U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

wpl1 WAPL family protein [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540860, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
wpl1
Official Full Name
WAPL family protein
Primary source
PomBase:SPBC428.17c
Locus tag
SPOM_SPBC428.17C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See wpl1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003423.3 (474574..476728, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Obg-like ATPase Neighboring gene 1-acylglycerol-3-phosphate acyltransferase Neighboring gene ncRNA Neighboring gene Rheb GTPase Rhb1 Neighboring gene ncRNA Neighboring gene DNA replication licensing factor Cdt1 Neighboring gene U3 snoRNP protein Utp15

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Rec8 Cohesin-mediated Axis-loop chromatin architecture is required for meiotic recombination. Sakuno T, et al. Nucleic Acids Res, 2022 Apr 22. PMID 35333350, Free PMC Article
  2. Cell-cycle regulation of cohesin stability along fission yeast chromosomes. Bernard P, et al. EMBO J, 2008 Jan 9. PMID 18079700, Free PMC Article
  3. Psm3 acetylation on conserved lysine residues is dispensable for viability in fission yeast but contributes to Eso1-mediated sister chromatid cohesion by antagonizing Wpl1. Feytout A, et al. Mol Cell Biol, 2011 Apr. PMID 21300781, Free PMC Article
  4. DNA Topoisomerase II modulates acetyl-regulation of cohesin-mediated chromosome dynamics. Lin SJ, et al. Curr Genet, 2017 Oct. PMID 28382430, Free PMC Article
  5. Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module. Goto Y, et al. Curr Biol, 2017 Apr 3. PMID 28343969

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Psm3 acetylation contributes to Eso1 counteracting of Wpl1 to secure stable cohesin interaction with postreplicative chromosomes
    Title: Psm3 acetylation on conserved lysine residues is dispensable for viability in fission yeast but contributes to Eso1-mediated sister chromatid cohesion by antagonizing Wpl1.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP hydrolysis activity IC
Inferred by Curator
more info
  
enables ATP-dependent protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cohesin unloader activity EXP
Inferred from Experiment
more info
 PubMed 
enables cohesin unloader activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid cohesion EXP
Inferred from Experiment
more info
 PubMed 
involved_in mitotic sister chromatid cohesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Wpl/Pds5 cohesin loading/unloading complex EXP
Inferred from Experiment
more info
 PubMed 
is_active_in nuclear chromosome IC
Inferred by Curator
more info
 PubMed 
is_active_in nucleus HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
WAPL family protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    474574..476728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021102.3 → NP_595195.1  WAPL family protein [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595195.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94364, Q9USF1
    Conserved Domains (1) summary
    pfam07814
    Location:161 → 467
    WAPL; Wings apart-like protein regulation of heterochromatin
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous