Tat tyrosine aminotransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tatprovided by RGD
Official Full Name: tyrosine aminotransferaseprovided by RGD
Primary source: RGD:3820
See related: EnsemblRapid:ENSRNOG00000016348 AllianceGenome:RGD:3820
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables L-tyrosine-2-oxoglutarate transaminase activity and amino acid binding activity. Involved in several processes, including response to dexamethasone; response to mercury ion; and response to oxidative stress. Human ortholog(s) of this gene implicated in tyrosinemia and tyrosinemia type II. Orthologous to human TAT (tyrosine aminotransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 1364.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (54856604..54867168)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (37947153..37957717)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (41675639..41686195, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tat activity in skeletal muscle and liver was determined 24h after the last psychological stress and immobilization stress.
Title: Illuminating the interrelated immune and endocrine adaptations after multiple exposures to short immobilization stress by in vivo blocking of IL-6.
The functionality of Arg315 and Arg417 in rat TAT was investigated for comparison with the conserved Arg292 and Arg386 in aspartate and bacterial aromatic aminotransferases
Title: Involvement of conserved asparagine and arginine residues from the N-terminal region in the catalytic mechanism of rat liver and Trypanosoma cruzi tyrosine aminotransferases.

Submit: New GeneRIF Correction

General gene information

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Markers

GDB:210937 (e-PCR)
- UniSTS:156160

RH94607 (e-PCR)
- UniSTS:119855

D19Mgh2 (e-PCR)
- UniSTS:119345

D19Wox4 (e-PCR)
- UniSTS:118092

Tat (e-PCR), detects polymorphism
- UniSTS:144546

D19Arb5 (e-PCR)
- UniSTS:240549

D19Wox5 (e-PCR)
- UniSTS:119229

D19Wox6 (e-PCR)
- UniSTS:119231

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-tyrosine-2-oxoglutarate transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-tyrosine-2-oxoglutarate transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-tyrosine-2-oxoglutarate transaminase activity	ISO Inferred from Sequence Orthology more info
enables L-tyrosine-2-oxoglutarate transaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables amino acid binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 2-oxoglutarate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in L-phenylalanine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-phenylalanine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in amino acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glutamate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glutamate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to dexamethasone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to mercury ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in tyrosine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tyrosine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in tyrosine catabolic process	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tyrosine aminotransferase

Names: L-tyrosine:2-oxoglutarate aminotransferase

NP_036800.1

EC 2.6.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012668.2 → NP_036800.1 tyrosine aminotransferase

See identical proteins and their annotated locations for NP_036800.1

Status: PROVISIONAL

Source sequence(s)

BC089813

UniProtKB/Swiss-Prot

P04694, Q5EBB6

UniProtKB/TrEMBL

A6IZ42, Q9QWS4

Related

ENSRNOP00000022721.2, ENSRNOT00000022721.6

Conserved Domains (3) summary

cd00609
Location:74 → 436

AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...

TIGR01264
Location:41 → 442

tyr_amTase_E; tyrosine aminotransferase, eukaryotic

pfam07706
Location:1 → 40

TAT_ubiq; Aminotransferase ubiquitination site