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pub1 HECT-type ubiquitin-protein ligase E3 Pub1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541818, updated on 18-Sep-2024

Summary

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Official Symbol
pub1
Official Full Name
HECT-type ubiquitin-protein ligase E3 Pub1
Primary source
PomBase:SPAC11G7.02
Locus tag
SPOM_SPAC11G7.02
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See pub1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003424.3 (3963066..3966172)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein Mtl2 Neighboring gene ncRNA Neighboring gene isocitrate dehydrogenase (NAD+) subunit 1 Idh1 Neighboring gene ubiquitin-60S ribosomal protein L40 fusion protein Neighboring gene S-malonyltransferase Mct1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3. Wang T, et al. Life Sci Alliance, 2022 May. PMID 35121625, Free PMC Article
  2. The pub1 E3 ubiquitin ligase negatively regulates leucine uptake in response to NH(4)(+) in fission yeast. Karagiannis J, et al. Curr Genet, 1999 Jul. PMID 10467003
  3. The novel HECT-type ubiquitin-protein ligase Pub2p shares partially overlapping function with Pub1p in Schizosaccharomyces pombe. Tamai KK, et al. J Cell Sci, 2002 May 1. PMID 11956316
  4. Tolerance of low pH in Schizosaccharomyces pombe requires a functioning pub1 ubiquitin ligase. Saleki R, et al. Mol Gen Genet, 1997 May 20. PMID 9197411
  5. Urea enhances cell lysis of Schizosaccharomyces pombe ura4 mutants. Nishino K, et al. Biosci Biotechnol Biochem, 2017 Jul. PMID 28345447

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3.
    Title: Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3.
  2. a novel role for Pub1 in endocytosis of Ecm33 and regulation of cell wall integrity in fission yeast [Pub1][Ecm33]
    Title: E3 ubiquitin ligase Pub1 is implicated in endocytosis of a GPI-anchored protein Ecm33 in fission yeast.
  3. Pub1 altered the localization of the uracil transporter Fur4 from the Golgi locus and vacuoles to the plasma membrane.
    Title: Cell Lysis in S. pombe ura4 Mutants Is Suppressed by Loss of Functional Pub1, Which Regulates the Uracil Transporter Fur4.
  4. the TSC-Rheb signaling pathway regulates the localization of amino acid transporters via Pub1 and Any1 in a Tor2-independent manner.
    Title: The fission yeast β-arrestin-like protein Any1 is involved in TSC-Rheb signaling and the regulation of amino acid transporters.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables phospholipid binding ISM
Inferred from Sequence Model
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasm to vacuole targeting by the NVT pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Golgi to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of L-leucine import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of uracil import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus HDA PubMed 
is_active_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
HECT-type ubiquitin-protein ligase E3 Pub1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3963066..3966172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019819.3 → NP_594396.1  HECT-type ubiquitin-protein ligase E3 Pub1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594396.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14454, Q92462
    Conserved Domains (5) summary
    cd08382
    Location:9 → 131
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    smart00456
    Location:346 → 378
    WW; Domain with 2 conserved Trp (W) residues
    COG5021
    Location:1 → 767
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00078
    Location:413 → 765
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:290 → 319
    WW; WW domain
Nucleotide Protein
Heading Accession and Version

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