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lys12 homoisocitrate dehydrogenase Lys12 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542609, updated on 18-Sep-2024

Summary

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Official Symbol
lys12
Official Full Name
homoisocitrate dehydrogenase Lys12
Primary source
PomBase:SPAC31G5.04
Locus tag
SPOM_SPAC31G5.04
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See lys12 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (2993442..2994929)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene chaperone Rot1 Neighboring gene ncRNA Neighboring gene 40S ribosomal protein uS17 Neighboring gene ribulose phosphate 3-epimerase Neighboring gene ncRNA Neighboring gene protein Rgg8 Neighboring gene tetraspan protein, claudin Dni1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe. Bulfer SL, et al. Proteins, 2012 Feb. PMID 22105743, Free PMC Article
  2. Global fitness profiling of fission yeast deletion strains by barcode sequencing. Han TX, et al. Genome Biol, 2010. PMID 20537132, Free PMC Article
  3. Six new amino acid-auxotrophic markers for targeted gene integration and disruption in fission yeast. Ma Y, et al. Curr Genet, 2007 Aug. PMID 17622533
  4. Expanded Interactome of the Intrinsically Disordered Protein Dss1. Schenstrøm SM, et al. Cell Rep, 2018 Oct 23. PMID 30355493, Free PMC Article
  5. A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response. Ptushkina M, et al. Sci Rep, 2017 Sep 21. PMID 28935859, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystal structure of homoisocitrate dehydrogenase and its active site
    Title: Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables homoisocitrate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lysine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lysine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lysine biosynthetic process via aminoadipic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm HDA PubMed 
is_active_in mitochondrial matrix IC
Inferred by Curator
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
homoisocitrate dehydrogenase Lys12

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2993442..2994929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019430.3 → NP_594004.1  homoisocitrate dehydrogenase Lys12 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594004.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14104
    Conserved Domains (1) summary
    COG0473
    Location:2 → 362
    LeuB; Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version

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