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top2 DNA topoisomerase II [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540541, updated on 22-Jun-2024

Summary

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Gene symbol
top2
Gene description
DNA topoisomerase II
Locus tag
SPOM_SPBC1A4.03C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
ptr11
Old locus tag
SPBC1A4.03c
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Genomic context

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See top2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (1976161..1981267, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene anaphase-promoting complex substrate recognition subunit Apc10 Neighboring gene ncRNA Neighboring gene 3-isopropylmalate dehydrogenase Leu1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A non-canonical function of topoisomerase II in disentangling dysfunctional telomeres. Germe T, et al. EMBO J, 2009 Sep 16. PMID 19680223, Free PMC Article
  2. Mitotic spindle pulls but fails to separate chromosomes in type II DNA topoisomerase mutants: uncoordinated mitosis. Uemura T, et al. EMBO J, 1986 May. PMID 15957215, Free PMC Article
  3. DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe. Uemura T, et al. Cell, 1987 Sep 11. PMID 3040264
  4. The nucleotide sequence of the fission yeast DNA topoisomerase II gene: structural and functional relationships to other DNA topoisomerases. Uemura T, et al. EMBO J, 1986 Sep. PMID 3023070, Free PMC Article
  5. Functional dissection of the phosphorylated termini of fission yeast DNA topoisomerase II. Shiozaki K, et al. J Cell Biol, 1992 Dec. PMID 1332977, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rrp2 possesses SUMO-binding ability and prevents excessive Top2 degradation by competing against the SUMO-targeted ubiquitin ligase (STUbL) for SUMO chain binding and by displacing SUMOylated Top2 from DNA.
    Title: SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage.
  2. DNA topoisomerase 2 mutant allele mildly delays the mitotic progression and activates the checkpoint protein kinase Chk1 in fission yeast Schizosaccharomyces pombe.
    Title: DNA topoisomerase 2 mutant allele mildly delays the mitotic progression and activates the checkpoint protein kinase Chk1 in fission yeast Schizosaccharomyces pombe.
  3. topoisomerase II has a role in disentangling dysfunctional telomeres
    Title: A non-canonical function of topoisomerase II in disentangling dysfunctional telomeres.
  4. Schizosaccharomyces pombe Rad32(Mre11) nuclease activity is involved in the removal of both Top2 from 5' DNA ends as well as Top1 from 3' ends in vivo and a ctp1(CtIP) deletion is defective for Top2 removal but overproficient for Top1 removal.
    Title: Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IC
Inferred by Curator
more info
 PubMed 
enables ATP hydrolysis activity IC
Inferred by Curator
more info
  
enables DNA binding ISM
Inferred from Sequence Model
more info
  
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA topological change IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in DNA topological change IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in resolution of meiotic recombination intermediates IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in resolution of meiotic recombination intermediates IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome, centromeric core domain IDA
Inferred from Direct Assay
more info
 PubMed 
part_of euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear chromosome NAS
Non-traceable Author Statement
more info
  
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA topoisomerase II

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    1976161..1981267 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021708.3 → NP_595805.1  DNA topoisomerase II [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595805.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74336, P08096
    Conserved Domains (7) summary
    cd03365
    Location:499 → 617
    TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
    cd00187
    Location:741 → 1198
    TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
    cd03481
    Location:311 → 462
    TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
    PTZ00108
    Location:77 → 1468
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam02518
    Location:125 → 219
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
    pfam08070
    Location:1320 → 1448
    DTHCT; DTHCT (NUC029) region
    pfam16898
    Location:615 → 741
    TOPRIM_C; C-terminal associated domain of TOPRIM
Nucleotide Protein
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