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Plcb4 phospholipase C, beta 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25031, updated on 2-Nov-2024

Summary

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Official Symbol
Plcb4provided by RGD
Official Full Name
phospholipase C, beta 4provided by RGD
Primary source
RGD:3345
See related
EnsemblRapid:ENSRNOG00000033119 AllianceGenome:RGD:3345
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Beta4aa; RATBETA4AA
Summary
Enables mitogen-activated protein kinase binding activity. Involved in negative regulation of potassium ion transport. Predicted to be located in dendrite; nucleus; and plasma membrane. Predicted to be active in several cellular components, including glutamatergic synapse; parallel fiber to Purkinje cell synapse; and postsynaptic density. Orthologous to human PLCB4 (phospholipase C beta 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 141.5), Heart (RPKM 133.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plcb4 in Genome Data Viewer
Location:
3q36
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (143405721..143775129)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (122952965..123322522)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (128601163..128971720)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene mRNA turnover protein 4 homolog Neighboring gene uncharacterized LOC120101678 Neighboring gene uncharacterized LOC134486450 Neighboring gene U6 spliceosomal RNA Neighboring gene lysosomal-associated membrane protein family, member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning of cDNA encoding rat phospholipase C-beta 4, a new member of the phospholipase C. Kim MJ, et al. Biochem Biophys Res Commun, 1993 Jul 30. PMID 7688223
  2. Purification, molecular cloning, and sequencing of phospholipase C-beta 4. Lee CW, et al. J Biol Chem, 1993 Oct 5. PMID 8407970
  3. A cytosolic, galphaq- and betagamma-insensitive splice variant of phospholipase C-beta4. Kim MJ, et al. J Biol Chem, 1998 Feb 6. PMID 9452490
  4. A unique isoform of phospholipase Cbeta4 highly expressed in the cerebellum and eye. Adamski FM, et al. Biochim Biophys Acta, 1999 Jan 18. PMID 9931434
  5. Expression of phospholipase C-beta4 in rat circumvallate taste buds. Toyono T, et al. Chem Senses, 2005 Jan. PMID 15738151

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study demonistrated that Plcb4 distribuate in rat cerebellum.
    Title: Differential distribution of phospholipase C beta isoforms and diaglycerol kinase-beta in rodents cerebella corroborates the division of unipolar brush cells into two major subtypes.
  2. functional roles of DGK in the pituitary intermediate lobe
    Title: Signaling cascade of diacylglycerol kinase β in the pituitary intermediate lobe: dopamine D2 receptor/phospholipase Cβ4/diacylglycerol kinase β/protein kinase Cα.
  3. Presence of PLCbeta(4) in the heart and in HL-1 cardiomyocytes showing a different species-dependent pattern of expression of the PLCbeta((1-4)) transcripts.
    Title: Phospholipase Cbeta4 isozyme is expressed in human, rat, and murine heart left ventricles and in HL-1 cardiomyocytes.
  4. analysis of phospholipase C-beta4 expression in rat circumvallate taste buds
    Title: Expression of phospholipase C-beta4 in rat circumvallate taste buds.
  5. Stimulation of 5-HT(2) receptors in prefrontal pyramidal neurons inhibits Ca(v)1.2 L type Ca(2+) currents via a PLCbeta/IP3/calcineurin signaling cascade.
    Title: Stimulation of 5-HT(2) receptors in prefrontal pyramidal neurons inhibits Ca(v)1.2 L type Ca(2+) currents via a PLCbeta/IP3/calcineurin signaling cascade.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of potassium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating endothelin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipase C-activating endothelin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phototransduction NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in parallel fiber to Purkinje cell synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in smooth endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Names
PLC-beta-4
phosphoinositide phospholipase C
phosphoinositide phospholipase C-beta-4
NP_077329.2
XP_006235145.1
XP_006235147.1
XP_006235150.1
XP_006235156.1
XP_038960245.1
XP_038960247.1
XP_038960248.1
XP_038960249.1
XP_038960250.1
XP_038960251.1
XP_038960252.1
XP_038960253.1
XP_038960256.1
XP_063139199.1
XP_063139200.1
XP_063139201.1
XP_063139202.1
XP_063139203.1
XP_063139204.1
XP_063139205.1
XP_063139206.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431415.1 → NP_001418344.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HQJ1

  2. NM_001431416.1 → NP_001418345.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    D4A8C5

  3. NM_001431417.1 → NP_001418346.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    D4A8C5

  4. NM_001431418.1 → NP_001418347.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    D4A8C5

  5. NM_001431419.1 → NP_001418348.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform d

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HQJ4

  6. NM_024353.3 → NP_077329.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    O88356, Q9QW07, Q9Z0G6
    UniProtKB/TrEMBL
    F1LNK2
    Conserved Domains (6) summary
    PTZ00121
    Location:840 → 1171
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:703 → 819
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 669
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:915 → 956
    DUF1154; Protein of unknown function (DUF1154)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    143405721..143775129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283129.1 → XP_063139199.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    UniProtKB/TrEMBL
    D4A8C5

  2. XM_063283132.1 → XP_063139202.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    UniProtKB/TrEMBL
    D4A8C5

  3. XM_063283131.1 → XP_063139201.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    UniProtKB/TrEMBL
    D4A8C5

  4. XM_006235085.5 → XP_006235147.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    See identical proteins and their annotated locations for XP_006235147.1

    UniProtKB/TrEMBL
    A0A8I5Y961, D4A8C5
    Conserved Domains (6) summary
    PTZ00121
    Location:859 → 1206
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)

  5. XM_039104325.2 → XP_038960253.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y961, D4A8C5
    Conserved Domains (6) summary
    PTZ00121
    Location:859 → 1206
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)

  6. XM_063283134.1 → XP_063139204.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

    UniProtKB/TrEMBL
    A6HQJ1
    Related
    ENSRNOP00000087693.2, ENSRNOT00000097572.2

  7. XM_039104323.2 → XP_038960251.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y961, D4A8C5
    Conserved Domains (6) summary
    PTZ00121
    Location:859 → 1206
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)

  8. XM_039104321.2 → XP_038960249.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    Conserved Domains (6) summary
    PTZ00121
    Location:859 → 1206
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)

  9. XM_039104317.2 → XP_038960245.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    Conserved Domains (6) summary
    PTZ00121
    Location:859 → 1206
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)

  10. XM_006235083.5 → XP_006235145.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    Related
    ENSRNOP00000045972.3, ENSRNOT00000045393.6
    Conserved Domains (6) summary
    PTZ00121
    Location:859 → 1206
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)

  11. XM_063283136.1 → XP_063139206.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3

  12. XM_063283135.1 → XP_063139205.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

    Related
    ENSRNOP00000076875.2, ENSRNOT00000105709.2

  13. XM_006235094.5 → XP_006235156.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X4

    Related
    ENSRNOP00000048553.4, ENSRNOT00000042853.7
    Conserved Domains (7) summary
    cd00275
    Location:702 → 818
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 668
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02228
    Location:218 → 807
    PLN02228; Phosphoinositide phospholipase C
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:914 → 954
    DUF1154; Protein of unknown function (DUF1154)
    pfam09279
    Location:221 → 312
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam12474
    Location:1048 → 1160
    PKK; Polo kinase kinase

  14. XM_039104322.2 → XP_038960250.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y961, D4A8C5
    Conserved Domains (6) summary
    PTZ00121
    Location:859 → 1206
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)

  15. XM_039104320.2 → XP_038960248.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y961, D4A8C5
    Conserved Domains (6) summary
    PTZ00121
    Location:859 → 1206
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)

  16. XM_039104324.2 → XP_038960252.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y961, D4A8C5
    Conserved Domains (6) summary
    PTZ00121
    Location:859 → 1206
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)

  17. XM_006235088.5 → XP_006235150.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    See identical proteins and their annotated locations for XP_006235150.1

    UniProtKB/TrEMBL
    A0A8I5Y961, D4A8C5
    Conserved Domains (6) summary
    PTZ00121
    Location:859 → 1206
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)

  18. XM_063283133.1 → XP_063139203.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2

    UniProtKB/TrEMBL
    A6HQJ1

  19. XM_039104319.2 → XP_038960247.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y961, D4A8C5
    Conserved Domains (6) summary
    PTZ00121
    Location:859 → 1206
    PTZ00121; MAEBL; Provisional
    cd00275
    Location:714 → 830
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:312 → 680
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 143
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16211
    Location:148 → 300
    EFh_PI-PLCbeta4; EF-hand motif found in phosphoinositide phospholipase C beta 4 (PI-PLC-beta4)
    pfam06631
    Location:926 → 967
    DUF1154; Protein of unknown function (DUF1154)

  20. XM_063283130.1 → XP_063139200.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1

    UniProtKB/TrEMBL
    D4A8C5

  21. XM_039104328.2 → XP_038960256.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5

    Conserved Domains (4) summary
    PTZ00121
    Location:591 → 938
    PTZ00121; MAEBL; Provisional
    cd08591
    Location:44 → 412
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02228
    Location:16 → 551
    PLN02228; Phosphoinositide phospholipase C
    pfam06631
    Location:658 → 699
    DUF1154; Protein of unknown function (DUF1154)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QW07.2 GenPept UniProtKB/Swiss-Prot:Q9QW07

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