Inha inhibin subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Inhaprovided by RGD
Official Full Name: inhibin subunit alphaprovided by RGD
Primary source: RGD:2912
See related: EnsemblRapid:ENSRNOG00000020097 AllianceGenome:RGD:2912
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables inhibin binding activity. Involved in male gonad development; negative regulation of follicle-stimulating hormone secretion; and ovarian follicle development. Located in several cellular components, including neuronal cell body; photoreceptor inner segment; and photoreceptor outer segment. Part of inhibin A complex and inhibin B complex. Biomarker of Leydig cell tumor. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human INHA (inhibin subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 277.3), Heart (RPKM 175.3) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (84443109..84446010)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (76994465..76997366)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (82700482..82703383)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhba overexpression in rat ovary in vivo may change reproductive endocrine function.
Title: Changes in the reproductive endocrine function in rat following intraovary microinjection of inhba overexpression lentivirus vectors.
Both the hormonal milieu of perimenopause and the association of dynamic perimenopausal changes in FSH and inhibin A with decreased bone mineral density have been reproduced in an animal model.
Title: Decreased bone mineral density in rats rendered follicle-deplete by an ovotoxic chemical correlates with changes in follicle-stimulating hormone and inhibin A.
The effect of steroidogenic substrates and follicle stimulating hormone on steroid, inhibin A and B, Pro-alphaC and activin A production was evaluated.
Title: Regulation of inhibin/activin expression in rat early antral follicles.
Betaglycan is an endogenous inhibin coreceptor required for high-sensitivity inhibin antagonism of activin signaling in rat anterior pituitary gonadotropes.
Title: Endogenous betaglycan is essential for high-potency inhibin antagonism in gonadotropes.
findings revealed that each granulosa cell expresses a stable amount of inhibin-alpha subunit mRNA independently of antral formation in immature rat ovaries
Title: New approach to in situ quantification of ovarian gene expression in rat using a laser microdissection technique: relationship between follicle types and regulation of inhibin-alpha and cytochrome P450aromatase genes in the rat ovary.
Within the testis, inhibin A levels fall from 0.330 +/- 0.108 ng/g at d 15 to less than 0.004 ng/g at maturity.
Title: Changes in circulating and testicular levels of inhibin A and B and activin A during postnatal development in the rat.
there are two distinct mechanisms by which C/EBPbeta represses inhibin alpha-subunit gene expression in ovarian granulosa cells.
Title: Repression of the inhibin alpha-subunit gene by the transcription factor CCAAT/enhancer-binding protein-beta.
Data indicate that the inhibin alpha subunit influences a number of the reproductive functions of female mice.
Title: Changes in the reproductive functions of mice due to injection of a plasmid expressing an inhibin alpha-subunit into muscle: a transient transgenic model.
beta-catenin synergizes with steroidogenic factor-1 to activate the alpha-inhibin promoter through formation of a transcriptional complex
Title: Convergence of Wnt signaling and steroidogenic factor-1 (SF-1) on transcription of the rat inhibin alpha gene.
the mechanisms of Inhibin-alpha repression by ICER
Title: Mechanism of repression of the inhibin alpha-subunit gene by inducible 3',5'-cyclic adenosine monophosphate early repressor.

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General gene information

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Markers

REN53413 (e-PCR)
- UniSTS:378213

D9Wox10 (e-PCR)
- UniSTS:118138

Inha (e-PCR), detects polymorphism
- UniSTS:118138

UniSTS:143587 (e-PCR)
- UniSTS:143587

Inha (e-PCR), detects polymorphism
- UniSTS:143587

RH136772 (e-PCR)
- UniSTS:218861

ECD17211 (e-PCR)
- UniSTS:298224

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables inhibin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in hemoglobin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hemoglobin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of follicle-stimulating hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of inhibin A complex	IDA Inferred from Direct Assay more info	PubMed
part_of inhibin A complex	ISO Inferred from Sequence Orthology more info
part_of inhibin B complex	IDA Inferred from Direct Assay more info	PubMed
part_of inhibin-betaglycan-ActRII complex	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inhibin alpha chain

Names: inhibin alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.