Gtf3a general transcription factor III A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gtf3aprovided by RGD
Official Full Name: general transcription factor III Aprovided by RGD
Primary source: RGD:619746
See related: EnsemblRapid:ENSRNOG00000050016 AllianceGenome:RGD:619746
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]
Expression: Biased expression in Thymus (RPKM 133.4), Kidney (RPKM 125.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (13250643..13258587, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (8136746..8144690, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (9856841..9864791, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127547 (e-PCR)
- UniSTS:210857

BF390712 (e-PCR)
- UniSTS:249538

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 5S rRNA binding	IEA Inferred from Electronic Annotation more info
enables 5S rRNA binding	ISO Inferred from Sequence Orthology more info
enables 5S rRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase III general transcription initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ribosomal large subunit biogenesis	IEA Inferred from Electronic Annotation more info
involved_in ribosomal large subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal large subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription by RNA polymerase III	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor IIIA

Names: TFIIIA; factor A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113570.1 → NP_001107042.1 transcription factor IIIA

See identical proteins and their annotated locations for NP_001107042.1

Status: REVIEWED

Source sequence(s)

AF391798, CB578423, CB616240, CK842762

UniProtKB/Swiss-Prot

Q8VHT8

UniProtKB/TrEMBL

M0R833

Related

ENSRNOP00000065623.4, ENSRNOT00000073026.4

Conserved Domains (4) summary

COG5048
Location:62 → 185

COG5048; FOG: Zn-finger [General function prediction only]

COG5189
Location:243 → 295

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:43 → 62

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:216 → 237

zf-C2H2; Zinc finger, C2H2 type