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ptk2bb protein tyrosine kinase 2 beta, b [ Danio rerio (zebrafish) ]

Gene ID: 245950, updated on 2-Nov-2024

Summary

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Official Symbol
ptk2bbprovided by ZNC
Official Full Name
protein tyrosine kinase 2 beta, bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020507-1
See related
Ensembl:ENSDARG00000039577 AllianceGenome:ZFIN:ZDB-GENE-020507-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ptk2b; ptk2bl; im:6900512
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in epidermal growth factor receptor signaling pathway; positive regulation of cell migration; and regulation of cell adhesion. Predicted to act upstream of or within protein phosphorylation and signal complex assembly. Predicted to be located in anchoring junction; cell projection; and cytoskeleton. Predicted to be active in dendritic spine; focal adhesion; and plasma membrane. Human ortholog(s) of this gene implicated in breast cancer and hypertension. Orthologous to human PTK2B (protein tyrosine kinase 2 beta). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See ptk2bb in Genome Data Viewer
Location:
chromosome: 20
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (19827379..19864185, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (19927796..19959348, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:ch211-142k18.1 Neighboring gene cholinergic receptor, nicotinic, alpha 2b (neuronal) Neighboring gene uncharacterized LOC137488730 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 5a Neighboring gene uncharacterized LOC137488638

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal. Mao K, et al. Front Pharmacol, 2022. PMID 35177988, Free PMC Article
  2. Top2a promotes the development of social behavior via PRC2 and H3K27me3. Geng Y, et al. Sci Adv, 2022 Nov 25. PMID 36417527, Free PMC Article
  3. Evolution and genomic organization of muscle microRNAs in fish genomes. Nachtigall PG, et al. BMC Evol Biol, 2014 Sep 25. PMID 25253178, Free PMC Article
  4. Conservation and early expression of zebrafish tyrosine kinases support the utility of zebrafish as a model for tyrosine kinase biology. Challa AK, et al. Zebrafish, 2013 Sep. PMID 23234507, Free PMC Article
  5. Unilateral dampening of Bmp activity by nodal generates cardiac left-right asymmetry. Veerkamp J, et al. Dev Cell, 2013 Mar 25. PMID 23499359

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in developmental process IEA
Inferred from Electronic Annotation
more info
  
involved_in epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cellular component organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal complex assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein tyrosine kinase 2 beta, b
NP_001410482.1
NP_997735.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001423553.1 → NP_001410482.1  protein tyrosine kinase 2 beta, b

    Status: VALIDATED

    Source sequence(s)
    BX510657
    UniProtKB/TrEMBL
    A0A0R4IZK2, A0A8M1PF87, Q7T2P8
    Related
    ENSDARP00000057818.6, ENSDART00000057819.8

  2. NM_212570.1 → NP_997735.1  protein tyrosine kinase 2 beta, b

    See identical proteins and their annotated locations for NP_997735.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ490510
    UniProtKB/TrEMBL
    A0A0R4IZK2, A0A8M1PF87, Q7T2P8
    Related
    ENSDARP00000141667.2, ENSDART00000161579.2
    Conserved Domains (6) summary
    cd05056
    Location:410 → 678
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:38 → 261
    B41; Band 4.1 homologues
    cd13190
    Location:257 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:149 → 249
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:860 → 989
    Focal_AT; Focal adhesion targeting region
    pfam07714
    Location:417 → 670
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    19827379..19864185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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