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Ptpn7 protein tyrosine phosphatase, non-receptor type 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246781, updated on 2-Nov-2024

Summary

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Official Symbol
Ptpn7provided by RGD
Official Full Name
protein tyrosine phosphatase, non-receptor type 7provided by RGD
Primary source
RGD:708516
See related
EnsemblRapid:ENSRNOG00000005807 AllianceGenome:RGD:708516
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Heptp; Lcptp
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in cytoplasmic side of plasma membrane; cytosol; and mitotic spindle. Orthologous to human PTPN7 (protein tyrosine phosphatase non-receptor type 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 147.3), Spleen (RPKM 97.2) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ptpn7 in Genome Data Viewer
Location:
13q13
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (49122679..49136096)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (46570904..46584048)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (51958023..51971431)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene leucine-rich repeat-containing G protein-coupled receptor 6 Neighboring gene protein tyrosine phosphatase, receptor type, V Neighboring gene uncharacterized LOC120096252 Neighboring gene ADP-ribosylation factor like GTPase 8A Neighboring gene G protein-coupled receptor 37-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hematopoietic protein tyrosine phosphatase suppresses extracellular stimulus-regulated kinase activation. Gronda M, et al. Mol Cell Biol, 2001 Oct. PMID 11564869, Free PMC Article
  2. Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells induces tyrosine phosphorylation of the cytosolic protein-tyrosine phosphatase HePTP. Swieter M, et al. J Biol Chem, 1995 Sep 15. PMID 7545170
  3. Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: dynamics and subcellular location. Nika K, et al. Biochem J, 2004 Mar 1. PMID 14613483, Free PMC Article
  4. Subcellular localization of intracellular protein tyrosine phosphatases in T cells. Gjörloff-Wingren A, et al. Eur J Immunol, 2000 Aug. PMID 10940933
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 7
Names
hematopoietic protein-tyrosine phosphatase
protein-tyrosine phosphatase LC-PTP
NP_663716.1
XP_006249882.1
XP_006249883.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145683.1 → NP_663716.1  tyrosine-protein phosphatase non-receptor type 7

    See identical proteins and their annotated locations for NP_663716.1

    Status: PROVISIONAL

    Source sequence(s)
    U28356
    UniProtKB/Swiss-Prot
    P49445
    UniProtKB/TrEMBL
    A6ICD8, A6ICE0
    Related
    ENSRNOP00000084393.2, ENSRNOT00000114746.2
    Conserved Domains (2) summary
    smart00194
    Location:96 → 347
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:122 → 347
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    49122679..49136096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249821.5 → XP_006249883.1  tyrosine-protein phosphatase non-receptor type 7 isoform X2

    See identical proteins and their annotated locations for XP_006249883.1

    UniProtKB/Swiss-Prot
    P49445
    UniProtKB/TrEMBL
    A6ICD8, A6ICE0
    Related
    ENSRNOP00000103780.1, ENSRNOT00000155289.1
    Conserved Domains (2) summary
    smart00194
    Location:96 → 347
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:122 → 347
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. XM_006249820.5 → XP_006249882.1  tyrosine-protein phosphatase non-receptor type 7 isoform X1

    Conserved Domains (2) summary
    smart00194
    Location:142 → 393
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:168 → 393
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49445.1 GenPept UniProtKB/Swiss-Prot:P49445

Gene LinkOut

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