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rrp4 exosome subunit Rrp4 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541813, updated on 18-Sep-2024

Summary

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Official Symbol
rrp4
Official Full Name
exosome subunit Rrp4
Primary source
PomBase:SPAC2F7.14c
Locus tag
SPOM_SPAC2F7.14C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See rrp4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (560824..562161, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RNA-binding protein Nrd1 Neighboring gene tryptophan-tRNA ligase Wrs1 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The RNA exosome promotes transcription termination of backtracked RNA polymerase II. Lemay JF, et al. Nat Struct Mol Biol, 2014 Oct. PMID 25240800
  2. Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex. Weick EM, et al. Cell, 2018 Jun 14. PMID 29906447, Free PMC Article
  3. The Sm complex is required for the processing of non-coding RNAs by the exosome. Coy S, et al. PLoS One, 2013. PMID 23755256, Free PMC Article
  4. The exoribonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway. Malecki M, et al. EMBO J, 2013 Jul 3. PMID 23503588, Free PMC Article
  5. Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome. Telekawa C, et al. Nucleic Acids Res, 2018 Nov 30. PMID 30321377, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in CUT catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TRAMP-dependent tRNA surveillance pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in U4 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nonfunctional rRNA decay ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear mRNA surveillance TAS
Traceable Author Statement
more info
 PubMed 
involved_in nuclear polyadenylation-dependent mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process, non-stop decay ISO
Inferred from Sequence Orthology
more info
  
involved_in poly(A)-dependent snoRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
part_of exosome (RNase complex) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear exosome (RNase complex) EXP
Inferred from Experiment
more info
 PubMed 
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
exosome subunit Rrp4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    560824..562161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018384.3 → NP_592984.1  exosome subunit Rrp4 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_592984.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q09704
    Conserved Domains (4) summary
    COG1097
    Location:48 → 295
    Rrp4; Exosome complex RNA-binding protein Rrp4, contains S1 and KH domains [Translation, ribosomal structure and biogenesis]
    cd05789
    Location:106 → 197
    S1_Rrp4; S1_Rrp4: Rrp4 S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Rrp4 protein is a subunit of the exosome complex. The exosome plays a central role in 3' to 5' RNA processing and degradation in ...
    pfam14382
    Location:57 → 94
    ECR1_N; Exosome complex exonuclease RRP4 N-terminal region
    pfam15985
    Location:200 → 240
    KH_6; KH domain
Nucleotide Protein
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