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tsn1 translin [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541714, updated on 18-Sep-2024

Summary

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Official Symbol
tsn1
Official Full Name
translin
Primary source
PomBase:SPAC30.03c
Locus tag
SPOM_SPAC30.03C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
mug90; tsn
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Genomic context

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See tsn1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003424.3 (4394376..4395629, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Sec7 domain-containing protein sec72 Neighboring gene ncRNA Neighboring gene elongator complex-associated protein Kti2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene vacuolar phytochelatin and glutathione S-conjugate ABC family transmembrane transporter Abc4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mapping of interaction sites of the Schizosaccharomyces pombe protein Translin with nucleic acids and proteins: a combined molecular genetics and bioinformatics study. Eliahoo E, et al. Nucleic Acids Res, 2010 May. PMID 20081200, Free PMC Article
  2. Functional characterisation of the Schizosaccharomyces pombe homologue of the leukaemia-associated translocation breakpoint binding protein translin and its binding partner, TRAX. Jaendling A, et al. Biochim Biophys Acta, 2008 Feb. PMID 18062930
  3. Cloning and characterization of the Schizosaccharomyces pombe homologs of the human protein Translin and the Translin-associated protein TRAX. Laufman O, et al. Nucleic Acids Res, 2005. PMID 16043634, Free PMC Article
  4. Biochemical characterization of clinically relevant mutations of human Translin. Pillai V, et al. Mol Cell Biochem, 2023 Apr. PMID 36098897
  5. Identification of proteins that form specific complexes with the highly conserved protein Translin in Schizosaccharomyces pombe. Eliahoo E, et al. Biochim Biophys Acta, 2014 Apr. PMID 24382491

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Translin and Trax differentially regulate telomere-associated transcript homeostasis.
    Title: Translin and Trax differentially regulate telomere-associated transcript homeostasis.
  2. Translin binds the pre-mRNA-splicing factor srp1 and vip1, a protein conserved in fungi.
    Title: Identification of proteins that form specific complexes with the highly conserved protein Translin in Schizosaccharomyces pombe.
  3. Bioinformatics combined with yeast two-hybrid assays and proteomic analyses of deletion variants, identified at the top of the spTranslin structure a region required for interaction with spTRAX, and for spTranslin dimerization.
    Title: Mapping of interaction sites of the Schizosaccharomyces pombe protein Translin with nucleic acids and proteins: a combined molecular genetics and bioinformatics study.
  4. Translin is a non-essential, octameric protein that selectively binds ssDNA microsatellite repeats & corresponding RNA sequences but not dsDNA. Its much higher affinity for RNA repeats suggests that it's involved in RNA metabolism-related functions. [tsn]
    Title: Cloning and characterization of the Schizosaccharomyces pombe homologs of the human protein Translin and the Translin-associated protein TRAX.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables GU repeat RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to RNA nuclease activity TAS
Traceable Author Statement
more info
 PubMed 
enables microsatellite binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded telomeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA processing TAS
Traceable Author Statement
more info
 PubMed 
NOT involved_in double-strand break repair via homologous recombination TAS
Traceable Author Statement
more info
 PubMed 
NOT involved_in double-strand break repair via nonhomologous end joining TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
translin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    4394376..4395629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019986.4 → NP_594557.2  translin [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594557.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9P7V3
    Conserved Domains (1) summary
    cd14819
    Location:9 → 218
    Translin; Translin, also known as TB-RBP (testis brain RNA-binding protein)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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