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C11orf86 chromosome 11 open reading frame 86 [ Homo sapiens (human) ]

Gene ID: 254439, updated on 17-Sep-2024

Summary

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Official Symbol
C11orf86provided by HGNC
Official Full Name
chromosome 11 open reading frame 86provided by HGNC
Primary source
HGNC:HGNC:34442
See related
Ensembl:ENSG00000173237 AllianceGenome:HGNC:34442
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FACI
Expression
Biased expression in duodenum (RPKM 30.9), small intestine (RPKM 29.9) and 1 other tissue See more
Orthologs
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Genomic context

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See C11orf86 in Genome Data Viewer
Location:
11q13.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (66975304..66977009)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (66969804..66971509)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66742775..66744480)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene pyruvate carboxylase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66688620-66689560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66690541-66691041 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:66691815-66692466 Neighboring gene RNA, U7 small nuclear 23 pseudogene Neighboring gene microRNA 3163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5062 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3608 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66743456-66743959 Neighboring gene Sharpr-MPRA regulatory region 11253 Neighboring gene uncharacterized LOC124902849 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66769673-66770332 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:66788895-66790094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66791036-66791536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66791537-66792037 Neighboring gene synaptotagmin 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5064 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66799719-66800558 Neighboring gene microRNA 6860

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FACI Is a Novel CREB-H-Induced Protein That Inhibits Intestinal Lipid Absorption and Reverses Diet-Induced Obesity. Cheng Y, et al. Cell Mol Gastroenterol Hepatol, 2022. PMID 35093589, Free PMC Article
  2. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Psychiatric GWAS Consortium Bipolar Disorder Working Group. Nat Genet, 2011 Sep 18. PMID 21926972, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Clone Names

  • FLJ22675

General protein information

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Preferred Names
uncharacterized protein C11orf86
Names
fasting and CREB-H induced

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136485.3 → NP_001129957.1  uncharacterized protein C11orf86 isoform 2

    See identical proteins and their annotated locations for NP_001129957.1

    Status: VALIDATED

    Source sequence(s)
    AK026328, AP003176
    Consensus CDS
    CCDS44656.1
    UniProtKB/Swiss-Prot
    A6NJI1
    Related
    ENSP00000311479.4, ENST00000308963.4
    Conserved Domains (1) summary
    pfam15464
    Location:1 → 114
    DUF4633; Domain of unknown function (DUF4633)

  2. NM_001353554.2 → NP_001340483.1  uncharacterized protein C11orf86 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK026328, AP003176, HY168701
    Consensus CDS
    CCDS91512.1
    UniProtKB/TrEMBL
    A0A804HHS3
    Related
    ENSP00000506734.1, ENST00000683896.1
    Conserved Domains (1) summary
    pfam15464
    Location:1 → 115
    DUF4633; Domain of unknown function (DUF4633)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    66975304..66977009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    66969804..66971509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NJI1.2 GenPept UniProtKB/Swiss-Prot:A6NJI1

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