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Gask1a golgi associated kinase 1A [ Mus musculus (house mouse) ]

Gene ID: 245050, updated on 2-Nov-2024

Summary

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Official Symbol
Gask1aprovided by MGI
Official Full Name
golgi associated kinase 1Aprovided by MGI
Primary source
MGI:MGI:3041196
See related
Ensembl:ENSMUSG00000038233 AllianceGenome:MGI:3041196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam198a; C730027P07Rik
Summary
Located in Golgi apparatus; endoplasmic reticulum; and extracellular region. Is expressed in naris; orbito-sphenoid; otic capsule; temporal bone petrous part; and turbinate bone primordium. Orthologous to human GASK1A (golgi associated kinase 1A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in ovary adult (RPKM 2.9), limb E14.5 (RPKM 2.9) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Gask1a in Genome Data Viewer
Location:
9 F4; 9 72.76 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (121780057..121817379)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (121950988..121988313)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25540 Neighboring gene cytochrome P450, family 8, subfamily b, polypeptide 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:121836139-121836440 Neighboring gene STARR-positive B cell enhancer mm9_chr9:121837482-121837783 Neighboring gene RIKEN cDNA 1700048O20 gene Neighboring gene STARR-seq mESC enhancer starr_25541 Neighboring gene protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:121902140-121902405 Neighboring gene predicted gene, 39463 Neighboring gene predicted gene, 39465 Neighboring gene predicted gene, 39464

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fam198a, a member of secreted kinase, secrets through caveolae biogenesis pathway. Wei Z, et al. Acta Biochim Biophys Sin (Shanghai), 2018 Oct 1. PMID 30188967
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Clone Names

  • MGC130602

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in caveola IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Golgi-associated kinase 1A
Names
family with sequence similarity 198, member A
protein FAM198A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199927.2 → NP_001186856.1  Golgi-associated kinase 1A isoform 2 precursor

    See identical proteins and their annotated locations for NP_001186856.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences, compared to variant 1. These differences cause translation initiation at an upstream AUG and result in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a longer N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC164092
    UniProtKB/Swiss-Prot
    Q3UY90
    Related
    ENSMUSP00000150724.3, ENSMUST00000214536.3
    Conserved Domains (1) summary
    pfam15051
    Location:236 → 493
    FAM198; FAM198 protein

  2. NM_001408673.1 → NP_001395602.1  Golgi-associated kinase 1A isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164092

  3. NM_001408674.1 → NP_001395603.1  Golgi-associated kinase 1A isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164092
    Related
    ENSMUSP00000151175.2, ENSMUST00000213773.2

  4. NM_001408675.1 → NP_001395604.1  Golgi-associated kinase 1A isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164092
    UniProtKB/Swiss-Prot
    Q3TYS0, Q3UTV8, Q3UY90, Q8C7H6
    Related
    ENSMUSP00000149755.3, ENSMUST00000215990.3

  5. NM_177743.6 → NP_808411.1  Golgi-associated kinase 1A isoform 1 precursor

    See identical proteins and their annotated locations for NP_808411.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC164092
    Consensus CDS
    CCDS52969.1
    UniProtKB/Swiss-Prot
    Q3UY90
    Related
    ENSMUSP00000040221.8, ENSMUST00000043011.9
    Conserved Domains (1) summary
    pfam15051
    Location:220 → 544
    FAM198; FAM198 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    121780057..121817379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512132.3 → XP_006512195.1  Golgi-associated kinase 1A isoform X1

    Conserved Domains (1) summary
    pfam15051
    Location:236 → 493
    FAM198; FAM198 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UY90.1 GenPept UniProtKB/Swiss-Prot:Q3UY90

Gene LinkOut

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