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doa10 ubiquitin ligase Doa10 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539855, updated on 18-Sep-2024

Summary

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Official Symbol
doa10
Official Full Name
ubiquitin ligase Doa10
Primary source
PomBase:SPBC14F5.07
Locus tag
SPOM_SPBC14F5.07
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
ssm4
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Genomic context

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See doa10 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003423.3 (4167479..4171911)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Fe-sulfur ATPase Rli1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mediator complex subunit Med7 Neighboring gene adenylosuccinate lyase Ade8 Neighboring gene ubiquitin-protein ligase E3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A ubiquitin-proteasome pathway degrades the inner nuclear membrane protein Bqt4 to maintain nuclear membrane homeostasis. Le TK, et al. J Cell Sci, 2023 Oct 1. PMID 37694715
  2. DNA binding by the MATα2 transcription factor controls its access to alternative ubiquitin-modification pathways. Hickey CM, et al. Mol Biol Cell, 2018 Mar 1. PMID 29298839, Free PMC Article
  3. Nuclear protein quality is regulated by the ubiquitin-proteasome system through the activity of Ubc4 and San1 in fission yeast. Matsuo Y, et al. J Biol Chem, 2011 Apr 15. PMID 21324894, Free PMC Article
  4. Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species. Beltrao P, et al. PLoS Biol, 2009 Jun 16. PMID 19547744, Free PMC Article
  5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inner nuclear membrane-associated protein degradation pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear inner membrane EXP
Inferred from Experiment
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin ligase Doa10

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    4167479..4171911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022659.3 → NP_596733.1  ubiquitin ligase Doa10 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596733.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O60103
    Conserved Domains (2) summary
    smart00744
    Location:7 → 55
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
    COG5183
    Location:1 → 1239
    SSM4; E3 ubiquitin-protein ligase DOA10 [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version

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