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gtr2 RagC/D GTPase Gtr2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539088, updated on 18-Sep-2024

Summary

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Official Symbol
gtr2
Official Full Name
RagC/D GTPase Gtr2
Primary source
PomBase:SPCC777.05
Locus tag
SPOM_SPCC777.05
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See gtr2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003421.2 (1605093..1606539)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene cysteine desulfurase nifs family protein Neighboring gene ncRNA Neighboring gene amino acid transporter Dip5 Neighboring gene hydrolase Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TORC1 signaling is governed by two negative regulators in fission yeast. Ma N, et al. Genetics, 2013 Oct. PMID 23934889, Free PMC Article
  2. The Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids in fission yeast. Valbuena N, et al. J Cell Sci, 2012 Apr 15. PMID 22344254, Free PMC Article
  3. The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission Yeast. Ma N, et al. PLoS One, 2016. PMID 27227887, Free PMC Article
  4. Isp7 is a novel regulator of amino acid uptake in the TOR signaling pathway. Laor D, et al. Mol Cell Biol, 2014 Mar. PMID 24344203, Free PMC Article
  5. Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases. Chia KH, et al. Elife, 2017 Dec 4. PMID 29199950, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids.
    Title: The Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids in fission yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell cycle switching, mitotic to meiotic cell cycle EXP
Inferred from Experiment
more info
 PubMed 
involved_in positive regulation of TORC1 signaling EXP
Inferred from Experiment
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Gtr1-Gtr2 GTPase complex EXP
Inferred from Experiment
more info
 PubMed 
part_of Gtr1-Gtr2 GTPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Gtr1-Gtr2 GTPase complex IGI
Inferred from Genetic Interaction
more info
 PubMed 
part_of Gtr1-Gtr2 GTPase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in fungal-type vacuole membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RagC/D GTPase Gtr2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1605093..1606539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023241.3 → NP_588251.1  RagC/D GTPase Gtr2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588251.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74544
    Conserved Domains (2) summary
    cd11385
    Location:5 → 177
    RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D
    COG1100
    Location:1 → 155
    Gem1; GTPase SAR1 family domain [General function prediction only]
Nucleotide Protein
Heading Accession and Version

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