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Pwwp3b PWWP domain containing 3B [ Mus musculus (house mouse) ]

Gene ID: 245631, updated on 2-Nov-2024

Summary

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Official Symbol
Pwwp3bprovided by MGI
Official Full Name
PWWP domain containing 3Bprovided by MGI
Primary source
MGI:MGI:2445062
See related
Ensembl:ENSMUSG00000042515 AllianceGenome:MGI:2445062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mum1l1; 9430086K21Rik
Summary
Is expressed in heart; lateral ventricle choroid plexus; metencephalon part of 4th ventricle choroid plexus; tongue muscle; and vertebral axis musculature. Orthologous to human PWWP3B (PWWP domain containing 3B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in limb E14.5 (RPKM 4.6), placenta adult (RPKM 3.8) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Pwwp3b in Genome Data Viewer
Location:
X F1; X 61.29 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (138110726..138139084)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (139209977..139238335)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 pseudogene Neighboring gene RIKEN cDNA 4933428M09 gene Neighboring gene pluripotency associated transcript 21 Neighboring gene STARR-seq mESC enhancer starr_47991 Neighboring gene tumor rejection antigen P1A Neighboring gene STARR-seq mESC enhancer starr_47993 Neighboring gene transcription elongation factor B (SIII), polypeptide 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Endocardiogenesis in embryoid bodies: novel markers identified by gene expression profiling. Narumiya H, et al. Biochem Biophys Res Commun, 2007 Jun 15. PMID 17462595
  2. Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP. Cakir Z, et al. Mol Cell Proteomics, 2023 May. PMID 37019383, Free PMC Article
  3. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  

General protein information

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Preferred Names
PWWP domain-containing DNA repair factor 3B
Names
MUM1-like protein 1
PWWP domain-containing protein MUM1L1
melanoma associated antigen (mutated) 1-like 1
mutated melanoma-associated antigen 1-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164630.1 → NP_001158102.1  PWWP domain-containing DNA repair factor 3B

    See identical proteins and their annotated locations for NP_001158102.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, and 5 encode the same protein
    Source sequence(s)
    AL732419, BC068178, BY713797
    Consensus CDS
    CCDS30432.2
    UniProtKB/Swiss-Prot
    B1AW67, Q0VBL8, Q4VA55, Q7TSI2, Q8BS63
    UniProtKB/TrEMBL
    B2RPZ1
    Related
    ENSMUSP00000108666.2, ENSMUST00000113043.8
    Conserved Domains (1) summary
    cd06080
    Location:375 → 454
    MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

  2. NM_001164631.1 → NP_001158103.1  PWWP domain-containing DNA repair factor 3B

    See identical proteins and their annotated locations for NP_001158103.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AL732419, BC068178, CN695260
    Consensus CDS
    CCDS30432.2
    UniProtKB/Swiss-Prot
    B1AW67, Q0VBL8, Q4VA55, Q7TSI2, Q8BS63
    UniProtKB/TrEMBL
    B2RPZ1
    Related
    ENSMUSP00000108665.3, ENSMUST00000113042.3
    Conserved Domains (1) summary
    cd06080
    Location:375 → 454
    MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

  3. NM_001164632.1 → NP_001158104.1  PWWP domain-containing DNA repair factor 3B

    See identical proteins and their annotated locations for NP_001158104.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AL732419, BC068178, BY124815, CD351791
    Consensus CDS
    CCDS30432.2
    UniProtKB/Swiss-Prot
    B1AW67, Q0VBL8, Q4VA55, Q7TSI2, Q8BS63
    UniProtKB/TrEMBL
    B2RPZ1
    Related
    ENSMUSP00000108664.3, ENSMUST00000113041.9
    Conserved Domains (1) summary
    cd06080
    Location:375 → 454
    MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

  4. NM_001164633.1 → NP_001158105.1  PWWP domain-containing DNA repair factor 3B

    See identical proteins and their annotated locations for NP_001158105.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AL732419
    Consensus CDS
    CCDS30432.2
    UniProtKB/Swiss-Prot
    B1AW67, Q0VBL8, Q4VA55, Q7TSI2, Q8BS63
    UniProtKB/TrEMBL
    B2RPZ1
    Conserved Domains (1) summary
    cd06080
    Location:375 → 454
    MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

  5. NM_175541.3 → NP_780750.2  PWWP domain-containing DNA repair factor 3B

    See identical proteins and their annotated locations for NP_780750.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AL732419, BC068178, BY729100
    Consensus CDS
    CCDS30432.2
    UniProtKB/Swiss-Prot
    B1AW67, Q0VBL8, Q4VA55, Q7TSI2, Q8BS63
    UniProtKB/TrEMBL
    B2RPZ1
    Related
    ENSMUSP00000108668.3, ENSMUST00000113045.9
    Conserved Domains (1) summary
    cd06080
    Location:375 → 454
    MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    138110726..138139084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528544.2 → XP_006528607.1  PWWP domain-containing DNA repair factor 3B isoform X1

    See identical proteins and their annotated locations for XP_006528607.1

    UniProtKB/Swiss-Prot
    B1AW67, Q0VBL8, Q4VA55, Q7TSI2, Q8BS63
    UniProtKB/TrEMBL
    B2RPZ1
    Conserved Domains (1) summary
    cd06080
    Location:375 → 454
    MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

  2. XM_006528541.1 → XP_006528604.1  PWWP domain-containing DNA repair factor 3B isoform X1

    See identical proteins and their annotated locations for XP_006528604.1

    UniProtKB/Swiss-Prot
    B1AW67, Q0VBL8, Q4VA55, Q7TSI2, Q8BS63
    UniProtKB/TrEMBL
    B2RPZ1
    Conserved Domains (1) summary
    cd06080
    Location:375 → 454
    MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

  3. XM_006528543.1 → XP_006528606.1  PWWP domain-containing DNA repair factor 3B isoform X1

    See identical proteins and their annotated locations for XP_006528606.1

    UniProtKB/Swiss-Prot
    B1AW67, Q0VBL8, Q4VA55, Q7TSI2, Q8BS63
    UniProtKB/TrEMBL
    B2RPZ1
    Conserved Domains (1) summary
    cd06080
    Location:375 → 454
    MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

  4. XM_017318499.2 → XP_017173988.1  PWWP domain-containing DNA repair factor 3B isoform X1

    UniProtKB/Swiss-Prot
    B1AW67, Q0VBL8, Q4VA55, Q7TSI2, Q8BS63
    UniProtKB/TrEMBL
    B2RPZ1
    Conserved Domains (1) summary
    cd06080
    Location:375 → 454
    MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

  5. XM_030251345.1 → XP_030107205.1  PWWP domain-containing DNA repair factor 3B isoform X1

    UniProtKB/Swiss-Prot
    B1AW67, Q0VBL8, Q4VA55, Q7TSI2, Q8BS63
    UniProtKB/TrEMBL
    B2RPZ1
    Conserved Domains (1) summary
    cd06080
    Location:375 → 454
    MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4VA55.2 GenPept UniProtKB/Swiss-Prot:Q4VA55

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