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TTLL10 tubulin tyrosine ligase like 10 [ Homo sapiens (human) ]

Gene ID: 254173, updated on 5-Mar-2024

Summary

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Official Symbol
TTLL10provided by HGNC
Official Full Name
tubulin tyrosine ligase like 10provided by HGNC
Primary source
HGNC:HGNC:26693
See related
Ensembl:ENSG00000162571 AllianceGenome:HGNC:26693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTLL5
Summary
Predicted to enable protein-glycine ligase activity, elongating. Predicted to be involved in protein polyglycylation. Predicted to be located in axoneme and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 6.9), lung (RPKM 0.7) and 1 other tissue See more
Orthologs
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Genomic context

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See TTLL10 in Genome Data Viewer
Location:
1p36.33
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1173880..1197936)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (602477..626317)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1109260..1133316)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903818 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1106186-1106753 Neighboring gene microRNA 200a Neighboring gene microRNA 429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 43 Neighboring gene TTLL10 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1110977-1111495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1114551-1115050 Neighboring gene MPRA-validated peak5 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 44 Neighboring gene MPRA-validated peak6 silencer Neighboring gene TNF receptor superfamily member 18 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1143552-1144431 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 47 Neighboring gene TNF receptor superfamily member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TTLL10 is a protein polyglycylase that can modify nucleosome assembly protein 1. Ikegami K, et al. FEBS Lett, 2008 Apr 2. PMID 18331838, Free PMC Article
  2. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Rogowski K, et al. Cell, 2009 Jun 12. PMID 19524510
  3. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Janke C, et al. Science, 2005 Jun 17. PMID 15890843
  4. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348
  5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ36119, FLJ42131

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
NOT enables protein-glycine ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-glycine ligase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
NOT involved_in protein polyglycylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
inactive polyglycylase TTLL10
Names
tubulin tyrosine ligase-like family, member 10
tubulin tyrosine ligase-like family, member 5
tubulin--tyrosine ligase-like protein 10
NP_001123517.1
NP_001358578.1
NP_694986.2
XP_005244795.1
XP_016856395.2
XP_016856396.2
XP_016856397.2
XP_016856398.2
XP_016856399.2
XP_016856401.1
XP_047272797.1
XP_047272798.1
XP_047272799.1
XP_047272826.1
XP_047272838.1
XP_054191731.1
XP_054191732.1
XP_054191733.1
XP_054191734.1
XP_054191735.1
XP_054191736.1
XP_054191737.1
XP_054191738.1
XP_054191739.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130045.2 → NP_001123517.1  inactive polyglycylase TTLL10 isoform 1

    See identical proteins and their annotated locations for NP_001123517.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AL162741, AL390719
    Consensus CDS
    CCDS44036.1
    UniProtKB/Swiss-Prot
    B1AMF6, Q5T2W4, Q5T2W5, Q6ZVT0, Q8N9X2
    Related
    ENSP00000368591.1, ENST00000379289.6
    Conserved Domains (3) summary
    PHA03247
    Location:9 → 99
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:568 → 673
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl17255
    Location:284 → 548
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  2. NM_001371649.1 → NP_001358578.1  inactive polyglycylase TTLL10 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AL162741, AL390719
    Consensus CDS
    CCDS44036.1
    UniProtKB/Swiss-Prot
    B1AMF6, Q5T2W4, Q5T2W5, Q6ZVT0, Q8N9X2
    Related
    ENSP00000368592.1, ENST00000379290.6
    Conserved Domains (3) summary
    PHA03247
    Location:9 → 99
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:568 → 673
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl17255
    Location:284 → 548
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  3. NM_153254.3 → NP_694986.2  inactive polyglycylase TTLL10 isoform 2

    See identical proteins and their annotated locations for NP_694986.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the 5' and 3' termini, compared to variant 3. These differences cause translation initiation from a downstream ATG and an isoform (2) with shorter N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AK093438, AL390719, BC126152, BX117374
    Consensus CDS
    CCDS8.1
    UniProtKB/Swiss-Prot
    Q6ZVT0
    Related
    ENSP00000368590.3, ENST00000379288.3
    Conserved Domains (1) summary
    cl17255
    Location:211 → 373
    ATP-grasp_4; ATP-grasp domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    1173880..1197936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416841.1 → XP_047272797.1  inactive polyglycylase TTLL10 isoform X1

  2. XM_017000906.2 → XP_016856395.2  inactive polyglycylase TTLL10 isoform X2

  3. XM_047416842.1 → XP_047272798.1  inactive polyglycylase TTLL10 isoform X3

  4. XM_047416843.1 → XP_047272799.1  inactive polyglycylase TTLL10 isoform X1

  5. XM_047416870.1 → XP_047272826.1  inactive polyglycylase TTLL10 isoform X8

    UniProtKB/Swiss-Prot
    B1AMF6, Q5T2W4, Q5T2W5, Q6ZVT0, Q8N9X2

  6. XM_017000909.2 → XP_016856398.2  inactive polyglycylase TTLL10 isoform X6

  7. XM_017000910.3 → XP_016856399.2  inactive polyglycylase TTLL10 isoform X7

  8. XM_017000908.2 → XP_016856397.2  inactive polyglycylase TTLL10 isoform X5

  9. XM_017000907.2 → XP_016856396.2  inactive polyglycylase TTLL10 isoform X4

  10. XM_047416882.1 → XP_047272838.1  inactive polyglycylase TTLL10 isoform X9

  11. XM_017000912.2 → XP_016856401.1  inactive polyglycylase TTLL10 isoform X8

    UniProtKB/Swiss-Prot
    B1AMF6, Q5T2W4, Q5T2W5, Q6ZVT0, Q8N9X2
    Conserved Domains (3) summary
    PHA03247
    Location:9 → 99
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:568 → 673
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl17255
    Location:284 → 548
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  12. XM_005244738.2 → XP_005244795.1  inactive polyglycylase TTLL10 isoform X10

    UniProtKB/Swiss-Prot
    Q6ZVT0
    Conserved Domains (1) summary
    cl17255
    Location:211 → 475
    ATP-grasp_4; ATP-grasp domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    602477..626317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335757.1 → XP_054191732.1  inactive polyglycylase TTLL10 isoform X1

  2. XM_054335762.1 → XP_054191737.1  inactive polyglycylase TTLL10 isoform X8

  3. XM_054335756.1 → XP_054191731.1  inactive polyglycylase TTLL10 isoform X11

  4. XM_054335760.1 → XP_054191735.1  inactive polyglycylase TTLL10 isoform X14

  5. XM_054335761.1 → XP_054191736.1  inactive polyglycylase TTLL10 isoform X15

  6. XM_054335759.1 → XP_054191734.1  inactive polyglycylase TTLL10 isoform X13

  7. XM_054335758.1 → XP_054191733.1  inactive polyglycylase TTLL10 isoform X12

  8. XM_054335763.1 → XP_054191738.1  inactive polyglycylase TTLL10 isoform X16

  9. XM_054335764.1 → XP_054191739.1  inactive polyglycylase TTLL10 isoform X10

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZVT0.2 GenPept UniProtKB/Swiss-Prot:Q6ZVT0

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