Bdkrb2 bradykinin receptor B2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bdkrb2provided by RGD
Official Full Name: bradykinin receptor B2provided by RGD
Primary source: RGD:2201
See related: EnsemblRapid:ENSRNOG00000047300 AllianceGenome:RGD:2201
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: B2BKR; B2BRA
Summary: Enables beta-2 adrenergic receptor binding activity and bradykinin receptor activity. Involved in several processes, including acute inflammatory response to antigenic stimulus; cellular response to hypoxia; and maintenance of blood-brain barrier. Predicted to be located in Golgi apparatus and endosome. Predicted to be active in plasma membrane. Used to study several diseases, including asthma; pancreatitis; pleurisy; portal hypertension; and pulmonary hypertension. Biomarker of high grade glioma; hypertension; myocardial infarction; and sciatic neuropathy. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; hypertension; and rhinitis. Orthologous to human BDKRB2 (bradykinin receptor B2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 44.5), Uterus (RPKM 44.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (130237055..130267205)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (124472317..124502497)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (129399468..129429676)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myocardial angiogenesis induced by exercise training involves a regulatory mechanism mediated by kinin receptors.
Title: Myocardial angiogenesis induced by exercise training involves a regulatory mechanism mediated by kinin receptors.
This is the first study that provides evidence supporting the existence of bradykinin receptor B2 - thromboxane TP receptors heteromerization fingerprints in primary cultured vascular smooth muscle cell.
Title: Heteromerization fingerprints between bradykinin B2 and thromboxane TP receptors in native cells.
High bradykinin receptor B2 expression is associated with spinal cord ischemia-reperfusion injury.
Title: The expression of bradykinin and its receptors in spinal cord ischemia-reperfusion injury rat model.
Mas receptor antagonist abolished relaxation while bradykinin receptor antagonist only slightly reduced it, suggesting that bradykinin-induced vasorelaxation is regulated also by other mechanisms than the classical BR1/BR2 pathway.
Title: Bradykinin -induced vasodilatation: Role of age, ACE1-inhibitory peptide, mas- and bradykinin receptors.
Findings suggest that bradykinin 1 receptor and bradykinin 2 receptor have detrimental and beneficial effects, respectively in diabetic cerebral ischaemia.
Title: Opposite roles of bradykinin B1 and B2 receptors during cerebral ischaemia-reperfusion injury in experimental diabetic rats.
Up-regulation of the kinin B2 receptor pathway modulates the TGF-beta/Smad signaling cascade to reduce renal fibrosis induced by albumin.
Title: Up-regulation of the kinin B2 receptor pathway modulates the TGF-β/Smad signaling cascade to reduce renal fibrosis induced by albumin.
These results indicate that B2R couples with P2Y2R and that these G-protein-coupled receptors act together to fine-tune cellular responsiveness.
Title: Close association of B2 bradykinin receptors with P2Y2 ATP receptors.
B2R signaling may regulate monocyte/macrophage infiltration and c-Jun signals in the irradiated heart. Although eNOS is a main target for kinins, the B2R may not regulate eNOS phosphorylation in response to radiation.
Title: Role of the bradykinin B2 receptor in a rat model of local heart irradiation.
bradykinin receptor B1 may participate in apoptotic cell death signalling, and bradykinin receptor B2 may be involved in necrotic cell death
Title: Differential bradykinin B1 and B2 receptor regulation in cell death induced by hepatic ischaemia/reperfusion injury.
Data indicate that ANO1 channels form signaling complexes with IP3 receptor (IP3R1) and GPCRs bradykinin receptor 2 (B2R) and protease-activated receptor 2 (PAR-2).
Title: Activation of the Cl- channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptor.

Submit: New GeneRIF Correction See all GeneRIFs (58)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC150944P1 (e-PCR)
- UniSTS:271125

RH94464 (e-PCR)
- UniSTS:119712

PMC126639P3 (e-PCR)
- UniSTS:270552

L27595 (e-PCR)
- UniSTS:124891

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-2 adrenergic receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables bradykinin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables bradykinin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables bradykinin receptor activity	IEA Inferred from Electronic Annotation more info
enables bradykinin receptor activity	ISO Inferred from Sequence Orthology more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables type 1 angiotensin receptor binding	IEA Inferred from Electronic Annotation more info
enables type 1 angiotensin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in acute inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in arachidonate secretion	IEA Inferred from Electronic Annotation more info
involved_in arachidonate secretion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator	IEA Inferred from Electronic Annotation more info
acts_upstream_of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in maintenance of blood-brain barrier	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuromuscular synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in response to salt stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to salt stress	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in urinary bladder smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in vasodilation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasodilation	ISO Inferred from Sequence Orthology more info
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: B2 bradykinin receptor

Names: B2R; BK-2 receptor; bradykinin receptor, beta 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270713.2 → NP_001257642.1 B2 bradykinin receptor isoform 1

See identical proteins and their annotated locations for NP_001257642.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000006, M59967

UniProtKB/Swiss-Prot

P25023

UniProtKB/TrEMBL

A6KBC5, G3V942

Related

ENSRNOP00000064990.1, ENSRNOT00000074621.4

Conserved Domains (1) summary

cd15381
Location:66 → 350

7tmA_BK-2; bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_173100.3 → NP_775123.2 B2 bradykinin receptor isoform 2

See identical proteins and their annotated locations for NP_775123.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an internal exon in the 5' region, compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

P25023

UniProtKB/TrEMBL

A0A0H2UI29, A6KBC4

Related

ENSRNOP00000064715.2, ENSRNOT00000071735.4

Conserved Domains (1) summary

cd15381
Location:60 → 344

7tmA_BK-2; bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

130237055..130267205

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111801.2 → XP_038967729.1 B2 bradykinin receptor isoform X2

UniProtKB/Swiss-Prot

P25023

UniProtKB/TrEMBL

A0A0H2UI29, A6KBC4

Conserved Domains (1) summary

cd15381
Location:60 → 344

7tmA_BK-2; bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_063261560.1 → XP_063117630.1 B2 bradykinin receptor isoform X1

UniProtKB/TrEMBL

A6KBC5, G3V942
XM_039111800.2 → XP_038967728.1 B2 bradykinin receptor isoform X1

UniProtKB/Swiss-Prot

P25023

UniProtKB/TrEMBL

A6KBC5, G3V942

Conserved Domains (1) summary

cd15381
Location:66 → 350

7tmA_BK-2; bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_063261559.1 → XP_063117629.1 B2 bradykinin receptor isoform X1

UniProtKB/TrEMBL

A6KBC5, G3V942