Cep350 centrosomal protein 350 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cep350provided by RGD
Official Full Name: centrosomal protein 350provided by RGD
Primary source: RGD:621162
See related: EnsemblRapid:ENSRNOG00000003882 AllianceGenome:RGD:621162
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cap350
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in microtubule anchoring. Predicted to act upstream of or within non-motile cilium assembly and protein localization to centrosome. Predicted to be active in centriole and centrosome. Orthologous to human CEP350 (centrosomal protein 350). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 141.1), Kidney (RPKM 137.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q21-q22

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (70573597..70714673, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (68023327..68164478, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (73499715..73637707, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables microtubule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in microtubule anchoring	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to centrosome	ISO Inferred from Sequence Orthology more info
involved_in protein localization to centrosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in centriole	ISO Inferred from Sequence Orthology more info
located_in centriole	ISO Inferred from Sequence Orthology more info
is_active_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: centrosome-associated protein 350

Names: centrosomal protein 350kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427193.1 → NP_001414122.1 centrosome-associated protein 350

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

Related

ENSRNOP00000103622.1, ENSRNOT00000121812.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

70573597..70714673 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091366.2 → XP_038947294.1 centrosome-associated protein 350 isoform X2

UniProtKB/TrEMBL

F1LPD3

Related

ENSRNOP00000005195.10, ENSRNOT00000005195.10

Conserved Domains (4) summary

COG5022
Location:2089 → 2440

COG5022; Myosin heavy chain [General function prediction only]

PRK12704
Location:1675 → 1777

PRK12704; phosphodiesterase; Provisional

PTZ00108
Location:1884 → 2147

PTZ00108; DNA topoisomerase 2-like protein; Provisional

pfam01302
Location:2524 → 2588

CAP_GLY; CAP-Gly domain
XM_039091367.2 → XP_038947295.1 centrosome-associated protein 350 isoform X3

UniProtKB/TrEMBL

A0A1W2Q628, F1LPD3

Related

ENSRNOP00000076113.2, ENSRNOT00000093655.3

Conserved Domains (2) summary

PTZ00121
Location:1683 → 2289

PTZ00121; MAEBL; Provisional

pfam01302
Location:2484 → 2548

CAP_GLY; CAP-Gly domain
XM_039091365.2 → XP_038947293.1 centrosome-associated protein 350 isoform X1

UniProtKB/TrEMBL

D3ZCA4, F1LPD3

Conserved Domains (4) summary

COG5022
Location:2090 → 2441

COG5022; Myosin heavy chain [General function prediction only]

PRK12704
Location:1676 → 1778

PRK12704; phosphodiesterase; Provisional

PTZ00108
Location:1885 → 2148

PTZ00108; DNA topoisomerase 2-like protein; Provisional

pfam01302
Location:2525 → 2589

CAP_GLY; CAP-Gly domain