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Tmem18 Transmembrane protein 18 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 246418, updated on 5-May-2024

Summary

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Official Symbol
Tmem18provided by FlyBase
Official Full Name
Transmembrane protein 18provided by FlyBase
Primary source
FLYBASE:FBgn0050051
Locus tag
Dmel_CG30051
See related
AllianceGenome:FB:FBgn0050051
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-AE003822.1; CG30051; Dmel\CG30051
Summary
Involved in response to starvation. Predicted to be active in nuclear membrane. Used to study abdominal obesity-metabolic syndrome 1; obesity; and type 2 diabetes mellitus. Orthologous to human TMEM18 (transmembrane protein 18). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
49A6-49A6; 2-67 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12436120..12436990)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8323625..8324495)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Deoxyribose-phosphate aldolase Neighboring gene Nucleoporin 54kD Neighboring gene uncharacterized protein Neighboring gene Deubiquitinating apoptotic inhibitor Neighboring gene Dystrobrevin Neighboring gene uncharacterized protein Neighboring gene Lachesin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Channel nuclear pore protein 54 directs sexual differentiation and neuronal wiring of female reproductive behaviors in Drosophila. Nallasivan MP, et al. BMC Biol, 2021 Oct 20. PMID 34666772, Free PMC Article
  2. The Drosophila ortholog of TMEM18 regulates insulin and glucagon-like signaling. Wiemerslage L, et al. J Endocrinol, 2016 Jun. PMID 27029472
  3. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Lu Y, et al. Nat Commun, 2016 Feb 1. PMID 26833246, Free PMC Article
  4. What model organisms and interactomics can reveal about the genetics of human obesity. Williams MJ, et al. Cell Mol Life Sci, 2012 Nov. PMID 22618246
  5. From fat fruit fly to human obesity. Smith WW, et al. Physiol Behav, 2014 Sep. PMID 24508822, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
transmembrane protein 18
Names
CG30051-PC
Tmem18-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12436120..12436990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165902.4 → NP_725169.3  transmembrane protein 18 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725169.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z903, Q4V5Q0
    Conserved Domains (1) summary
    pfam14770
    Location:15 → 133
    TMEM18; Transmembrane protein 18
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z903 A1Z903

Gene LinkOut

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