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Triml1 tripartite motif family-like 1 [ Mus musculus (house mouse) ]

Gene ID: 244448, updated on 18-Sep-2024

Summary

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Official Symbol
Triml1provided by MGI
Official Full Name
tripartite motif family-like 1provided by MGI
Primary source
MGI:MGI:2687279
See related
Ensembl:ENSMUSG00000031651 AllianceGenome:MGI:2687279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933403D14
Summary
Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; and regulation of viral entry into host cell. Predicted to be active in cytosol and nucleoplasm. Is expressed in early conceptus and testis. Orthologous to human TRIML1 (tripartite motif family like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 5.7) See more
Orthologs
human all
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Genomic context

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See Triml1 in Genome Data Viewer
Location:
8 A4; 8 23.89 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (43582843..43633531, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (43129806..43180494, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21308 Neighboring gene predicted gene, 26181 Neighboring gene tryptophanyl-tRNA synthetase pseudogene Neighboring gene STARR-seq mESC enhancer starr_21309 Neighboring gene STARR-seq mESC enhancer starr_21310 Neighboring gene STARR-seq mESC enhancer starr_21312 Neighboring gene STARR-seq mESC enhancer starr_21313 Neighboring gene STARR-seq mESC enhancer starr_21314 Neighboring gene STARR-seq mESC enhancer starr_21316 Neighboring gene bromodomain adjacent to zinc finger domain, 2A pseudogene Neighboring gene tripartite motif family-like 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_21317 Neighboring gene STARR-seq mESC enhancer starr_21318 Neighboring gene STARR-seq mESC enhancer starr_21319 Neighboring gene STARR-seq mESC enhancer starr_21325 Neighboring gene zinc finger protein 42

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization and potential function of a novel pre-implantation embryo-specific RING finger protein: TRIML1. Tian L, et al. Mol Reprod Dev, 2009 Jul. PMID 19156909
  2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterized TRIML1, which expresses in embryo before implantation; binding partner of TRIML1, Ubiquitin-specific protease 5 (USP5), was identified
    Title: Characterization and potential function of a novel pre-implantation embryo-specific RING finger protein: TRIML1.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase TRIML1
Names
RING-type E3 ubiquitin transferase TRIML1
tripartite motif family-like protein 1
NP_808410.1
XP_006509485.1
XP_011240521.1
XP_011240524.1
XP_017168289.1
XP_017168290.1
XP_017168291.1
XP_017168292.1
XP_017168293.1
XP_017168294.1
XP_017168295.1
XP_017168297.1
XP_017168298.1
XP_017168299.1
XP_030099397.1
XP_030099398.1
XP_030099399.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177742.4 → NP_808410.1  probable E3 ubiquitin-protein ligase TRIML1

    See identical proteins and their annotated locations for NP_808410.1

    Status: VALIDATED

    Source sequence(s)
    AK077092
    Consensus CDS
    CCDS22266.1
    UniProtKB/Swiss-Prot
    Q8BVP1
    UniProtKB/TrEMBL
    B2RUL3
    Related
    ENSMUSP00000050267.4, ENSMUST00000059692.4
    Conserved Domains (2) summary
    pfam15227
    Location:22 → 62
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd13733
    Location:293 → 468
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    43582843..43633531 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312805.2 → XP_017168294.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X8

    Conserved Domains (1) summary
    cd13733
    Location:150 → 325
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

  2. XM_017312810.1 → XP_017168299.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X8

    Conserved Domains (1) summary
    cd13733
    Location:150 → 325
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

  3. XM_017312809.1 → XP_017168298.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X8

    Conserved Domains (1) summary
    cd13733
    Location:150 → 325
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

  4. XM_017312804.1 → XP_017168293.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X8

    Conserved Domains (1) summary
    cd13733
    Location:150 → 325
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

  5. XM_017312806.1 → XP_017168295.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X8

    Conserved Domains (1) summary
    cd13733
    Location:150 → 325
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

  6. XM_017312808.1 → XP_017168297.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X8

    Conserved Domains (1) summary
    cd13733
    Location:150 → 325
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

  7. XM_017312803.1 → XP_017168292.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X7

    UniProtKB/TrEMBL
    B2RUL3
    Conserved Domains (3) summary
    TIGR00599
    Location:20 → 161
    rad18; DNA repair protein rad18
    cd13733
    Location:242 → 417
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cd16590
    Location:19 → 63
    RING-HC_TRIM4_C-IV_like; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM4, TRIM75, tripartite motif family-like protein 1 (TRIML1) and similar proteins

  8. XM_017312801.1 → XP_017168290.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X2

    UniProtKB/TrEMBL
    B2RUL3
    Conserved Domains (3) summary
    TIGR00599
    Location:20 → 161
    rad18; DNA repair protein rad18
    cd13733
    Location:319 → 494
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cd16590
    Location:19 → 63
    RING-HC_TRIM4_C-IV_like; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM4, TRIM75, tripartite motif family-like protein 1 (TRIML1) and similar proteins

  9. XM_011242219.2 → XP_011240521.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X3

    UniProtKB/TrEMBL
    B7ZNZ0
    Conserved Domains (3) summary
    TIGR00599
    Location:20 → 161
    rad18; DNA repair protein rad18
    cd13733
    Location:319 → 494
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cd16590
    Location:19 → 63
    RING-HC_TRIM4_C-IV_like; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM4, TRIM75, tripartite motif family-like protein 1 (TRIML1) and similar proteins

  10. XM_017312800.1 → XP_017168289.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X1

    UniProtKB/TrEMBL
    B7ZNZ0
    Conserved Domains (3) summary
    TIGR00599
    Location:20 → 161
    rad18; DNA repair protein rad18
    cd13733
    Location:320 → 495
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cd16590
    Location:19 → 63
    RING-HC_TRIM4_C-IV_like; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM4, TRIM75, tripartite motif family-like protein 1 (TRIML1) and similar proteins

  11. XM_030243537.1 → XP_030099397.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X6

    UniProtKB/TrEMBL
    B2RUL3
    Conserved Domains (3) summary
    TIGR00599
    Location:20 → 161
    rad18; DNA repair protein rad18
    cd13733
    Location:292 → 467
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cd16590
    Location:19 → 63
    RING-HC_TRIM4_C-IV_like; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM4, TRIM75, tripartite motif family-like protein 1 (TRIML1) and similar proteins

  12. XM_017312802.1 → XP_017168291.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X5

    UniProtKB/TrEMBL
    B7ZNZ0
    Conserved Domains (3) summary
    TIGR00599
    Location:20 → 161
    rad18; DNA repair protein rad18
    cd13733
    Location:293 → 468
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cd16590
    Location:19 → 63
    RING-HC_TRIM4_C-IV_like; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM4, TRIM75, tripartite motif family-like protein 1 (TRIML1) and similar proteins

  13. XM_011242222.2 → XP_011240524.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X10

    Conserved Domains (1) summary
    cd13733
    Location:123 → 298
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

  14. XM_030243539.1 → XP_030099399.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X10

    Conserved Domains (1) summary
    cd13733
    Location:123 → 298
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

  15. XM_030243538.1 → XP_030099398.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X9

    Conserved Domains (1) summary
    cd13733
    Location:124 → 299
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

  16. XM_006509422.4 → XP_006509485.1  probable E3 ubiquitin-protein ligase TRIML1 isoform X4

    UniProtKB/TrEMBL
    B7ZNZ0
    Conserved Domains (3) summary
    TIGR00599
    Location:20 → 161
    rad18; DNA repair protein rad18
    cd13733
    Location:294 → 469
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cd16590
    Location:19 → 63
    RING-HC_TRIM4_C-IV_like; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM4, TRIM75, tripartite motif family-like protein 1 (TRIML1) and similar proteins

RNA

  1. XR_003947277.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BVP1.1 GenPept UniProtKB/Swiss-Prot:Q8BVP1

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