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ubp12 CSN-associated deubiquitinating enzyme Ubp12 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2538990, updated on 18-Sep-2024

Summary

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Official Symbol
ubp12
Official Full Name
CSN-associated deubiquitinating enzyme Ubp12
Primary source
PomBase:SPCC1494.05c
Locus tag
SPOM_SPCC1494.05C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See ubp12 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (2328869..2332471, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene armadillo repeat-containing zfs1 target protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NADP-dependent prephenate dehydrogenase Tyr1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase Dbp9 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p. Zhou C, et al. Mol Cell, 2003 Apr. PMID 12718879
  2. CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability. Wee S, et al. Nat Cell Biol, 2005 Apr. PMID 15793566
  3. Orderly progression through S-phase requires dynamic ubiquitylation and deubiquitylation of PCNA. Álvarez V, et al. Sci Rep, 2016 May 6. PMID 27151298, Free PMC Article
  4. A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity. Kouranti I, et al. PLoS Biol, 2010 Sep 7. PMID 20838651, Free PMC Article
  5. Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Stewart EV, et al. Mol Cell, 2011 Apr 22. PMID 21504829, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal-dependent deubiquitinase activity HDA PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm HDA PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
CSN-associated deubiquitinating enzyme Ubp12

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    2328869..2332471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023518.3 → NP_588530.1  CSN-associated deubiquitinating enzyme Ubp12 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588530.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O60079
    Conserved Domains (5) summary
    smart00695
    Location:69 → 155
    DUSP; Domain in ubiquitin-specific proteases
    COG5560
    Location:33 → 978
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:825 → 975
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:312 → 513
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam14533
    Location:519 → 648
    USP7_C2; Ubiquitin-specific protease C-terminal
Nucleotide Protein
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