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Mtnr1b melatonin receptor 1B [ Mus musculus (house mouse) ]

Gene ID: 244701, updated on 18-Sep-2024

Summary

Official Symbol
Mtnr1bprovided by MGI
Official Full Name
melatonin receptor 1Bprovided by MGI
Primary source
MGI:MGI:2181726
See related
Ensembl:ENSMUSG00000050901 AllianceGenome:MGI:2181726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mt2; Mel1b; Mel-1B-R
Summary
Predicted to enable melatonin receptor activity. Predicted to be involved in several processes, including negative regulation of cGMP-mediated signaling; negative regulation of transport; and regulation of transmission of nerve impulse. Predicted to act upstream of or within circadian rhythm. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; eye; gut; and reproductive system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MTNR1B (melatonin receptor 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Mtnr1b in Genome Data Viewer
Location:
9 A2; 9 5.15 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (15773910..15785852, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (15862614..15874556, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 2 pseudogene Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 4 Neighboring gene STARR-seq mESC enhancer starr_23387 Neighboring gene STARR-seq mESC enhancer starr_23388 Neighboring gene STARR-seq mESC enhancer starr_23389 Neighboring gene FAT atypical cadherin 3 Neighboring gene STARR-seq mESC enhancer starr_23390 Neighboring gene STARR-seq mESC enhancer starr_23391 Neighboring gene STARR-seq mESC enhancer starr_23392 Neighboring gene STARR-seq mESC enhancer starr_23393 Neighboring gene predicted gene, 53499 Neighboring gene STARR-seq mESC enhancer starr_23398 Neighboring gene STARR-seq mESC enhancer starr_23400 Neighboring gene STARR-seq mESC enhancer starr_23401 Neighboring gene nucleophosmin 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC129286, MGC129287

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables melatonin receptor activity ISA
Inferred from Sequence Alignment
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within circadian rhythm TAS
Traceable Author Statement
more info
PubMed 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transmission of nerve impulse ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transmission of nerve impulse ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuronal action potential ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISA
Inferred from Sequence Alignment
more info
PubMed 

General protein information

Preferred Names
melatonin receptor type 1B
Names
MT2 melatonin receptor
Mel-1b melatonin receptor
mel1b receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145712.2NP_663758.2  melatonin receptor type 1B

    See identical proteins and their annotated locations for NP_663758.2

    Status: VALIDATED

    Source sequence(s)
    AB377276
    Consensus CDS
    CCDS22841.1
    UniProtKB/Swiss-Prot
    Q80T38, Q8CIQ6, Q8K3K0
    UniProtKB/TrEMBL
    Q3SXF8
    Related
    ENSMUSP00000053086.6, ENSMUST00000057920.7
    Conserved Domains (2) summary
    pfam00001
    Location:57308
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:55192
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    15773910..15785852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)