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Htr1b 5-hydroxytryptamine receptor 1B [ Rattus norvegicus (Norway rat) ]

Gene ID: 25075, updated on 2-Nov-2024

Summary

Official Symbol
Htr1bprovided by RGD
Official Full Name
5-hydroxytryptamine receptor 1Bprovided by RGD
Primary source
RGD:2846
See related
EnsemblRapid:ENSRNOG00000013042 AllianceGenome:RGD:2846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables G protein-coupled serotonin receptor activity; heterocyclic compound binding activity; and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in several processes, including drinking behavior; modulation of chemical synaptic transmission; and regulation of amine transport. Is active in calyx of Held. Used to study anxiety disorder. Biomarker of hypertension; ischemia; and obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and substance abuse (multiple). Orthologous to human HTR1B (5-hydroxytryptamine receptor 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 23.4), Muscle (RPKM 6.9) and 5 other tissues See more
Orthologs
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Genomic context

See Htr1b in Genome Data Viewer
Location:
8q31
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (91395405..91414815, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (82513572..82534670, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (89113984..89130830, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480212 Neighboring gene myosin VI Neighboring gene interphotoreceptor matrix proteoglycan 1 Neighboring gene uncharacterized LOC108351750 Neighboring gene uncharacterized LOC134480079

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in G protein-coupled receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within bone remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to alkaloid ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to alkaloid ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to temperature stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to xenobiotic stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in drinking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gamma-aminobutyric acid secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of serotonin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of serotonin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipase C-activating serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in presynaptic modulation of chemical synaptic transmission EXP
Inferred from Experiment
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of presynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic vesicle exocytosis EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to cocaine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to mineralocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of G protein-coupled serotonin receptor complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in calyx of Held EXP
Inferred from Experiment
more info
PubMed 
is_active_in calyx of Held IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in serotonergic synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
5-hydroxytryptamine receptor 1B
Names
5-HT-1B
5-HT1B serotonin receptor
5-hydroxytryptamine (serotonin ) receptor 1B
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
serotonin (5-hydroxytryptamine (5HT)) receptor type 1B
serotonin receptor 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022225.3NP_071561.1  5-hydroxytryptamine receptor 1B

    See identical proteins and their annotated locations for NP_071561.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    P28564
    UniProtKB/TrEMBL
    A6I1P1
    Conserved Domains (1) summary
    cd15333
    Location:42376
    7tmA_5-HT1B_1D; serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    91395405..91414815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264941.1XP_063121011.1  5-hydroxytryptamine receptor 1B isoform X1

    UniProtKB/Swiss-Prot
    P28564
    UniProtKB/TrEMBL
    A6I1P1
    Related
    ENSRNOP00000017411.1, ENSRNOT00000017411.5

RNA

  1. XR_356450.5 RNA Sequence