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NT5E-2 Ecto-5'-nucleotidase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 246458, updated on 22-Aug-2024

Summary

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Official Symbol
NT5E-2provided by FlyBase
Official Full Name
Ecto-5'-nucleotidase 2provided by FlyBase
Primary source
FLYBASE:FBgn0050104
Locus tag
Dmel_CG30104
See related
AllianceGenome:FB:FBgn0050104
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG30104; CG4837; Dmel\CG30104; FBgn0050104; NT5E2
Summary
Enables 5'-nucleotidase activity. Involved in dephosphorylation. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hereditary arterial and articular multiple calcification syndrome. Orthologous to human NT5E (5'-nucleotidase ecto). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
54B17-54B17; 2-82 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17485002..17493169)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13372507..13380674)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene insensible Neighboring gene uncharacterized protein Neighboring gene veil Neighboring gene uncharacterized protein Neighboring gene narrow

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional characterization of ecto-5'-nucleotidases and apyrases in Drosophila melanogaster. Fenckova M, et al. Insect Biochem Mol Biol, 2011 Dec. PMID 21996016
  2. Delineating Purinergic Signaling in Drosophila. Volonté C, et al. Int J Mol Sci, 2022 Dec 2. PMID 36499534, Free PMC Article
  3. Epithelial cells release adenosine to promote local TNF production in response to polarity disruption. Poernbacher I, et al. Nat Commun, 2018 Nov 7. PMID 30405122, Free PMC Article
  4. Drosophila activating transcription factor-2 is involved in stress response via activation by p38, but not c-Jun NH(2)-terminal kinase. Sano Y, et al. Mol Biol Cell, 2005 Jun. PMID 15788564, Free PMC Article
  5. Functional Diversity and Evolution of the Drosophila Sperm Proteome. Garlovsky MD, et al. Mol Cell Proteomics, 2022 Oct. PMID 35985624, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

mobile_element

  • Loc: 17485978-17490671 mobile_element_type = transposon:F{}842

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in AMP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleotide catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ecto-5'-nucleotidase 2
Names
CG30104-PA
CG30104-PB
NT5E-2-PA
NT5E-2-PB
NP_611218.1
NP_725681.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17485002..17493169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137374.3 → NP_611218.1  Ecto-5'-nucleotidase 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611218.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZY4
    Related
    FBpp0086084
    Conserved Domains (3) summary
    TIGR01530
    Location:35 → 520
    nadN; NAD pyrophosphatase/5'-nucleotidase NadN
    cd07409
    Location:33 → 320
    MPP_CD73_N; CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain
    pfam02872
    Location:348 → 519
    5_nucleotid_C; 5'-nucleotidase, C-terminal domain

  2. NM_166232.2 → NP_725681.1  Ecto-5'-nucleotidase 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725681.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZY4
    Related
    FBpp0086083
    Conserved Domains (3) summary
    TIGR01530
    Location:35 → 520
    nadN; NAD pyrophosphatase/5'-nucleotidase NadN
    cd07409
    Location:33 → 320
    MPP_CD73_N; CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain
    pfam02872
    Location:348 → 519
    5_nucleotid_C; 5'-nucleotidase, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SZY4 Q8SZY4

Gene LinkOut

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