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sec61 translocon alpha subunit Sec61 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541037, updated on 18-Sep-2024

Summary

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Official Symbol
sec61
Official Full Name
translocon alpha subunit Sec61
Primary source
PomBase:SPBC354.02c
Locus tag
SPOM_SPBC354.02C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See sec61 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003423.3 (544751..547014, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tail anchored plasma membrane protein Uvi15 Neighboring gene protein Cut12 Neighboring gene ncRNA Neighboring gene GTP-binding protein Gtp1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Set1C complex WD repeat protein Swd3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning of SEC61 homologues from Schizosaccharomyces pombe and Yarrowia lipolytica reveals the extent of functional conservation within this core component of the ER translocation machinery. Broughton J, et al. J Cell Sci, 1997 Nov. PMID 9427389
  2. Calnexin is essential for survival under nitrogen starvation and stationary phase in Schizosaccharomyces pombe. Núñez A, et al. PLoS One, 2015. PMID 25803873, Free PMC Article
  3. An evolutionarily conserved fission yeast protein, Ned1, implicated in normal nuclear morphology and chromosome stability, interacts with Dis3, Pim1/RCC1 and an essential nucleoporin. Tange Y, et al. J Cell Sci, 2002 Nov 15. PMID 12376568
  4. High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library. Varberg JM, et al. G3 (Bethesda), 2020 Dec 3. PMID 33109728, Free PMC Article
  5. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signal sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-translational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into ER membrane IC
Inferred by Curator
more info
  
Component Evidence Code Pubs
part_of Sec61 translocon complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in fungal-type vacuole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
translocon alpha subunit Sec61

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    544751..547014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021132.3 → NP_595226.1  translocon alpha subunit Sec61 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595226.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P79088, Q9UU67
    Conserved Domains (3) summary
    PTZ00219
    Location:5 → 473
    PTZ00219; Sec61 alpha subunit; Provisional
    pfam00344
    Location:76 → 458
    SecY; SecY translocase
    pfam10559
    Location:41 → 74
    Plug_translocon; Plug domain of Sec61p
Nucleotide Protein
Heading Accession and Version

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