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ams1 alpha-mannosidase [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543485, updated on 18-Sep-2024

Summary

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Official Symbol
ams1
Official Full Name
alpha-mannosidase
Primary source
PomBase:SPAC513.05
Locus tag
SPOM_SPAC513.05
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
mns2
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Genomic context

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See ams1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (2914479..2920278)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene M-factor precursor Mfm2 Neighboring gene dihydrodiol dehydrogenase Neighboring gene ncRNA Neighboring gene flavonol reductase/cinnamoyl-CoA reductase family Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cryo-EM structure of fission yeast tetrameric α-mannosidase Ams1. Zhang J, et al. FEBS Open Bio, 2020 Nov. PMID 32981237, Free PMC Article
  2. Characterization of Schizosaccharomyces pombe ER alpha-mannosidase: a reevaluation of the role of the enzyme on ER-associated degradation. Movsichoff F, et al. Mol Biol Cell, 2005 Oct. PMID 16079177, Free PMC Article
  3. Molecular and structural mechanisms of ZZ domain-mediated cargo selection by Nbr1. Wang YY, et al. EMBO J, 2021 Aug 2. PMID 34169534, Free PMC Article
  4. Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription. Heo DH, et al. Cell Rep, 2021 Sep 7. PMID 34496258, Free PMC Article
  5. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mannosyl-oligosaccharide 1,3-alpha-mannosidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mannosyl-oligosaccharide 1,6-alpha-mannosidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mannose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in oligosaccharide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
is_active_in fungal-type vacuole lumen IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
alpha-mannosidase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2914479..2920278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019405.3 → NP_593979.1  alpha-mannosidase [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593979.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9UT61
    Conserved Domains (4) summary
    cd10812
    Location:282 → 538
    GH38N_AMII_ScAms1_like; N-terminal catalytic domain of yeast vacuolar alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38)
    COG0383
    Location:44 → 1077
    AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]
    pfam07748
    Location:664 → 1073
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
    pfam09261
    Location:555 → 634
    Alpha-mann_mid; Alpha mannosidase, middle domain
Nucleotide Protein
Heading Accession and Version

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