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hsf1 DNA-binding transcription factor Hsf1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541888, updated on 18-Sep-2024

Summary

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Official Symbol
hsf1
Official Full Name
DNA-binding transcription factor Hsf1
Primary source
PomBase:SPAC2E12.02
Locus tag
SPOM_SPAC2E12.02
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
hsf; hstf
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Genomic context

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See hsf1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003424.3 (5059255..5062056)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Set3 complex SANT/Myb domain subunit Snt1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene vacuolar basic amino acid transmembrane transporter Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Heat shock factor is required for growth at normal temperatures in the fission yeast Schizosaccharomyces pombe. Gallo GJ, et al. Mol Cell Biol, 1993 Feb. PMID 8423799, Free PMC Article
  2. Regulation of heat shock factor in Schizosaccharomyces pombe more closely resembles regulation in mammals than in Saccharomyces cerevisiae. Gallo GJ, et al. Mol Cell Biol, 1991 Jan. PMID 1986225, Free PMC Article
  3. Interaction between heat shock transcription factors (HSFs) and divergent binding sequences: binding specificities of yeast HSFs and human HSF1. Sakurai H, et al. J Biol Chem, 2007 May 4. PMID 17347150
  4. hsf1 (+) extends chronological lifespan through Ecl1 family genes in fission yeast. Ohtsuka H, et al. Mol Genet Genomics, 2011 Jan. PMID 21072667
  5. The Schizosaccharomyces pombe Hikeshi/Opi10 protein has similar biochemical functions to its human homolog but acts in different physiological contexts. Oda Y, et al. FEBS Lett, 2014 May 21. PMID 24768994

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We identify the Ssa2-Mas5/Hsp70-Hsp40 chaperone complex as repressor of the heat shock transcription factor Hsf1
    Title: Hsp70-Hsp40 chaperone complex functions in controlling polarized growth by repressing Hsf1-driven heat stress-associated transcription.
  2. Hsf1 extends chronological lifespan of S. pombe when overexpressed. Hsf1 binds to the upstream DNA region of ecl2 (+) after heat shock in S. pombe.
    Title: hsf1 (+) extends chronological lifespan through Ecl1 family genes in fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcription factor Hsf1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    5059255..5062056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020275.3 → NP_594846.1  DNA-binding transcription factor Hsf1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594846.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q02953, Q9USC6
    Conserved Domains (2) summary
    smart00415
    Location:53 → 154
    HSF; heat shock factor
    COG5169
    Location:46 → 331
    HSF1; Heat shock transcription factor [Transcription]
Nucleotide Protein
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