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brc1 BRCT domain protein Brc1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541071, updated on 10-Oct-2024

Summary

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Official Symbol
brc1
Official Full Name
BRCT domain protein Brc1
Primary source
PomBase:SPBC582.05c
Locus tag
SPOM_SPBC582.05C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See brc1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003423.3 (426160..428919, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein dsh1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene horsetail movement protein Hrs1/Mcp6 Neighboring gene ncRNA Neighboring gene 19S proteasome regulatory subunit Rpn7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. γH2A-binding protein Brc1 affects centromere function in fission yeast. Lee SY, et al. Mol Cell Biol, 2013 Apr. PMID 23358415, Free PMC Article
  2. Rad18 is required for DNA repair and checkpoint responses in fission yeast. Verkade HM, et al. Mol Biol Cell, 1999 Sep. PMID 10473635, Free PMC Article
  3. Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and γH2A To Maintain Genome Stability during S Phase. Reubens MC, et al. Mol Cell Biol, 2017 Nov 15. PMID 28784724, Free PMC Article
  4. gammaH2A binds Brc1 to maintain genome integrity during S-phase. Williams JS, et al. EMBO J, 2010 Mar 17. PMID 20094029, Free PMC Article
  5. Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA. Zabrady K, et al. Nucleic Acids Res, 2016 Feb 18. PMID 26446992, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Brc1 is required for the accumulation of the Smc5-Smc6 genome stability complex in foci during replication stress and for activation of the intrinsic SUMO ligase activity of the complex by collapsed replication forks.
    Title: Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress.
  2. Results provide evidence that Brc1 provides scaffolding functions linking gammaH2A, Rhp18, and Smc5/6 complex at damaged replication forks.
    Title: Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and γH2A To Maintain Genome Stability during S Phase.
  3. Brc1-mediated stabilization of stalled replication forks.
    Title: γH2A-binding protein Brc1 affects centromere function in fission yeast.
  4. Cells lacking Brc1 undergo an origin recognition complex-dependent rescue of replication stress.
    Title: Brc1-dependent recovery from replication stress.
  5. Brc1 functions to promote recombination through a novel postreplication repair pathway and the structure-specific nucleases Slx1 and Mus81.
    Title: Brc1-mediated DNA repair and damage tolerance.
  6. A particular allele of smc6 (smc6-74) is suppressed by overexpression of Brc1, a six-BRCT domain protein that is required for DNA repair during S-phase.
    Title: Brc1-mediated rescue of Smc5/6 deficiency: requirement for multiple nucleases and a novel Rad18 function.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables chromatin-protein adaptor activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA double-strand break attachment to nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair EXP
Inferred from Experiment
more info
 PubMed 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul8-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome, subtelomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus EXP
Inferred from Experiment
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in rDNA heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
BRCT domain protein Brc1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    426160..428919 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001431010.1 → NP_001417957.1  BRCT domain protein Brc1 [Schizosaccharomyces pombe]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAN2L3Z3
Nucleotide Protein
Heading Accession and Version

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Research Materials