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Elmod2 ELMO/CED-12 domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 244548, updated on 2-Nov-2024

Summary

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Official Symbol
Elmod2provided by MGI
Official Full Name
ELMO/CED-12 domain containing 2provided by MGI
Primary source
MGI:MGI:2445165
See related
Ensembl:ENSMUSG00000035151 AllianceGenome:MGI:2445165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9830169G11Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in regulation of defense response to virus. Is expressed in several structures, including adrenal gland; genitourinary system; gut gland; nervous system; and stomach. Orthologous to human ELMOD2 (ELMO domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 5.0), CNS E18 (RPKM 5.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Elmod2 in Genome Data Viewer
Location:
8 C2; 8 39.72 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84039261..84059115, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83312632..83332490, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 9 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22078 Neighboring gene uncoupling protein 1 (mitochondrial, proton carrier) Neighboring gene STARR-seq mESC enhancer starr_22080 Neighboring gene STARR-positive B cell enhancer ABC_E1762 Neighboring gene predicted gene, 32327 Neighboring gene MGAT4 family, member C Neighboring gene cofilin 1, non-muscle pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The ARF GAP ELMOD2 acts with different GTPases to regulate centrosomal microtubule nucleation and cytokinesis. Turn RE, et al. Mol Biol Cell, 2020 Aug 15. PMID 32614697, Free PMC Article
  2. GTPase-activating protein Elmod2 is essential for meiotic progression in mouse oocytes. Zhou CX, et al. Cell Cycle, 2017 May 3. PMID 28324667, Free PMC Article
  3. Roles for ELMOD2 and Rootletin in ciliogenesis. Turn RE, et al. Mol Biol Cell, 2021 Apr 15. PMID 33596093, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Roles for ELMOD2 and Rootletin in ciliogenesis.
    Title: Roles for ELMOD2 and Rootletin in ciliogenesis.
  2. The ARF GAP ELMOD2 acts with different GTPases to regulate centrosomal microtubule nucleation and cytokinesis.
    Title: The ARF GAP ELMOD2 acts with different GTPases to regulate centrosomal microtubule nucleation and cytokinesis.
  3. Elmod2 is the GTPase-activating protein essential to meiosis progression of mouse oocytes, most likely by regulating mitochondrial dynamics.
    Title: GTPase-activating protein Elmod2 is essential for meiotic progression in mouse oocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in regulation of defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ELMO domain-containing protein 2
Names
ELMO domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170691.1 → NP_001164162.1  ELMO domain-containing protein 2

    See identical proteins and their annotated locations for NP_001164162.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC122890, AK036607
    Consensus CDS
    CCDS22450.1
    UniProtKB/Swiss-Prot
    Q6AXC7, Q8BGF6, Q8BHP5
    Related
    ENSMUSP00000137044.2, ENSMUST00000177594.8
    Conserved Domains (1) summary
    pfam04727
    Location:110 → 268
    ELMO_CED12; ELMO/CED-12 family

  2. NM_178736.5 → NP_848851.3  ELMO domain-containing protein 2

    See identical proteins and their annotated locations for NP_848851.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC122890, AK084950
    Consensus CDS
    CCDS22450.1
    UniProtKB/Swiss-Prot
    Q6AXC7, Q8BGF6, Q8BHP5
    Related
    ENSMUSP00000052287.4, ENSMUST00000053902.4
    Conserved Domains (1) summary
    pfam04727
    Location:110 → 268
    ELMO_CED12; ELMO/CED-12 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    84039261..84059115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154033.1 → XP_036009926.1  ELMO domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6AXC7, Q8BGF6, Q8BHP5
    Conserved Domains (1) summary
    pfam04727
    Location:110 → 268
    ELMO_CED12; ELMO/CED-12 family

  2. XM_006530979.4 → XP_006531042.1  ELMO domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006531042.1

    UniProtKB/Swiss-Prot
    Q6AXC7, Q8BGF6, Q8BHP5
    Conserved Domains (1) summary
    pfam04727
    Location:110 → 268
    ELMO_CED12; ELMO/CED-12 family

RNA

  1. XR_004934824.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGF6.1 GenPept UniProtKB/Swiss-Prot:Q8BGF6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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