S100a4 S100 calcium-binding protein A4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: S100a4provided by RGD
Official Full Name: S100 calcium-binding protein A4provided by RGD
Primary source: RGD:3245
See related: EnsemblRapid:ENSRNOG00000011821 AllianceGenome:RGD:3245
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 42A; 18A2; CAPL; MTS1; P9ka; PEL98; RNP9KA
Summary: Enables actin binding activity; calcium ion binding activity; and calcium-dependent protein binding activity. Predicted to be involved in positive regulation of I-kappaB kinase/NF-kappaB signaling. Located in neuron projection. Orthologous to human S100A4 (S100 calcium binding protein A4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 1115.6), Spleen (RPKM 384.3) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (178388529..178390838)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (176090951..176093258)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (189997278..189999587)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

S100A4 modulates cell proliferation, apoptosis and fibrosis in the hyperplastic prostate.
Title: S100A4 modulates cell proliferation, apoptosis and fibrosis in the hyperplastic prostate.
Upregulation of hypothalamic TRPV4 via S100a4/AMPKalpha signaling pathway promotes the development of diet-induced obesity.
Title: Upregulation of hypothalamic TRPV4 via S100a4/AMPKα signaling pathway promotes the development of diet-induced obesity.
These data suggest that the S100-ErbB axis may be an important mechanism regulating neuronal survival and plasticity.
Title: The S100A4 Protein Signals through the ErbB4 Receptor to Promote Neuronal Survival.
Data indicate that microRNA miR-124 targets S100 calcium-binding protein A4 (S100A4) 3' UTR and regulates vascular smooth muscle cell proliferation.
Title: The microRNA miR-124 inhibits vascular smooth muscle cell proliferation by targeting S100 calcium-binding protein A4 (S100A4).
S100A4 is upregulated in the experimental rat periodontitis.
Title: S100A4 upregulation suppresses tissue ossification and enhances matrix degradation in experimental periodontitis models.
Results show S100A4 expression increasing during fibrotic stage and declining during resolution suggesting it as a good marker for liver fibrogenesis.
Title: Involvement of fibroblast-specific protein 1 (S100A4) and matrix metalloproteinase-13 (MMP-13) in CCl4-induced reversible liver fibrosis.
found a significant increase in the expression of S100A4 in vitreous samples of rats with diabetic retinopathy
Title: S100A4 is upregulated in proliferative diabetic retinopathy and correlates with markers of angiogenesis and fibrogenesis.
TG2 regulates S100A4-mediated mammary tumor cell migration.
Title: The role of TG2 in regulating S100A4-mediated mammary tumour cell migration.
S100A4 modulates p53 function in fibroblasts and thereby mediates myocardial interstitial fibrosis through two distinct mechanisms; cell proliferation and collagen expression.
Title: Metastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts.
The concentration gradient of S100A4 induces direction guidance for neurons and astrocytes.
Title: Tunneling-nanotube direction determination in neurons and astrocytes.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132651 (e-PCR)
- UniSTS:215934

D2Wox23 (e-PCR)
- UniSTS:240037

RH94503 (e-PCR)
- UniSTS:119751

d2arb37 (e-PCR)
- UniSTS:121583

D2Mit13 (e-PCR), detects polymorphism
- UniSTS:227320

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RAGE receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables RAGE receptor binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	TAS Traceable Author Statement more info	PubMed
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	TAS Traceable Author Statement more info	PubMed
enables transition metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein S100-A4

Names: P9K; Protein 9 Ka homologous to calcium-binding protein; calvasculin; metastasin; nerve growth factor-induced protein 42A; placental calcium-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012618.2 → NP_036750.1 protein S100-A4

See identical proteins and their annotated locations for NP_036750.1

Status: PROVISIONAL

Source sequence(s)

J03628

UniProtKB/Swiss-Prot

P05942

UniProtKB/TrEMBL

A6J6P7

Related

ENSRNOP00000015958.1, ENSRNOT00000015958.6

Conserved Domains (1) summary

cd00213
Location:4 → 90

S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

178388529..178390838

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006232592.5 → XP_006232654.1 protein S100-A4 isoform X1

See identical proteins and their annotated locations for XP_006232654.1

UniProtKB/Swiss-Prot

P05942

UniProtKB/TrEMBL

A6J6P7

Conserved Domains (1) summary

cd00213
Location:4 → 90

S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...