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ufd1 Hrd1 ubiquitin ligase complex subunit Ufd1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539623, updated on 18-Sep-2024

Summary

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Official Symbol
ufd1
Official Full Name
Hrd1 ubiquitin ligase complex subunit Ufd1
Primary source
PomBase:SPBC16A3.09c
Locus tag
SPOM_SPBC16A3.09C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See ufd1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003423.3 (4282032..4283614)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mitotic cohesin N-acetyltransferase/DNA polymerase eta Eso1 fusion protein Neighboring gene MBOAT family O-acyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein stm1 Neighboring gene protein nrm1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Single site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing. Marinova IN, et al. PLoS One, 2015. PMID 25658828, Free PMC Article
  2. SUMO-targeted ubiquitin ligase activity can either suppress or promote genome instability, depending on the nature of the DNA lesion. Nie M, et al. PLoS Genet, 2017 May. PMID 28475613, Free PMC Article
  3. Concerted action of the ubiquitin-fusion degradation protein 1 (Ufd1) and Sumo-targeted ubiquitin ligases (STUbLs) in the DNA-damage response. Køhler JB, et al. PLoS One, 2013. PMID 24265825, Free PMC Article
  4. Functional Crosstalk between the PP2A and SUMO Pathways Revealed by Analysis of STUbL Suppressor, razor 1-1. Nie M, et al. PLoS Genet, 2016 Jul. PMID 27398807, Free PMC Article
  5. Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast. Burr R, et al. J Biol Chem, 2017 Sep 29. PMID 28821619, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that cdc48 cofactor ufd1 is required for SREBP1/2 cleavage/activation but does not interact with cdc48-rbd2 complex; cdc48-ufd1 is instead required at step prior to rbd2 function, during Golgi localization of dsc1-E3 ligase. (cdc48 = AAA family ATPase cdc48; ufd1 = cdc48-ufd1-npl4 complex component ufd1; dsc1-E3 ligase = ubiquitin-protein ligase E3; SREBP1/2 = sterol regulatory element binding proteins 1/2)
    Title: Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast.
  2. a new signaling mechanism involving dual recruitment by SUMO and ubiquitin for Cdc48-Ufd1-Npl4 functions in maintaining genome stability.
    Title: Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables SUMO binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SREBP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Hrd1p ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of RQC complex ISO
Inferred from Sequence Orthology
more info
  
part_of VCP-NPL4-UFD1 AAA ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
Hrd1 ubiquitin ligase complex subunit Ufd1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    4282032..4283614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023801.3 → NP_596780.1  Hrd1 ubiquitin ligase complex subunit Ufd1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596780.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13409, O42915, O60193, Q1MVD5
    Conserved Domains (2) summary
    COG5140
    Location:1 → 341
    UFD1; Ubiquitin fusion-degradation protein [Posttranslational modification, protein turnover, chaperones]
    pfam03152
    Location:32 → 208
    UFD1; Ubiquitin fusion degradation protein UFD1
Nucleotide Protein
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