Tnfsf10 TNF superfamily member 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnfsf10provided by RGD
Official Full Name: TNF superfamily member 10provided by RGD
Primary source: RGD:628734
See related: EnsemblRapid:ENSRNOG00000086118 AllianceGenome:RGD:628734
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Trail; Tnlg6a
Summary: Predicted to enable several functions, including TRAIL binding activity; signaling receptor binding activity; and zinc ion binding activity. Involved in male gonad development; positive regulation of apoptotic process; and response to insulin. Predicted to be located in membrane. Predicted to be active in extracellular space. Biomarker of osteoarthritis and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in arteriosclerosis and small cell carcinoma. Orthologous to human TNFSF10 (TNF superfamily member 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 448.5), Adrenal (RPKM 377.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (112136550..112155903)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (110199835..110227239)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (113008008..113026899)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRAIL inhibition by soluble death receptor 5 protects against acute myocardial infarction in rats.
Title: TRAIL inhibition by soluble death receptor 5 protects against acute myocardial infarction in rats.
TRAIL induces proliferation in rodent pancreatic beta cells via AKT activation.
Title: TRAIL induces proliferation in rodent pancreatic beta cells via AKT activation.
results provide a novel apoptosis-independent, immune regulatory role for TRAIL in suppressing inflammatory arthritis and shed light on the development of effective new therapies for autoimmune inflammatory diseases.
Title: An apoptosis-independent role of TRAIL in suppressing joint inflammation and inhibiting T-cell activation in inflammatory arthritis.
High Trail expression is associated with hypoxic-ischemic brain damage.
Title: Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain damage rat model via suppression of TRAIL signaling pathway.
BAG3 promoted the proliferation and migration of primary rat vascular smooth muscle cells (VSMCs) in a time-dependent manner. BAG3 significantly increased the expression of TRAIL while had no effects on its receptors. TRAIL knockdown or blocking by neutralizing antibody inhibited the proliferation of VSMCs induced by BAG3.
Title: BAG3 promotes the phenotypic transformation of primary rat vascular smooth muscle cells via TRAIL.
our research present that TRAIL affects functional activities of macrophages during ischemia/reperfusion injury
Title: TRAIL facilitates cytokine expression and macrophage migration during hypoxia/reoxygenation via ER stress-dependent NF-κB pathway.
Data suggest that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) may be considered as therapeutic solution to combat insulin-induced vascular pathologies.
Title: Insulin promotes vascular smooth muscle cell proliferation and apoptosis via differential regulation of tumor necrosis factor-related apoptosis-inducing ligand.
Smad2 enhances TRAIL-induced apoptosis in activated hepatic stellate cells, which facilitates the resolution of hepatic fibrosis
Title: Smad2 increases the apoptosis of activated human hepatic stellate cells induced by TRAIL.
Neuroprotection elicited by ischemic preconditioning occurs through both upregulation of TRAIL decoy receptors and downregulation of TRAIL.
Title: Ischemic tolerance modulates TRAIL expression and its receptors and generates a neuroprotected phenotype.
These results suggest that TRAIL inhibits VEGF-induced angiogenesis by increasing caspase-8 activity and subsequently decreasing non-apoptotic signaling functions of procaspase-8, without inducing caspase-3 activation and endothelial cell cytotoxicity.
Title: TRAIL negatively regulates VEGF-induced angiogenesis via caspase-8-mediated enzymatic and non-enzymatic functions.

Submit: New GeneRIF Correction See all GeneRIFs (18)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables TRAIL binding	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info
enables tumor necrosis factor receptor superfamily binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in TRAIL-activated apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in TRAIL-activated apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor necrosis factor ligand superfamily member 10

Names: tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor ligand 6a; tumor necrosis factor superfamily member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145681.2 → NP_663714.2 tumor necrosis factor ligand superfamily member 10

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A0U5J7B5, A6IHG6

Conserved Domains (1) summary

pfam00229
Location:158 → 290

TNF; TNF(tumor Necrosis Factor) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

112136550..112155903

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281308.1 → XP_063137378.1 tumor necrosis factor ligand superfamily member 10 isoform X2
XM_017590632.3 → XP_017446121.1 tumor necrosis factor ligand superfamily member 10 isoform X1

UniProtKB/TrEMBL

A0A0U5J7B5

Related

ENSRNOP00000108553.1, ENSRNOT00000173891.1