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Mcfd2 multiple coagulation factor deficiency 2, ER cargo receptor complex subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 246117, updated on 28-Oct-2024

Summary

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Official Symbol
Mcfd2provided by RGD
Official Full Name
multiple coagulation factor deficiency 2, ER cargo receptor complex subunitprovided by RGD
Primary source
RGD:628690
See related
EnsemblRapid:ENSRNOG00000015059 AllianceGenome:RGD:628690
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sdnsf
Summary
Predicted to enable calcium ion binding activity. Acts upstream of or within carboxylic acid metabolic process. Located in extracellular region. Biomarker of transient cerebral ischemia. Orthologous to human MCFD2 (multiple coagulation factor deficiency 2, ER cargo receptor complex subunit). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Liver (RPKM 1098.5), Adrenal (RPKM 401.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mcfd2 in Genome Data Viewer
Location:
6q12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (13028036..13039388)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (7274469..7285841)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (10887303..10899221, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 7A Neighboring gene uncharacterized LOC120103465 Neighboring gene uncharacterized LOC134479306 Neighboring gene uncharacterized LOC134479307 Neighboring gene uncharacterized LOC134479308

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression change of stem cell-derived neural stem/progenitor cell supporting factor gene in injured spinal cord of rats. Feng Y, et al. Neurosci Bull, 2007 May. PMID 17612595, Free PMC Article
  2. Mutations in the MCFD2 gene are predominant among patients with hereditary combined FV and FVIII deficiency (F5F8D) in India. Jayandharan G, et al. Haemophilia, 2007 Jul. PMID 17610559
  3. Stem cell-derived neural stem/progenitor cell supporting factor is an autocrine/paracrine survival factor for adult neural stem/progenitor cells. Toda H, et al. J Biol Chem, 2003 Sep 12. PMID 12832409
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SDNSF is expressed in the gray matter of spinal cord. The expression of SDNSF mRNA in the spinal cord varies with injured time. (2) The nestin-positive cells proliferate accompanied with spinal cord injury repair, but do not secrete SDNSF.
    Title: Expression change of stem cell-derived neural stem/progenitor cell supporting factor gene in injured spinal cord of rats.
  2. role as an autocrine/paracrine factor in maintaining stem cell potential and lifelong neurogenesis in adult central nervous system
    Title: Stem cell-derived neural stem/progenitor cell supporting factor is an autocrine/paracrine survival factor for adult neural stem/progenitor cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carboxylic acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
multiple coagulation factor deficiency protein 2 homolog
Names
neural stem cell-derived neuronal survival protein
stem cell derived neuronal survival protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139253.2 → NP_640346.2  multiple coagulation factor deficiency protein 2 homolog precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q8K5B3
    UniProtKB/TrEMBL
    A0A0G2JWG5, Q6GQY2
    Related
    ENSRNOP00000069872.1, ENSRNOT00000089104.3
    Conserved Domains (1) summary
    pfam13499
    Location:76 → 142
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    13028036..13039388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239711.5 → XP_006239773.1  multiple coagulation factor deficiency protein 2 homolog isoform X1

    See identical proteins and their annotated locations for XP_006239773.1

    UniProtKB/Swiss-Prot
    Q8K5B3
    UniProtKB/TrEMBL
    A0A0G2JWG5, Q6GQY2
    Conserved Domains (1) summary
    pfam13499
    Location:76 → 142
    EF-hand_7; EF-hand domain pair
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K5B3.1 GenPept UniProtKB/Swiss-Prot:Q8K5B3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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