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CG46385 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 246653, updated on 10-May-2024

Summary

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Official Symbol
CG46385provided by FlyBase
Primary source
FLYBASE:FBgn0286778
Locus tag
Dmel_CG46385
See related
AllianceGenome:FB:FBgn0286778
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.176; BEST:LD33067; CG1383; CG1557; CG30497; CG30947; CG45093; Dmel\CG46385; EP(2)2618; NEST:bs36c04
Old locus tag
Dmel_CG30497; Dmel_CG45093
Summary
Predicted to enable RNA adenylyltransferase activity. Predicted to be involved in mRNA stabilization. Located in cytosol and nucleoplasm. Is expressed in several structures, including embryonic epidermis; embryonic/larval garland cell; embryonic/larval salivary gland; extended germ band embryo; and ventral ectoderm. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; osteoarthritis; and osteogenesis imperfecta type 18. Orthologous to several human genes including TENT5A (terminal nucleotidyltransferase 5A); TENT5B (terminal nucleotidyltransferase 5B); and TENT5C (terminal nucleotidyltransferase 5C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See CG46385 in Genome Data Viewer
Location:
43E13-43E16; 2-57 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7737019..7782637, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3624524..3670142, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Gdap2 Neighboring gene antisense RNA:CR45108 Neighboring gene mir-4980 stem loop Neighboring gene cinnabar Neighboring gene Calcineurin B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular spectrum of spontaneous de novo mutations in male and female germline cells of Drosophila melanogaster. Watanabe Y, et al. Genetics, 2009 Mar. PMID 19114461, Free PMC Article
  2. A screen for genes that function in leg disc regeneration in Drosophila melanogaster. McClure KD, et al. Mech Dev, 2008 Jan-Feb. PMID 18036784, Free PMC Article
  3. Genome-wide analysis reveals a major role in cell fate maintenance and an unexpected role in endoreduplication for the Drosophila FoxA gene Fork head. Maruyama R, et al. PLoS One, 2011. PMID 21698206, Free PMC Article
  4. Genome-wide identification of neuronal activity-regulated genes in Drosophila. Chen X, et al. Elife, 2016 Dec 9. PMID 27936378, Free PMC Article
  5. The early developmental gene Semaphorin 5c contributes to olfactory behavior in adult Drosophila. Rollmann SM, et al. Genetics, 2007 Jun. PMID 17435226, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c7779880-7779465 mobile_element_type = transposon:HMS-Beagle{}3102

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in nucleoplasm HDA PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG46385-PA
CG46385-PB
CG46385-PC
CG46385-PD
CG46385-PE
CG46385-PF
NP_001260791.1
NP_001356959.1
NP_001356960.1
NP_610321.2
NP_724600.1
NP_724601.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7737019..7782637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273862.1 → NP_001260791.1  uncharacterized protein Dmel_CG46385, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260791.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z745
    Conserved Domains (1) summary
    pfam07984
    Location:52 → 379
    NTP_transf_7; Nucleotidyltransferase

  2. NM_001370032.1 → NP_001356960.1  uncharacterized protein Dmel_CG46385, isoform F [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4P7V9T9
    Conserved Domains (1) summary
    pfam07984
    Location:83 → 410
    NTP_transf_7; Nucleotidyltransferase

  3. NM_165555.3 → NP_724600.1  uncharacterized protein Dmel_CG46385, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724600.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXN9, Q9V4R7
    Related
    FBpp0423178
    Conserved Domains (1) summary
    pfam07984
    Location:83 → 410
    NTP_transf_7; Nucleotidyltransferase

  4. NM_001370031.1 → NP_001356959.1  uncharacterized protein Dmel_CG46385, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4P7VA97
    Conserved Domains (1) summary
    pfam07984
    Location:400 → 727
    NTP_transf_7; Nucleotidyltransferase

  5. NM_136477.4 → NP_610321.2  uncharacterized protein Dmel_CG46385, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610321.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z743, Q6AWD9
    Related
    FBpp0423177
    Conserved Domains (1) summary
    pfam07984
    Location:400 → 727
    NTP_transf_7; Nucleotidyltransferase

  6. NM_165556.3 → NP_724601.1  uncharacterized protein Dmel_CG46385, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724601.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z745
    Related
    FBpp0423180
    Conserved Domains (1) summary
    pfam07984
    Location:52 → 379
    NTP_transf_7; Nucleotidyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A4P7V9T9 A0A4P7V9T9
A0A4P7VA97 A0A4P7VA97
A1Z743 A1Z743
A1Z745 A1Z745
Q8SXN9 Q8SXN9

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