    UniProtKB/TrEMBL
    B3KXB3
    Conserved Domains (2) summary
    pfam01529
    Location:258 → 384
    zf-DHHC; DHHC palmitoyltransferase
    pfam03203
    Location:96 → 151
    MerC; MerC mercury resistance protein

  3. XM_047447886.1 → XP_047303842.1  palmitoyltransferase ZDHHC23 isoform X3

  4. XM_047447887.1 → XP_047303843.1  palmitoyltransferase ZDHHC23 isoform X4

    UniProtKB/TrEMBL
    E9PAP7

  5. XM_047447883.1 → XP_047303839.1  palmitoyltransferase ZDHHC23 isoform X2

  6. XM_047447890.1 → XP_047303846.1  palmitoyltransferase ZDHHC23 isoform X5

  7. XM_047447895.1 → XP_047303851.1  palmitoyltransferase ZDHHC23 isoform X10

  8. XM_047447882.1 → XP_047303838.1  palmitoyltransferase ZDHHC23 isoform X1

    UniProtKB/TrEMBL
    A0A1W2PRJ8

  9. XM_047447891.1 → XP_047303847.1  palmitoyltransferase ZDHHC23 isoform X6

    UniProtKB/Swiss-Prot
    D3DN76, Q8IYP9

  10. XM_047447893.1 → XP_047303849.1  palmitoyltransferase ZDHHC23 isoform X8

  11. XM_011512619.2 → XP_011510921.1  palmitoyltransferase ZDHHC23 isoform X4

    UniProtKB/TrEMBL
    B3KXB3, E9PAP7
    Related
    ENSP00000420251.1, ENST00000478793.1
    Conserved Domains (2) summary
    pfam01529
    Location:258 → 384
    zf-DHHC; DHHC palmitoyltransferase
    cl03934
    Location:96 → 151
    MerC; MerC mercury resistance protein

  12. XM_005247269.2 → XP_005247326.1  palmitoyltransferase ZDHHC23 isoform X6

    See identical proteins and their annotated locations for XP_005247326.1

    UniProtKB/Swiss-Prot
    D3DN76, Q8IYP9
    UniProtKB/TrEMBL
    B3KXV3
    Related
    ENSP00000417840.1, ENST00000498275.5
    Conserved Domains (2) summary
    pfam01529
    Location:258 → 384
    zf-DHHC; DHHC palmitoyltransferase
    pfam03203
    Location:96 → 151
    MerC; MerC mercury resistance protein

  13. XM_017006087.2 → XP_016861576.1  palmitoyltransferase ZDHHC23 isoform X5

    UniProtKB/TrEMBL
    B3KXB3

  14. XM_017006086.2 → XP_016861575.1  palmitoyltransferase ZDHHC23 isoform X7

    UniProtKB/TrEMBL
    B3KXV3

  15. XM_011512618.3 → XP_011510920.1  palmitoyltransferase ZDHHC23 isoform X1

    See identical proteins and their annotated locations for XP_011510920.1

    UniProtKB/TrEMBL
    A0A1W2PRJ8, B3KXB3
    Conserved Domains (2) summary
    pfam01529
    Location:258 → 384
    zf-DHHC; DHHC palmitoyltransferase
    pfam03203
    Location:96 → 151
    MerC; MerC mercury resistance protein

  16. XM_047447888.1 → XP_047303844.1  palmitoyltransferase ZDHHC23 isoform X4

    UniProtKB/TrEMBL
    E9PAP7

  17. XM_047447892.1 → XP_047303848.1  palmitoyltransferase ZDHHC23 isoform X6

    UniProtKB/Swiss-Prot
    D3DN76, Q8IYP9

  18. XM_017006084.2 → XP_016861573.1  palmitoyltransferase ZDHHC23 isoform X2

    UniProtKB/TrEMBL
    B3KXB3
    Conserved Domains (2) summary
    pfam01529
    Location:258 → 381
    zf-DHHC; DHHC palmitoyltransferase
    pfam03203
    Location:96 → 151
    MerC; MerC mercury resistance protein

  19. XM_005247270.4 → XP_005247327.1  palmitoyltransferase ZDHHC23 isoform X8

    Conserved Domains (1) summary
    pfam01529
    Location:97 → 223
    zf-DHHC; DHHC palmitoyltransferase

  20. XM_047447894.1 → XP_047303850.1  palmitoyltransferase ZDHHC23 isoform X9

RNA

  1. XR_001740081.2 RNA Sequence

  2. XR_007095654.1 RNA Sequence

  3. XR_924119.2 RNA Sequence

  4. XR_007095655.1 RNA Sequence

  5. XR_007095657.1 RNA Sequence

  6. XR_007095656.1 RNA Sequence

  7. XR_007095658.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    116669165..116719588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345992.1 → XP_054201967.1  palmitoyltransferase ZDHHC23 isoform X3

  2. XM_054345991.1 → XP_054201966.1  palmitoyltransferase ZDHHC23 isoform X3

  3. XM_054345996.1 → XP_054201971.1  palmitoyltransferase ZDHHC23 isoform X4

    UniProtKB/TrEMBL
    E9PAP7

  4. XM_054345989.1 → XP_054201964.1  palmitoyltransferase ZDHHC23 isoform X2

  5. XM_054345999.1 → XP_054201974.1  palmitoyltransferase ZDHHC23 isoform X5

  6. XM_054346005.1 → XP_054201980.1  palmitoyltransferase ZDHHC23 isoform X10

  7. XM_054345988.1 → XP_054201963.1  palmitoyltransferase ZDHHC23 isoform X1

    UniProtKB/TrEMBL
    A0A1W2PRJ8

  8. XM_054346000.1 → XP_054201975.1  palmitoyltransferase ZDHHC23 isoform X6

    UniProtKB/Swiss-Prot
    D3DN76, Q8IYP9

  9. XM_054346002.1 → XP_054201977.1  palmitoyltransferase ZDHHC23 isoform X8

  10. XM_054345993.1 → XP_054201968.1  palmitoyltransferase ZDHHC23 isoform X4

    UniProtKB/TrEMBL
    E9PAP7

  11. XM_054345995.1 → XP_054201970.1  palmitoyltransferase ZDHHC23 isoform X6

    UniProtKB/Swiss-Prot
    D3DN76, Q8IYP9

  12. XM_054345994.1 → XP_054201969.1  palmitoyltransferase ZDHHC23 isoform X5

  13. XM_054345998.1 → XP_054201973.1  palmitoyltransferase ZDHHC23 isoform X7

  14. XM_054345987.1 → XP_054201962.1  palmitoyltransferase ZDHHC23 isoform X1

    UniProtKB/TrEMBL
    A0A1W2PRJ8

  15. XM_054345997.1 → XP_054201972.1  palmitoyltransferase ZDHHC23 isoform X4

    UniProtKB/TrEMBL
    E9PAP7

  16. XM_054346001.1 → XP_054201976.1  palmitoyltransferase ZDHHC23 isoform X6

    UniProtKB/Swiss-Prot
    D3DN76, Q8IYP9

  17. XM_054345990.1 → XP_054201965.1  palmitoyltransferase ZDHHC23 isoform X2

  18. XM_054346003.1 → XP_054201978.1  palmitoyltransferase ZDHHC23 isoform X8

  19. XM_054346004.1 → XP_054201979.1  palmitoyltransferase ZDHHC23 isoform X9

RNA

  1. XR_008486687.1 RNA Sequence

  2. XR_008486688.1 RNA Sequence

  3. XR_008486686.1 RNA Sequence

  4. XR_008486685.1 RNA Sequence

  5. XR_008486690.1 RNA Sequence

  6. XR_008486683.1 RNA Sequence

  7. XR_008486689.1 RNA Sequence

  8. XR_008486684.1 RNA Sequence

  9. XR_008486692.1 RNA Sequence

  10. XR_008486691.1 RNA Sequence

  11. XR_008486693.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IYP9.3 GenPept UniProtKB/Swiss-Prot:Q8IYP9

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